Optical diffraction biosensor
First Claim
Patent Images
1. A biosensor comprising:
- a polymer film coated with metal; and
a patterned receptor layer printed onto the polymer film wherein the receptor layer has a receptive material thereon that specifically binds an analyte;
wherein the receptor layer is printed in a pattern such that when the biosensor binds an analyte, the biosensor diffracts transmitted light or reflected light to form a diffraction pattern visible to an unaided eye.
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Abstract
The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the plastic film upon which the receptor is printed, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
235 Citations
29 Claims
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1. A biosensor comprising:
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a polymer film coated with metal; and a patterned receptor layer printed onto the polymer film wherein the receptor layer has a receptive material thereon that specifically binds an analyte; wherein the receptor layer is printed in a pattern such that when the biosensor binds an analyte, the biosensor diffracts transmitted light or reflected light to form a diffraction pattern visible to an unaided eye. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of making a biosensor comprising applying a receptor layer to a polymer film coated with metal in a pattern such that when an analyte binds to the patterned receptor layer, the patterned receptor layer thereby forms a diffraction image visible to an unaided eye.
Specification