Automated treatment selection method
First Claim
1. A method for predicting a response of a patient to a selected treatment for unipolar depression from at least one pre-treatment clinical symptom, comprising:
- a.) performing at least one measurement of said pre-treatment clinical symptom on said patient and measuring said pre-treatment clinical symptom which is a predictive symptom selected from the group consisting of predictive symptoms so as to derive data for a baseline patient profile;
b.) defining a set of a plurality of predictor variables which define said data for said baseline patient profile, said set of predictor variables comprising said predictive symptoms and a set of treatment options;
c.) deriving a model that represents a relationship between a response of a patient in a study and said set of predictor variables, said relationship derived through using at least one automated non-linear algorithm; and
d.) utilizing said model of step c) to predict the response of said patient to the selected treatment.
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Abstract
A method useful for facilitating choosing a treatment or treatment regime and for predicting the outcome of a treatment for a disorder which is diagnosed and monitored by a physician or other appropriately trained and licensed professional, such as for example, a psychologist, based upon the symptoms experienced by a patient. Unipolar depression is an example of such a disorder, however the model may find use with other disorders and conditions wherein the patient response to treatment is variable. In the preferred embodiment, the method for predicting patient response includes the steps of performing at least one measurement of a symptom on a patient and measuring that symptom so as to derive a baseline patient profile, such as for example, determining the symptom profile with time; defining a set of a plurality of predictor variables which define the data of the baseline patient profile, wherein the set of predictor variables includes predictive symptoms and a set of treatment options; deriving a model that represents the relationship between patient response and the set of predictor variables; and utilizing the model to predict the response of said patient to a treatment. A neural net architecture is utilized to define a non-linear, second order model which is utilized to analyze the patient data and generate the predictive database from entered patient data.
354 Citations
33 Claims
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1. A method for predicting a response of a patient to a selected treatment for unipolar depression from at least one pre-treatment clinical symptom, comprising:
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a.) performing at least one measurement of said pre-treatment clinical symptom on said patient and measuring said pre-treatment clinical symptom which is a predictive symptom selected from the group consisting of predictive symptoms so as to derive data for a baseline patient profile; b.) defining a set of a plurality of predictor variables which define said data for said baseline patient profile, said set of predictor variables comprising said predictive symptoms and a set of treatment options; c.) deriving a model that represents a relationship between a response of a patient in a study and said set of predictor variables, said relationship derived through using at least one automated non-linear algorithm; and d.) utilizing said model of step c) to predict the response of said patient to the selected treatment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of treating depression in a clinical patient comprising the following steps:
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a.) defining a set of predictor variables which define a set of data of a baseline patient profile, said set of predictor variables comprising predictive symptoms and a set of treatment options; b.) developing a trained outcome prediction and an expected response for each treatment option of said set of treatment options, each said trained outcome prediction based upon an automated non-linear analysis of patient symptoms measured in at least one study over time in response to each said treatment option; c.) selecting a first preferred treatment from said set of treatment options based on said trained outcome prediction; d.) applying said first preferred treatment to said clinical patient to obtain a first response; and e.) monitoring said patient by comparing said first response of said clinical patient to said trained outcome prediction for said first preferred treatment to obtain a difference measurement which is used to provide an updated outcome prediction for said clinical patient. - View Dependent Claims (13)
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14. A method of treating a disorder which is diagnosable and treated based upon a patient'"'"'s symptom and for which a patient could have a variable response to treatment, comprising:
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a.) developing an outcome prediction for a set of treatment options and an integrated expected recovery pattern for each treatment option in said set of treatment options, said outcome prediction and said integrated expected recovery pattern for each said treatment option based on computer analysis that utilizes a non-linear algorithm of known patient symptoms and recovery patterns; b.) selecting for said patient a first preferred treatment option from said set of treatment options; c.) generating a first expected recovery pattern associated with said first preferred treatment option, said first expected recovery pattern having a first expected recovery time period; d.) applying said first preferred treatment option to said patient; e.) monitoring said patient during said first expected recovery time period to develop a patient treatment response; f.) comparing said patient treatment response and said first expected recovery pattern; and g.) selecting a second preferred treatment option from said set of treatment options when said patient treatment response varies significantly from said first expected recovery pattern thereby defining a treatment intervention for said patient. - View Dependent Claims (15, 17, 19, 21, 23, 25, 26, 27, 28, 29, 30, 31, 33)
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16. ) determining whether said difference is outside said acceptable range indicating an unacceptable patient recovery pattern;
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4.) selecting a second preferred treatment option from said set of treatment options when said difference is outside said acceptable range. - View Dependent Claims (18)
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20. A method for predicting a response of a patient to a treatment for an affective disorder from at least one pre-treatment clinical symptom, comprising the steps of:
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a.) performing at least one measurement of said pre-treatment clinical symptom on said patient, said pre-treatment symptom being a predictive symptom, and measuring said pre-treatment clinical symptom at selected time intervals so as to derive data representing a baseline patient profile; b.) defining a set of a plurality of predictor variables which define data of said baseline patient profile, said set of predictor variables comprising predictive symptoms and a set of treatment options; c.) deriving a model that represents a relationship between said set of predictor variables and a response exhibited by a recipient of one of said set of treatment options, said relationship derived by using at least one automated non-linear algorithm; and d.) utilizing said model of step c) to predict the response of said patient to said treatment by comparing said model and said baseline patient profile. - View Dependent Claims (22, 24)
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32. A method of treating an affective disorder in a patient comprising the following steps:
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a.) defining a set of predictor variables, said set of predictor variables defining a set of data of a baseline patient profile, said set of predictor variables comprising predictive symptoms and a set of treatment options; b.) developing an outcome prediction for said set of treatment options, said outcome prediction based upon an analysis of patient symptoms, said analysis utilizing an automated nonlinear algorithm; c.) selecting a first preferred treatment option from said set of treatment options based on said outcome prediction; d.) applying said first preferred treatment option to said patient; and e.) monitoring said patient by comparing a response of said patient to said treatment option to said outcome prediction to provide an updated outcome prediction for said patient.
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Specification