Encoded combinatorial chemical libraries
DC CAFCFirst Claim
1. A bifunctional molecule according to the formula A--B--C, wherein A is a polymer comprising a linear series of chemical units represented by the formula (Xn)a, wherein X is a single chemical unit in polymer A, B is a linker molecule operatively linked to A and C. and identifier oligonucleotide C is represented by the formula (Zn)a, wherein a unit identifier nucleotide sequence Z within oligonucleotide C identifies the chemical unit X at position n;
- and wherein n is a position identifier for both X in polymer A and Z in oligonucleotide C having the value of 1+i where i is an integer from 0 to 10, such that when n is 1, X or Z is located most proximal to the linker, and a is an integer from 4 to 50.
0 Assignments
Litigations
1 Petition
Accused Products
Abstract
The present invention describes an encoded combinatorial chemical library comprised of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence that defines the structure of the chemical polymer. Also described are the bifunctional molecules of the library, and methods of using the library to identify chemical structures within the library that bind to biologically active molecules in preselected binding interactions.
-
Citations
17 Claims
-
1. A bifunctional molecule according to the formula A--B--C, wherein A is a polymer comprising a linear series of chemical units represented by the formula (Xn)a, wherein X is a single chemical unit in polymer A, B is a linker molecule operatively linked to A and C. and identifier oligonucleotide C is represented by the formula (Zn)a, wherein a unit identifier nucleotide sequence Z within oligonucleotide C identifies the chemical unit X at position n;
- and wherein n is a position identifier for both X in polymer A and Z in oligonucleotide C having the value of 1+i where i is an integer from 0 to 10, such that when n is 1, X or Z is located most proximal to the linker, and a is an integer from 4 to 50.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
Specification