Method of enhancing surface porosity of biodegradable implants

• US 6,065,476 A
• Filed: 06/01/1995
• Issued: 05/23/2000
• Est. Priority Date: 12/21/1994
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Athanasiou, Kyriacos A., Agrawal, C. Mauli
• Primary Examiner(s): Prebilic, Paul B.
• Application Number:
  US08/457,661
• Time in Patent Office: 1,818 Days
• Field of Search: 623/11, 623/16, 623/901, 128/898, 433/201.1, 433/202.1, 433/203.1
• US Class Current: 128/898
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

The invention discloses pH-controlling devices that comprise a biodegradable polymer and a pH-controlling substance, particularly an alkaline, acidic or buffering agents. By way of example, such alkaline agents include calcium carbonate and sodium bicarbonate. Methods of preparing such devices are also described. Methods for enhancing biocompatibility of an implantable device are also provided, as neutralizing alkaline materials are released at a rate that offsets changes in pH typically observed as polymers degrade to various acidic or alkaline by-products. By way of example, biodegradable polymers include PLA, PGA, polycaprolactone, copolymers thereof, or mixtures thereof. A new technique is disclosed to increase the surface porosity of porous implants which have a tendency to form relatively impermeable coverings. This technique entails the use of mechanical means to remove at least part of said covering, thus increasing the implant'"'"'s surface porosity and permeability.

Claims

1. A method for enhancing surface porosity of a porous biocompatible implant comprising providing said porous biocompatible implant prepared from a polymer having a relatively impermeable surface skin for implantation in the tissue of an animal and removing at least part of said relatively impermeable surface skin of said polymer from at least one surface of the implant.

2. The method of claim 1 wherein the implant is made of a polymer which degrades after implantation in the tissue of an animal.

3. A method for enhancing surface porosity of a porous implant made of a biodegradable polymer having a relatively impermeable surface skin, wherein the biodegradable polymer is polylactic acid, polyglycolic acid, polycaprolactone, a copolymer thereof, or mixture thereof comprising removing at least part of said relatively impermeable surface skin from at least one surface of said implant.