Methods for injecting a contrast medium to generate prolonged uniform vascular enhancement

• US 6,055,985 A
• Filed: 04/09/1999
• Issued: 05/02/2000
• Est. Priority Date: 04/09/1999
• Status: Active Grant

• Current Assignee: Bhb Lc
• Original Assignee: Bhb Lc
• Inventors: Bae, Kyongtae T., Tran, Huy Q.
• Primary Examiner(s): Milano, Michael J.
• Assistant Examiner(s): Nguyen, Dinh X.
• Application Number:
  US09/289,430
• Time in Patent Office: 389 Days
• Field of Search: 128/898, 604/30, 604/246, 604/131, 604/187, 600/431, 378/8, 378/95
• US Class Current: 604/28
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/14546 Front-loading type injectors
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump

Abstract

A contrast medium injector for injecting a patient with contrast medium for a CT scan is programmed to provide an injection protocol that is a representation of an ideally defined exponential curve with an initial injection rate decaying at an exponential rate. This has been found to produce a uniform vascular enhancement for the scanning of a patient'"'"'s blood vessels. The particular exponential decay coefficient which has been found to be optimal is directly proportional to the cardiac output divided by the patient'"'"'s weight and is approximated at 0.01 for a typical human.

Claims

1. A method for substantially maintaining a desired level of vascular enhancement in a patient substantially throughout a desired interval of an injection routine by intravascularly injecting a contrast agent, said method comprising the steps of:

beginning the injection routine desired interval substantially at a preselected initial injection rate, and

controllably decreasing the injection rate during the injection routine.

2. The method of claim 1 wherein the decreasing step comprises ramping the injection rate during at least part of the injection routine desired interval.

3. The method of claim 2 wherein the ramping is performed substantially throughout the entirety of the injection routine desired interval.

4. The method of claim 1 wherein the decreasing step comprises decreasing the injection rate at substantially an exponential rate having a decay coefficient approximating a selected cardiac output per body weight typifying the patient.

5. The method of claim 1 further comprising the steps of determining a volume of contrast agent to be used during the injection routine, determining a desired level of enhancement to be attained, and determining the desired interval during which the desired level of enhancement is to be substantially achieved.

6. The method of claim 5 further comprising the step of adjusting the initial injection rate in proportion to the selected cardiac output typifying said patient.

7. The method of claim 1 further comprising the step of adjusting the initial injection rate in proportion to a selected cardiac output per body weight typifying the patient.

8. The method of claim 1 wherein said injection rate is decreased at rate equal to a substantially linear approximation of an exponential function having as its decay coefficient a value directly proportional to a cardiac output per body weight typifying the patient.

9. A method for substantially maintaining a desired level of vascular enhancement in a patient substantially throughout a desired interval of an injection routine by intravascularly injecting a contrast agent, said method comprising the steps of:

beginning the injection routine desired interval at a preselected initial injection rate, and

substantially continuously reducing the injection rate as the routine continues.

10. The method of claim 9 wherein the step of continuously reducing the injection rate includes the step of reducing it at substantially an exponential rate having a decay coefficient approximating a selected cardiac output per body weight typifying the patient.

11. The method of claim 10 further comprising the steps of determining a volume of contrast agent to be used during the injection routine, determining a desired level of enhancement to be attained, and determining the desired interval during which the desired level of enhancement is to be substantially achieved.

12. The method of claim 11 further comprising the step of adjusting the initial injection rate in proportion to said selected cardiac output.

13. The method of claim 9 wherein said injection rate is reduced at a rate equal to a substantially linear approximation of an exponential function having as its decay coefficient a value directly proportional to a cardiac output per body weight typifying the patient.

14. A method for substantially maintaining a desired level of vascular enhancement in a patient substantially throughout a desired interval of an injection routine by intravascularly injecting a contrast agent, said method comprising the steps of:

beginning the injection routine substantially at a preselected initial injection rate, and

substantially continuously reducing the injection rate at a reduction rate calculated to be substantially dependent on a selected cardiac output per body weight typifying the patient.

15. The method of claim 14 wherein said reduction rate is an exponential function having as its decay coefficient a value directly proportional to cardiac output per body weight typifying the patient.

16. The method of claim 14 wherein said reduction rate is a substantially linear approximation of an exponential function having as its decay coefficient a value directly proportional to a cardiac output per body weight typifying the patient.

17. A method for substantially maintaining a desired level of vascular enhancement in a patient substantially throughout a desired interval of an injection routine by intravascularly injecting a contrast agent, said method comprising the steps of:

implementing a multiphasic injection protocol for injection of said contrast agent.

18. The method of claim 17 further comprising the step of beginning the injection routine substantially at a preselected initial rate.

19. The method of claim 18 wherein said multiphasic injection protocol is an exponential function.

20. The method of claim 19 wherein said exponential function has a decay coefficient of approximately 0.01.