Diagnostic method for inflammatory conditions in the intestines

• US 6,063,027 A
• Filed: 05/30/1997
• Issued: 05/16/2000
• Est. Priority Date: 11/30/1994
• Status: Expired due to Fees

• Current Assignee: Aerocrine AB (Circassia Group Plc)
• Original Assignee: Aerocrine AB (Circassia Group Plc)
• Inventors: Weitzberg, Eddie, Lundberg, Jon, Alving, Kjell, Lundberg, Jan M.
• Primary Examiner(s): Willse, David H.
• Assistant Examiner(s): CAMPEN, KELLY SCAGGS
• Application Number:
  US08/849,282
• Time in Patent Office: 1,082 Days
• Field of Search: 128/898, 514/42, 514/492, 514/52, 600/300, 600/301, 600/560, 600/562, 600/593, 436/110, 436/116
• US Class Current: 600/300
• CPC Class Codes: A61B 10/00 Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis vaccination prophylaxis, vaccination therapy A61B17/20; Sex determination; Ovulation-period determination menstruation tables G06C3/00; Throat striking implements
• CPC Class Codes: A61B 2010/0083 for taking gas samples
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath
• CPC Class Codes: Y10T 436/173076 Nitrite or nitrate

Abstract

Method for diagnosis of inflammatory conditions in the intestinal canal of humans, characterized in that NO is measured in the lumen of the intestines. The NO level obtained is then compared with the level obtained for healthy individuals or with the level obtained for the same individual at another occasion. An increased level compared to the normal levels in the intestines of the healthy population is an indication of an inflammatory condition in the intestine.

Claims

1. A method for diagnosing inflammatory conditions in the intestinal canal of a human, comprising the steps of:

obtaining a gas sample from the lumen of the intestines of the human;

measuring the level of nitric oxide in the gas sample;

comparing the measured level with the expected level for a healthy human or with a prior level measured in the human; and

diagnosing the presence or absence of an inflammatory condition using the results of said comparison.

2. The method according to claim 1, wherein the sample is taken from the lumen of an emptied intestine.

3. The method according to any one of claims 1-2, wherein the sample is collected from the lumen of the colon.

4. The method according to any one of claims 1-2, wherein the sample is collected from the lumen of the rectum.

5. The method according to any one of claims 1-2 wherein an increased level of nitric oxide indicates ulcerative colitis.

6. The method according to any one of claims 1-2 wherein an increased level of nitric oxide indicates Crohn'"'"'s disease.