Catheter apparatus for positioning a wire

• US 6,061,588 A
• Filed: 09/29/1998
• Issued: 05/09/2000
• Est. Priority Date: 09/29/1998
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Baker, Ross, Thornton, Richard T.
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US09/162,733
• Time in Patent Office: 588 Days
• Field of Search: 600/1, 600/373, 600/374, 600/381, 600/424, 600/434, 600/435, 600/547, 600/585
• US Class Current: 600/424
• CPC Class Codes: A61N 2005/1008 Apparatus for temporary insertion of sources, e.g. afterloaders
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body

Abstract

A method and apparatus for positioning a radioactive portion of a wire at one or more positions within the lumen of a guide catheter, such as for intravascular radiotherapy, are disclosed. The method and the apparatus provide for better positioning the radioactive portion in light of bunching of the wire within the lumen during insertion. A computerized controller uses a monitoring device to control an afterloader'"'"'s insertion and withdrawal of the wire into the guide catheter. The guide catheter includes a sensor at its distal end, the sensor being an electrical contact having conductive surfaces exposed within the lumen and outside the guide catheter. The wire is electrically conductive, and is configured to come into contact with the sensor'"'"'s conductive surface within the lumen when the wire is fully inserted into the lumen. The monitoring device includes one lead connected to the wire and a second lead connected to the subject'"'"'s body. The monitoring device is configured to use an alternating current signal to sense a closed circuit extending sequentially through a signal path including the wire, the sensor, and the subject'"'"'s body, when the wire comes into contact with the sensor.

The computer controller directs the afterloader to insert the wire into the lumen until a closed circuit is sensed. The controller then directs the afterloader to controllably withdraw the wire until the circuit is broken, thus removing any bunching from the wire. The wire then can be maintained in position at the end of the lumen to irradiate the subject. The wire also may be withdrawn by prescribed amounts to other positions within the lumen, to treat the subject at these locations.

Claims

1. A method for positioning a wire in a selected portion of a subject'"'"'s body, comprising:

providing a guide catheter having a lumen configured to receive the wire;

providing a sensor configured to detect the presence of a predetermined portion of the wire at a predetermined position within the lumen;

inserting the guide catheter to a selected location in the subject'"'"'s body;

advancing the wire along the lumen;

monitoring the sensor to determine when the predetermined portion of the wire reaches the predetermined position within the lumen; and

terminating the step of advancing the wire when it is determined, in the step of monitoring the sensor, that the predetermined portion of the wire has reached the predetermined position within the lumen.

2. The method defined in claim 1, wherein:

the step of inserting the guide catheter locates the guide catheter in a portion of the subject'"'"'s cardiovascular system; and

the wire is configured to treat the selected portion of the subject'"'"'s body by irradiation.

3. The method defined in claim 1, wherein, in the step of providing a sensor, the sensor is integral with the guide catheter.

4. The method defined in claim 3, wherein:

the sensor comprises an electrical contact having an exposed surface within the lumen;

the wire is configured to be electrically conductive from a proximal portion to its predetermined portion; and

the step of monitoring the sensor comprises monitoring the resistance between the sensor and the proximal portion of the wire to determine when the predetermined portion of the wire and the sensor'"'"'s exposed surface within the lumen come into contact.

5. The method defined in claim 4, wherein:

the predetermined portion of the wire, in the step of providing a wire, is at a distal tip of the wire; and

the sensor, in the step of providing a sensor, is located at a distal end of the guide catheter.

6. The method defined in claim 4, wherein:

the sensor, in the step of providing a sensor, includes an exposed surface on the exterior of the guide catheter that is electrically connected to the sensor'"'"'s exposed surface within the lumen; and

the step of monitoring the resistance between the sensor and the proximal portion of the wire comprises monitoring the resistance between the subject'"'"'s body and the proximal portion of the wire.

7. The method defined in claim 6, wherein the step of monitoring the resistance between the subject'"'"'s body and the proximal portion of the wire comprises applying a varying voltage between the subject'"'"'s body and the proximal portion of the wire to pass an ac signal between the subject'"'"'s body and the proximal portion of the wire.

8. The method defined in claim 4, and further comprising providing a conductor that extends along substantially the entire length of the guide catheter and electrically connects to the sensor'"'"'s exposed surface within the lumen, wherein, in the step of monitoring the resistance, the monitored resistance is measured across the conductor and the proximal portion of the wire.

9. The method defined in claim 1, and further comprising:

further monitoring the sensor to determine when the predetermined portion of the wire departs from the predetermined position within the lumen;

controllably withdrawing the wire from the lumen after the step of advancing the wire; and

terminating the step of controllably withdrawing the wire when it is determined, in the step of further monitoring the sensor, that the predetermined portion of the wire has departed from the predetermined position within the lumen.

10. The method defined in claim 9, and further comprising maintaining the wire in its position, for a prescribed period of time, after the step of terminating the step of controllably withdrawing the wire.

11. The method defined in claim 10, and further comprising:

withdrawing the wire from the lumen by a prescribed amount; and

maintaining the wire in its position, for a prescribed period of time, immediately after the completion of the step of withdrawing the wire from the lumen by a prescribed amount.

12. The method defined in claim 9, and further comprising:

withdrawing the wire from the lumen by prescribed amounts to one or more positions; and

maintaining the wire for prescribed periods of time at the one or more positions.

13. The method defined in claim 1, and further comprising

further monitoring the sensor to determine when the predetermined portion of the wire departs from the predetermined position within the lumen;

controllably withdrawing the wire from the lumen after the step of advancing the wire; and

terminating the step of controllably withdrawing the wire when it is determined, in the step of further monitoring the sensor, that the predetermined portion of the wire has departed from the predetermined position within the lumen;

wherein the sensor comprises an electrical contact having an exposed surface within the lumen;

wherein the wire is configured to be electrically conductive from a proximal portion to its predetermined portion; and

wherein the step of monitoring the sensor comprises monitoring the resistance between the sensor and the proximal portion of the wire to determine when the predetermined portion of the wire and the sensor'"'"'s exposed surface within the lumen come into contact.

14. The method defined in claim 13, and further comprising:

maintaining the wire in its position for a prescribed period of time after the step of terminating the step of controllably withdrawing the wire;

withdrawing the wire from the lumen by a prescribed amount; and

maintaining the wire in its position, for a prescribed period of time, immediately after the completion of the step of withdrawing the wire from the lumen by a prescribed amount;

wherein the sensor, in the step of providing a sensor, includes an exposed surface on the exterior of the guide catheter that is electrically connected to the sensor'"'"'s exposed surface within the lumen; and

wherein the step of monitoring the resistance between the sensor and the proximal portion of the wire further comprises monitoring the resistance between the subject'"'"'s body and the proximal portion of the wire by applying a varying voltage between the subject'"'"'s body and the proximal portion of the wire to pass an ac signal between the subject'"'"'s body and the wire.

15. A method for positioning a wire in a selected portion of a subject'"'"'s body, comprising:

providing a guide catheter having a lumen configured to receive the wire;

providing a sensor configured to detect the presence of a predetermined portion of the wire at a predetermined position within the lumen;

inserting the guide catheter to a selected location in the subject'"'"'s body;

advancing the wire along the lumen;

terminating the step of advancing the wire when the predetermined portion of the wire has reached the predetermined position within the lumen;

monitoring the sensor to determine when the predetermined portion of the wire departs from the predetermined position within the lumen;

controllably withdrawing the wire from the lumen after the step of advancing the wire; and

terminating the step of controllably withdrawing the wire when it is determined, in the step of monitoring the sensor, that the predetermined portion of the wire has departed from the predetermined position within the lumen.

16. The method defined in claim 15, and further comprising maintaining the wire in its position, for a prescribed period of time, after the step of terminating the step of controllably withdrawing the wire.

17. The method defined in claim 16, and further comprising:

withdrawing the wire from the lumen by a prescribed amount; and

maintaining the wire in its position, for a prescribed period of time, immediately after the completion of the step of withdrawing the wire from the lumen by a prescribed amount.

18. The method defined in claim 15, and further comprising:

withdrawing the wire from the lumen by prescribed amounts to one or more positions; and

maintaining the wire for prescribed periods of time at the one or more positions.

19. A catheter apparatus for use within a subject, comprising:

a guide catheter sized to be insertable within a subject, the guide catheter including a lumen extending into the guide catheter;

a wire sized to be insertable into the guide catheter'"'"'s lumen to a predetermined position;

a sensor of the guide catheter configured to detect the presence of a predetermined portion of the wire at a predetermined longitudinal position along the guide catheter; and

a monitoring device configured to monitor the sensor to determine when the predetermined portion of the wire is present at the predetermined position along the guide catheter.

20. The catheter apparatus defined in claim 19, wherein the wire is configured with a radioactive portion proximate its predetermined portion, for irradiating a selected portion of a subject'"'"'s body.

21. The catheter apparatus defined in claim 19, wherein:

the wire is configured to be electrically conductive from its predetermined portion to a portion configured to be connected to the monitoring device;

wherein the sensor is an electrical contact having a surface exposed within the lumen at the predetermined position, to detect the presence of the predetermined portion of the guide catheter; and

wherein the monitoring device is configured to monitor a signal path extending from its connection to the wire to the sensor.

22. The catheter apparatus defined in claim 21, wherein the monitoring device connects to the patent'"'"'s body, and wherein sensor has an exposed surface on the exterior of the guide catheter to extend the signal path through the subject'"'"'s body back to the monitoring device.

23. The catheter apparatus defined in claim 21, wherein the sensor further comprises a conductor that extends along substantially the entire length of the guide catheter and electrically connects the monitoring device to the surface exposed within the lumen.

24. The catheter apparatus defined in claim 19, wherein the sensor is located at a distal end of the guide catheter.

25. A catheter for use in positioning a wire in a selected portion of a subject'"'"'s body, comprising a guide catheter sized to be insertable within a subject, wherein:

the guide catheter has surfaces forming a blind lumen that extends into the guide catheter;

the guide catheter is configured for receiving the wire into the lumen;

the guide catheter'"'"'s surfaces that form the lumen are composed of a material that does not conduct electricity; and

the guide catheter includes an electrical contact having an exposed surface within the lumen at a location within the subject'"'"'s body.

26. The catheter defined in claim 25, wherein the electrical contact includes an exposed surface on the exterior of the lumen that is configured to contact the subject'"'"'s body.

27. The catheter defined in claim 25, wherein the sensor further comprises a conductor that extends along substantially the entire length of the guide catheter and electrically connects the monitoring device to the exposed surface within the lumen.

28. A brachytherapy apparatus for irradiating a selected portion of a subject'"'"'s body comprising:

a guide catheter sized to be insertable within the selected portion of the subject'"'"'s body, the guide catheter including a lumen extending into the guide catheter;

a wire having a radioactive portion, the wire being sized to be insertable into the lumen such that the radioactive portion is proximate the selected portion of the subject'"'"'s body when the guide catheter is inserted within the selected portion of the subject'"'"'s body; and

a sensor of the guide catheter configured to be located proximate the selected portion of the subject'"'"'s body, the sensor being configured to detect the presence of a predetermined portion of the wire at a predetermined longitudinal position along the guide catheter.

29. The brachytherapy apparatus defined in claim 28, wherein the sensor is an electrical contact located at the predetermined longitudinal position along the guide catheter, the sensor being configured to complete an electrical signal path for detecting the presence of the predetermined portion of the wire at the predetermined longitudinal position along the guide catheter when the sensor is in contact with the predetermined portion of the wire.

30. The brachytherapy apparatus defined in claim 29, wherein the sensor includes a conductive surface exposed on the exterior of the guide catheter such that the signal path can pass through the subject'"'"'s body to the monitoring device.

31. The brachytherapy apparatus defined in claim 29, wherein the sensor further comprises a conductor that extends along substantially the entire length of the guide catheter and electrically connects to the surface exposed within the lumen.

32. The brachytherapy apparatus defined in claim 28, wherein the sensor is located at a distal end of the guide catheter.

33. A method for treating a subject, comprising:

providing a treatment catheter configured to treat the subject;

providing a guiding catheter;

providing a sensor configured to detect the presence of a predetermined portion of the treatment catheter at a predetermined position along the guiding catheter;

inserting the guiding catheter to a selected location in the subject'"'"'s body;

advancing the treatment catheter along the guiding catheter;

monitoring the sensor to determine when the predetermined portion of the treatment catheter reaches the predetermined position along the guiding catheter; and

terminating the step of advancing the treatment catheter when it is determined, in the step of monitoring the sensor, that the predetermined portion of the treatment catheter has reached the predetermined position along the guiding catheter.

34. The method defined in claim 33, and further comprising

further monitoring the sensor to determine when the predetermined portion of the treatment catheter departs from the predetermined position along the guiding catheter;

controllably withdrawing the treatment catheter from along the guiding catheter after the step of advancing the treatment catheter; and

terminating the step of controllably withdrawing the treatment catheter when it is determined, in the step of further monitoring the sensor, that the predetermined portion of the treatment catheter has departed from the predetermined position along the guiding catheter.

35. The method defined in claim 34, and further comprising:

withdrawing the treatment catheter from along the guiding catheter by a prescribed amount; and

maintaining the treatment catheter in its position, for a prescribed period of time, immediately after the completion of the step of withdrawing the treatment catheter from along the guiding catheter by a prescribed amount.