Method of enhancing surface porosity of biodegradable implants
First Claim
1. A method for enhancing surface porosity of a porous biocompatible implant comprising providing said porous biocompatible implant prepared from a polymer having a relatively impermeable surface skin for implantation in the tissue of an animal and removing at least part of said relatively impermeable surface skin of said polymer from at least one surface of the implant.
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Abstract
The invention discloses pH-controlling devices that comprise a biodegradable polymer and a pH-controlling substance, particularly an alkaline, acidic or buffering agents. By way of example, such alkaline agents include calcium carbonate and sodium bicarbonate. Methods of preparing such devices are also described. Methods for enhancing biocompatibility of an implantable device are also provided, as neutralizing alkaline materials are released at a rate that offsets changes in pH typically observed as polymers degrade to various acidic or alkaline by-products. By way of example, biodegradable polymers include PLA, PGA, polycaprolactone, copolymers thereof, or mixtures thereof. A new technique is disclosed to increase the surface porosity of porous implants which have a tendency to form relatively impermeable coverings. This technique entails the use of mechanical means to remove at least part of said covering, thus increasing the implant'"'"'s surface porosity and permeability.
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Citations
3 Claims
- 1. A method for enhancing surface porosity of a porous biocompatible implant comprising providing said porous biocompatible implant prepared from a polymer having a relatively impermeable surface skin for implantation in the tissue of an animal and removing at least part of said relatively impermeable surface skin of said polymer from at least one surface of the implant.
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3. A method for enhancing surface porosity of a porous implant made of a biodegradable polymer having a relatively impermeable surface skin, wherein the biodegradable polymer is polylactic acid, polyglycolic acid, polycaprolactone, a copolymer thereof, or mixture thereof comprising removing at least part of said relatively impermeable surface skin from at least one surface of said implant.
Specification