EEG d-c voltage shift as a means for detecting the onset of a neurological event

• US 6,061,593 A
• Filed: 04/24/1998
• Issued: 05/09/2000
• Est. Priority Date: 10/27/1997
• Status: Expired due to Term

• Current Assignee: Neuropace Inc.
• Original Assignee: Neuropace Inc.
• Inventors: Fischell, David R., Fischell, Robert E., Upton, Adrian R. M.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US09/065,739
• Time in Patent Office: 746 Days
• Field of Search: 600/378, 600/544
• US Class Current: 600/544
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators
• CPC Class Codes: G16H 20/40 relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture

Abstract

Disclosed herein is a multiple electrode, closed-loop system for the treatment of certain neurological disorders such as epilepsy, migraine headaches and Parkinson'"'"'s disease. Specifically, the present invention combines a multi-electrode array with sophisticated signal processing techniques to achieve reliable detection of the onset of a neurological event (such as an epileptic seizure or migraine headache) typically originating from a focus of limited spatial extent within the brain. It is highly desirable to detect an epileptic seizure at least 5 seconds before the onset of clinical symptoms. Since there is often a d-c shift in the EEG voltage more than 5 seconds before the seizure, disclosed herein is a means for utilizing the d-c shift of the EEG for early detection of the seizure.

Claims

1. A system for the detection of neurological disorders of a human patient, the system comprising:

at least two brain electrodes adapted to be located at a location selected from the group consisting of a portion of a patient'"'"'s scalp and a portion of the patient'"'"'s brain, the electrodes being adapted for the reception of EEG signals;

a control module implanted within the human patient'"'"'s body for transmitting output electrical signals from the control module to the patient'"'"'s brain, responsive to input electrical signals originating in the patient'"'"'s brain, the control module including electronic circuitry for processing the EEG signals;

electrical conducting means for providing electrical connections between the electrodes and the electronic circuitry of the control module, said electronic circuitry of the control module, the electrical conducting means and the at least two electrodes being electrically coupled to provide a means for detecting a neurological event by the processing of at least one EEG signal received from at least one electrode, the processing including the detection of a d-c shift in the received EEG signal, the d-c shift having all of its frequency components below 0.5 Hz; and

external equipment means adapted to be located external to the human patient, for providing communication between the external equipment means and the control module for receiving data transmission from the control module and detecting said neurological disorder responsive to said d-c shift in said EEG signal.

2. The system of claim 1 wherein there are exactly two electrodes.

3. The system of claim 1 wherein the control module includes an outer surface having at least a portion of the outer surface being electrically conducting defining one of the electrodes, and at least one of the other electrodes being an active electrode connected to the control module by the electrical conducting means.

4. The system of claim 1 wherein there are at least three electrodes.

5. The system of claim 4 wherein the control module includes an outer surface, at least a portion of the outer surface being electrically conducting and at least one of the electrodes defining an active electrode connected to the control module by the electrical conducting means.

6. The system of claim 1 wherein there are at least four electrodes.

7. The system of claim 6 wherein the control module includes an outer surface, at least a portion of the outer surface being electrically conducting and constituting one of the electrodes, and at least one of the other electrodes defining an active electrode connected to the control module by the electrical conducting means.

8. The system of claim 1 wherein at least one electrode is positionally located within the brain of the human patient defining a deep electrode.

9. The system of claim 8 wherein the deep electrode is positionally located within the hippocampus region of the brain.

10. The system of claim 8 wherein the deep electrode is positionally located within the thalamus region of the brain.

11. The system of claim 1 wherein at least one electrode defines a brain surface electrode, the brain surface electrode being positionally located under the dura mater of the patient'"'"'s brain.

12. The system of claim 1 wherein at least one electrode is positionally located on an outer surface of the patient'"'"'s scalp defining a scalp electrode.

13. The system of claim 1 wherein at least one electrode is positionally located under the dura mater of the patient'"'"'s brain defining a brain surface electrode.

14. The system of claim 1 wherein at least two electrodes are positionally located under the dura mater of the patient'"'"'s brain defining brain surface electrodes and at least one other electrode is positionally located within the brain of the human patient defining a deep electrode.

15. The system of claim 14 wherein the brain surface electrodes are positioned within 2 centimeters of the center of an epileptic focus of an epileptic patient.

16. The system of claim 1 wherein the control module is positionally located within the patient'"'"'s chest.

17. The system of claim 1 wherein the control module is positionally located under the patient'"'"'s scalp.

18. The system of claim 1 wherein the d-c shift detection processing is selectively programmable.

19. The system of claim 18 wherein the programmability includes the selection of at least one EEG signal to be processed by the electronic circuitry from the brain electrodes.