Disposable process device

• US 6,063,341 A
• Filed: 06/09/1998
• Issued: 05/16/2000
• Est. Priority Date: 06/09/1997
• Status: Expired due to Term

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Corporation (Roche Holding AG)
• Inventors: Fassbind, Walter, Rey, Werner
• Primary Examiner(s): Spisich, Mark
• Application Number:
  US09/093,776
• Time in Patent Office: 707 Days
• Field of Search: 422/100, 422/102, 422/103, 422/104, 206/514, 206/569, 220/23.83, 220/23.86, 220/23.87, 436/180
• US Class Current: 422/525
• CPC Class Codes: B01L 3/508 rigid containers not provided for above
• CPC Class Codes: B01L 9/06 Test-tube stands; Test-tube holders
• CPC Class Codes: Y10T 436/25 including sample preparation
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A disposable device for carrying out a process in which a biological sample is processed with one or more reagents is described. Contamination-free processing of biological samples is also disclosed.

Claims

1. A device for carrying out a process in which a biological sample is processed with one or more reagents, said device comprising an array of chambers integrally connected to each other;

a cover insert removably connected to the array of chambers; and

a disposable pipetting tip,

said array of chambers comprising

an upper portion shaped as an elongated tray and having an interior delimited by a bottom wall and a side wall which extends perpendicular to and along the perimeter of the bottom wall;

a first process chamber having an open top end and a closed bottom end connected by a tubular wall which extends substantially perpendicular to the bottom wall of said upper portion and downwardly from a first opening in said bottom wall, said first opening forming the open top end of the first process chamber; and

a waste chamber for receiving waste liquids, said waste chamber having an open top end and a closed bottom end connected by a side wall which extends substantially perpendicular to the bottom wall of said upper portion and downwardly from a second opening in said bottom wall, said second opening forming the open top end of the waste chamber;

said cover insert being configured and dimensioned to be inserted in the chamber array and said cover insert comprising

an elongated cover having openings providing access to the process chamber and the waste chamber respectively when said cover insert is inserted in said chamber array, and

a parking chamber for parking therein said disposable pipetting tip, said parking chamber having an open top end and a closed bottom end connected by a tubular wall which extends substantially perpendicular to the cover and downwardly from an opening in the cover; and

said disposable pipetting tip being configured and dimensioned to be at least partially inserted in the interior of the parking chamber.

2. A device according to claim 1, wherein the cover comprises a first channel which provides access to the interior of the first process chamber for dispensing a liquid into this chamber.

3. A device according to claim 1, wherein a portion of the parking chamber is disposed within the waste chamber when said cover insert is inserted into said array of chambers.

4. A device according to claim 1, wherein the first process chamber depends freely downwardly from the bottom wall of said upper portion of said chamber array.

5. A device according to claim 1, wherein said array of chambers further comprises a second process chamber having an open top end and a closed bottom end connected by a tubular wall which extends substantially perpendicular to the bottom wall of said upper portion and downwardly from a third opening in said bottom wall, said third opening forming the open top end of the second process chamber.

6. A device according to claim 5, wherein the bottom wall of said upper portion comprises a second channel which provides access to the interior of the second process chamber for dispensing a liquid into this chamber, this dispensing being effected with a pipetting cannula other than the disposable pipetting tip.

7. A device according to claim 5, wherein the first process chamber, the waste chamber and the second process chamber are arranged linearly.

8. A device according to claim 5, wherein the waste chamber is located between the first process chamber and the second process chamber.

9. A device according to claim 5, wherein the second process chamber depends freely downwardly from the bottom wall of said upper portion of chamber array.

10. A device according to claim 1 or 5, wherein said array of chambers is a single piece of plastic material.

11. A device according to claim 1 or 5, wherein said cover insert is a single piece of plastic material.