Adaptive brain stimulation method and system
First Claim
1. An adaptive brain stimulation device for treating brain disorder or disfunction comprising:
- a. a sensing means including a sensor or a set of sensors for sensing data used to compute a present state of a patient,b. stimulating means for stimulating a first brain region of the central nervous system of said patient according to a first set of stimulation parameters,c. comparator means for making a statistical comparison operation between said present state and a reference state, said comparison operation resulting in a positive outcome or a negative outcome,e. means for adjusting said stimulation parameters according to the outcome of said comparing said present state to said reference state.
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Abstract
An adaptive brain stimulation system and method is described which aids in the rehabilitation of patients from traumatic brain injury, coma, or other brain dysfunction. After a direct brain stimulator is implanted in a brain region of a patient, the patient is stimulated according to a set of stimulation parameters. A present state is measured and compared to a reference state by statistical and medically relevant criteria. The subsequent program of stimulation is dependent upon the outcome of the comparison. An adaptive brain stimulation and reinforcement system and method is also described in which a second area of the brain is stimulated when stimulation of the first brain area produces a desired effect, thereby reinforcing the prior response of the brain.
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Citations
30 Claims
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1. An adaptive brain stimulation device for treating brain disorder or disfunction comprising:
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a. a sensing means including a sensor or a set of sensors for sensing data used to compute a present state of a patient, b. stimulating means for stimulating a first brain region of the central nervous system of said patient according to a first set of stimulation parameters, c. comparator means for making a statistical comparison operation between said present state and a reference state, said comparison operation resulting in a positive outcome or a negative outcome, e. means for adjusting said stimulation parameters according to the outcome of said comparing said present state to said reference state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An adaptive brain stimulation device comprising:
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a. means for sensing a present state of at least a first brain region, or a fist set of brain regions and a second brain region or a second set of brain regions, b. means for stimulating a first brain region or a first set of brain regions by a direct brain stimulator set #1 according to a first set of stimulation parameters, c. means for stimulating a second brain region or a second set of brain regions by a direct brain stimulator set #2 according to a second set of stimulation parameters, d. means for comparing said present state to a reference state, said comparing leading to a positive outcome or a negative outcome, e. means for adjusting said stimulation parameters according to the outcome of said comparing said present and said reference state.
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- 17. An adaptive brain stimulation device of claim 17 in which said means for stimulation comprises an electrical, magnetic, or pharmacological stimulation means.
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25. A method of using adaptive brain stimulation in the treatment of brain disorder or disfunction which comprises:
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a. sensing the present state of several brain regions, stimulating a first brain region or a first set of brain regions according to a set of stimulation parameters, c. performing a statistical comparison between the present state and a reference table, d. changing said stimulation parameters if the comparison fails to meet a criteria, and e. repeating steps a, b, c, and d. - View Dependent Claims (26, 27)
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28. A method of treating Parkinson'"'"'s Disease and other movement disorders which comprises:
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a. sensing the present state of one or more brain regions and/or peripheral regions, b. stimulating a first brain region or a first set of brain regions according to a set of stimulation parameters, c. performing a statistically significant comparison between the present state and a reference state, d. changing said stimulation parameters if the comparison fails to meet a criteria, and e. repeating steps a, b, c, and d. - View Dependent Claims (29, 30)
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Specification