Dispensing apparatus

• US 6,062,212 A
• Filed: 04/11/1995
• Issued: 05/16/2000
• Est. Priority Date: 11/04/1992
• Status: Expired due to Term

• Current Assignee: Consort Medical PLC (Recipharm AB)
• Original Assignee: Bespak Corporation
• Inventors: Davison, John Robin, Brace, Geoffrey, Barnes, Paul
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): SRIVASTAVA, VIRENDRA KUMAR
• Application Number:
  US08/392,978
• Time in Patent Office: 1,862 Days
• Field of Search: 128/200.14, 128/200.16, 128/200.17, 128/200.18, 128/200.21, 128/200.23, 128/203.12, 128/203.16, 128/205.15, 128/203.15, 239/102.2
• US Class Current: 128/200.16
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: B01F 23/2132 using nozzles
• CPC Class Codes: B01F 35/71 Feed mechanisms with proportioning B01F35/80
• CPC Class Codes: B01F 35/7179 using sprayers, nozzles or jets
• CPC Class Codes: B05B 17/0638 spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
• CPC Class Codes: B05B 17/0646 Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
• CPC Class Codes: B05B 17/0676 Feeding means

Abstract

A dispensing apparatus which defines an outlet through which a metered dose of liquid from a reservoir is dispersed as an atomized spray. A droplet of liquid is metered onto a perforate membrane which is vibrated by way of a piezoelectric transducer such that atomized droplets are dispensed through the holes formed in the membrane. At each actuation of a delivery device, which provides the metered quantity of liquid, the transducer is actuated so as to vibrate the membrane for a period greater than the dispensing period required for the droplet to be dispensed. The apparatus is particularly suitable for dispensing pharmaceutical preparations.

Claims

1. Dispensing apparatus comprising a housing defining a dispensing outlet, a perforate membrane having a front face exposed at the outlet and a rear face contacted in use by liquid to be dispensed, vibrating means connected to the housing and operable to vibrate the membrane to dispense droplets of the liquid through the membrane, liquid supply means connected to the housing and having an outlet valve, and delivery means operable at successive actuations of the delivery means to deliver a respective metered quantity of the liquid from the liquid supply means via the outlet valve into contact with the rear face of the membrane and means for operating the vibrating means for an operating period greater than a dispensing period required for the metered quantity to be dispensed though the membrane whereby in use all of the dispensed liquid is consumed prior to the next successive actuation of the delivery means, such that the liquid is isolated from the ambient air between successive actuations of the delivery means.

2. Dispensing apparatus as claimed in claim 1 wherein the liquid supply means comprises a reservoir containing liquid and the delivery means comprises a metering pump connected to the reservoir, the metering pump comprising a cylinder defining a chamber and a piston reciprocatably mounted in the cylinder to displace a metered volume of liquid from the chamber at each actuating stroke.

3. Dispensing apparatus as claimed in claim 1 wherein the liquid supply means comprises a pressurised dispensing container within which a supply of liquid is maintained under pressure and the delivery means comprises a metering valve constituting the outlet valve and operable to release from the container the metered quantity of liquid.

4. Dispensing apparatus as claimed in claim 1 wherein the housing comprises an annular member connected peripherally to the vibrating means and defining a central aperture overlaid by the membrane.

5. Dispensing apparatus as claimed in claim 4 wherein the annular member comprises an upper surface which is concave so as to be downwardly sloping in a radially inward direction when the apparatus is held in use in a preferred operating orientation.

6. Dispensing apparatus as claimed in claim 5 wherein the upper surface of the annular member is formed of a liquid repellant material.

7. Dispensing apparatus as claimed in claim 5 wherein the annular member comprises a radially innermost surface portion defining the aperture and co-operating with the membrane to define a well for receiving in use a droplet of liquid constituting the metered quantity of liquid to be dispensed.

8. Dispensing apparatus as claimed in claim 1 wherein the housing defines a duct communicating between an air inlet and an outlet port, the dispensing outlet being located in the duct intermediate the air inlet and the outlet port such that the front face of the membrane is exposed to air within the duct.

9. Dispensing apparatus as claimed in claim 8 wherein an air impeller is connected to the housing so as to be operable to create a flow of air through the duct from the air inlet to the outlet port.

10. Dispensing apparatus as claimed in claim 9 wherein the housing defines an eye cup communicating with the duct.

11. Dispensing apparatus as claimed in claim 8 wherein the outlet port comprises an inhalation port for oral or nasal use.

12. Dispensing apparatus as claimed in claim 1 wherein the means for operating the vibrating means comprises a timer connected to the vibrating means and operable to determine the operating period during which the vibrating means is actuated and wherein the operating period is selected to be greater than the dispensing period required for the metered quantity to be dispensed through the membrane.

15. Dispensing apparatus as recited in claim 1, wherein said delivery means delivers a droplet of liquid to said rear face of said perforate membrane and said droplet of liquid constitutes the metered quantity of liquid to be dispensed.

16. Dispensing apparatus as recited in claim 5, wherein said delivery means delivers a droplet of liquid to said rear face of said perforate membrane and said droplet of liquid constitutes the metered quantity of liquid to be dispensed.

13. A method of dispensing liquid as an atomised spray comprising the steps of delivering a metered quantity of liquid from a liquid supply means via an outlet valve into contact with a rear face of a perforate membrane vibrating the membrane such that liquid is dispensed through the membrane as an atomised spray, wherein the membrane is initially free from liquid and the liquid is isolated from the ambient air between successive deliveries of liquid and in that the membrane is vibrated for an operating period grater than a dispensing period required for the metered quantity to be fully dispensed.

17. The method of dispensing liquid as described in claim 13, wherein delivering a metered quantity of liquid to the rear face of said perforate membrane includes delivering a droplet of liquid to said rear face with said droplet constituting the metered quantity of liquid to be dispensed.

14. Dispensing apparatus comprising a housing defining a dispensing outlet, a perforate membrane having a front face exposed at the outlet and a rear face contacted in use by liquid to be dispensed, vibrating means connected to the housing and operable to vibrate the membrane to dispense droplets of the liquid through the membrane, liquid supply means connected to the housing and delivery means operable at successive actuations of the delivery means to deliver a respective metered quantity of the liquid from the liquid supply means into contact with the rear face of the membrane whereby in use a metered quantity of liquid is dispensible as an atomised spray at the outlet by operation of the vibrating means for an operating period greater than a dispensing period required for the metered quantity to be dispensed through the membrane and wherein the liquid supply means comprises a plurality of cells each containing a metered volume of liquid and the delivery means comprises a dispensing station operable to release at each actuation thereof the contents of a respective cell.

18. A dispensing apparatus comprising:

a sealed liquid supply container;

a delivery tube extending from said supply container and being in fluid communication with said supply container at a first end and having an outlet nozzle end at an opposite end;

a liquid drop reception device which includes a liquid drop reception well for receiving a liquid drop delivered by said delivery tube and which liquid drop reception well is at least partly defined by a perforated membrane, and said nozzle outlet and membrane being positioned such that a liquid drop derived from said sealed liquid supply container is positioned between the nozzle outlet and said membrane with the liquid drop attached to the membrane;

a housing structure that is configured so as to preclude environmental contact with the liquid except through perforations formed in said membrane, and the perforations in said membrane being dimensioned so as to create an atomized spray of liquid droplets upon vibration of said membrane.

21. A dispensing apparatus as recited in claim 18, wherein the perforations in said membrane are dimensioned so as to produce a fine mist of liquid droplets suitable for inhalation therapy and said sealed liquid supply container contains a pharmaceutical liquid.

22. A dispensing device as recited in claim 18, wherein said liquid drop reception device includes an annular support member extending about said membrane and having a peripheral section in contact with said housing.

23. A dispensing device as recited in claim 22, wherein said annular support member includes a converging section which has a thinnermost portion secured to said perforated membrane for centering the liquid drop on the membrane.

24. A dispensing device as recited in claim 18, further comprising a piezo electric vibrator for vibrating said perforated membrane with said piezo electric vibrator being supported by said housing.

25. A dispensing apparatus as recited in claim 18, further comprising a valve in line with said delivery tube which releases the one drop when open and seals off the supply container when closed.

26. A dispensing apparatus as recited in claim 18, further comprising means for vibrating said membrane and means for operating said vibrating means for an operating period which exceeds a period of time required for dispensing the drop received on said membrane at a vibration rate of said means for vibrating.

27. A dispensing device as recited in claim 18, wherein said sealed liquid container is flexible so as to be deformable and is sized so as to include a single dose of liquid such that when said liquid container is deformed in use all liquid contained therein is released to said delivery tube so as to be received by said perforated membrane.

28. A dispensing device as recited in claim 27, wherein said delivery tube converges in diameter with a larger inlet end and has an axis of elongation which is positioned so as to extend through said membrane.

29. A dispensing device as recited in claim 18, wherein said delivery tube is arranged vertically within said housing such that the liquid drop drops down into contact with a rear face of said membrane upon release from said delivery tube.

19. Dispensing apparatus comprising a housing defining a dispensing outlet, a perforate membrane having a front face exposed to the outlet and a rear face contacted in use by liquid to be dispensed, vibrating means operable to vibrate the membrane to dispense droplets of the liquid through the membrane, liquid supply means supported by said housing and having an outlet valve, and delivery means operable at successive actuations of the delivery means to deliver a respective metered, single dose quantity of the liquid from a multi-dose supply liquid of the liquid supply means via the outlet valve into contact with the rear face of the membrane and said outlet valve of said liquid supply means and said delivery means being arranged so as to isolate the multi-dose supply of liquid of said liquid supply means from contact with contaminants between successive actuations of the liquid supply means, and said dispensing apparatus further comprising operating means for operating the vibrating means for an operating period greater than a dispensing period required for the metered quantity to be dispensed through the membrane whereby in use all of the dispensed liquid is consumed prior to the next successive actuation of the delivery means, such that the liquid of said liquid supply means is isolated from contaminants and there is avoided any dispensed liquid remaining on said membrane between the end of an operating period and the next successive actuation of the delivery means.

20. A dispensing device as recited in claim 19 wherein the operating period of said operating means is based on a time period set by a timer of said operating means.

30. Dispensing apparatus comprising a housing defining a dispensing outlet, a perforate membrane having a front face exposed to the outlet and a rear face contacted in use by liquid to be dispensed, vibrating means connected to the housing and operable to vibrate the membrane to dispense droplets of the liquid through the membrane, liquid supply means connected to the housing and having an outlet valve, and delivery means operable at successive actuations of the delivery means to deliver a respective metered quantity of the liquid form the liquid supply means via the outlet valve into contact with the rear face of the membrane, and means for operating the vibrating means for an operating period greater than a dispensing period required for the metered quantity to be dispensed through the membrane whereby in use all of the dispensed liquid is consumed prior to the next successive actuation of the delivery means, such that there is avoided any exposure of liquid to ambient air following the dispensing operating period and prior to a next successive actuation of the delivery means.

31. A method of dispensing liquid as an atomized spray comprising the steps of delivering a metered quantity of liquid from a liquid supply means via an outlet valve into contact with a rear face of a perforate membrane with any liquid remaining in said liquid supply means being sealed off by said outlet valve, vibrating the membrane such that liquid is dispensed through the membrane as an atomized spray, and in that the membrane is vibrated for an operating period greater than a dispensing period required for the metered quantity to be fully dispensed such that all of the metered quantity of liquid delivered to the perforate membrane via the outlet valve is consumed to avoid any exposure of liquid to ambient air following the operating period and prior to a next successive delivery of liquid from said liquid supply means to the rear face of the perforate membrane.