Methods and compositions for the modulation of cell proliferation and wound healing
First Claim
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1. An implant comprising:
- at least one agent which modulates proliferation of target cells, wherein said agent is bound to a polymer via a reactive group which mediates an interaction selected from the group consisting of;
a hydrophobic interaction, a hydrophilic interaction, and a covalent interaction, wherein said interaction is labile under physiological conditions, so that said agent is released from said polymer when contacted with a tissue comprising said target cells without the use of an exogenously supplied releasing agent which changes the physiological conditions in said tissue.
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Abstract
Implants which are capable of sustained release of a cell proliferation modulating agent, together with methods for their preparation and use, are provided. The proliferation modulating agent is associated either covalently or non-covalently with the material from which the implant is prepared, generally a biologically inert polymer which is physiologically compatible. The implants are implanted in the tissue, and the drug is released such that the drug is substantially retained within the implant region. The device can be used to inhibit cellular proliferation around the implant. The device can be provided as a sterile kit, preferably in a form suitable for immediate use.
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Citations
33 Claims
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1. An implant comprising:
at least one agent which modulates proliferation of target cells, wherein said agent is bound to a polymer via a reactive group which mediates an interaction selected from the group consisting of;
a hydrophobic interaction, a hydrophilic interaction, and a covalent interaction, wherein said interaction is labile under physiological conditions, so that said agent is released from said polymer when contacted with a tissue comprising said target cells without the use of an exogenously supplied releasing agent which changes the physiological conditions in said tissue.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 26, 27, 28, 29, 30, 31, 33)
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21. An ocular implant comprising:
- at least one agent which modulates proliferation of target cells bound wherein said agent is bound to a polymer via a reactive group which mediates an interaction selected from the group consisting of;
a hydrophobic interaction, a hydrophilic interaction, and a covalent interaction, wherein said interaction is labile under physiological conditions, so that said agent is released from said polymer when contacted with a tissue comprising said target cells without the use of an exogenously supplied releasing agent which changes the physiological conditions in said tissue, and wherein said agent is selected from the group consisting of daunomycin, mitomycin C, doxorubicin, and wherein said polymer is selected form the group consisting of hyaluronic acid, polymethylmethacrylate, hydroxypropylmethylcellulose, carboxymethylcellulose, silicone and nylon. - View Dependent Claims (22, 23, 24)
- at least one agent which modulates proliferation of target cells bound wherein said agent is bound to a polymer via a reactive group which mediates an interaction selected from the group consisting of;
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32. A method of making a polymer implant comprising at least one agent which modulates proliferation of target cells bound wherein said agent is bound to a polymer via a reactive group which mediates an interaction selected from the group consisting of:
- a hydrophobic interaction, a hydrophilic interaction, and a covalent interaction, wherein said interaction is labile under physiological conditions, said method comprising;
contacting a polymer having a sufficient number of reactive groups with a sufficient amount of an agent which modulates proliferation of target cells to form a bond which is labile under physiological conditions, so that said agent is released from said polymer when contacted with a tissue comprising said target cells without the use of an exogenously supplied releasing agent which changes the physiological conditions in said tissue.
- a hydrophobic interaction, a hydrophilic interaction, and a covalent interaction, wherein said interaction is labile under physiological conditions, said method comprising;
Specification