Reagent handling system and configurable vial carrier for use therein

• US 6,066,300 A
• Filed: 06/18/1998
• Issued: 05/23/2000
• Est. Priority Date: 07/07/1995
• Status: Expired due to Fees

• Current Assignee: Chiron Diagnostics Corp (Bayer AG)
• Original Assignee: Bayer Corporation (Bayer AG)
• Inventors: Weber, David P., Carey, Glen A., Mathis, Scott E.
• Primary Examiner(s): Le, Long V.
• Application Number:
  US09/099,368
• Time in Patent Office: 705 Days
• Field of Search: 422/104, 422/63, 422/65, 422/102, 422/67, 436/47, 436/48, 436/50, 206/443, 206/459.5, 206/485, 211/60.1, 211/74, 235/375, 235/462, 235/486, 235/383, 235/385
• US Class Current: 422/560
• CPC Class Codes: B01F 2101/23 Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
• CPC Class Codes: B01F 33/50 Movable or transportable mixing devices or plants
• CPC Class Codes: B01F 35/50 Mixing receptacles
• CPC Class Codes: B01L 9/06 Test-tube stands; Test-tube holders
• CPC Class Codes: G01N 2035/00514 Stationary mixing elements
• CPC Class Codes: G01N 2035/00524 Mixing by agitating sample carrier
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers
• CPC Class Codes: G01N 35/1002 Reagent dispensers
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/115831 Condition or time responsive

Abstract

A vial carrier having plural reagent compartments disposed linearly along the length of the carrier. Each compartment is adapted for receiving one of plural reagent vials. The carrier is provided with indicia uniquely identifying it to an automated assay device. Similarly, each compartment of the carrier has associated with it indicia which are at least unique to the particular carrier. Lastly, each vial installable within a carrier compartment has indicia unique to the contents of the vial. A film seal is applied to the vial opening prior to an integrated cap/seal assembly for the purpose of ensuring that the assembly is liquid-tight. The carrier is configured to be disposed on a slide of an inclining tray within an enclosure. Data reflecting which vial is located in which compartment of a given carrier is collected and provided to the automated instrument prior to installation of the carrier into the enclosure. The automated instrument has, associated with the enclosure, an indicia recognition element to identify each installed carrier. In this manner, the instrument has information reflecting that a desired vial is installed in a particular compartment of a carrier which is installed on a particular slide within the enclosure.

Claims

1. A vial carrier for use in conjunction with an automated liquid handling system, comprising:

an elongate body having a first end and a second end and two parallel sidewalls disposed therebetween;

a handle disposed on said first end; and

a plurality of vial compartments linearly disposed along said elongate body,

wherein each of said vial compartments is configured for receiving and retaining a respective liquid-bearing vial, is provided with a slot, formed in a first of said elongate body sidewalls, for exposing a first portion of a respective vial compartment to external view, and is provided with a notch, formed at an upper edge of a second of said elongate body sidewalls, for exposing a second portion of said respective vial compartment to external view.

2. The vial carrier of claim 1, wherein each liquid-bearing vial is provided with a label identifying, in machine readable form, the contents thereof, said label configured to appear within said slot of said respective compartment when said vial is disposed therein.

3. The vial carrier of claim 1, wherein each of said vial compartments further comprises a retention element having an indexing member projecting toward the interior of the respective vial compartment and adapted for releasably retaining a respective vial in a first position upon installation of said vial within said compartment through cooperative engagement of said indexing member with a circumferential groove disposed proximate a lower edge of said vial.

4. The vial carrier of claim 1, further comprising an indicia uniquely identifying each of said compartments.

5. The vial carrier of claim 1, further comprising an indicia uniquely identifying said vial carrier among a plurality of said vial carriers.

6. The vial carrier of claim 1, wherein each of said vials further comprises:

a liquid extraction orifice;

a liquid-tight film overlying said orifice;

a pierceable seal disposed over said film and said orifice; and

a resilient cap for retaining said seal over said film and said orifice.

7. The vial carrier of claim 1, wherein each liquid-bearing vial is provided with a label identifying, in human readable form, the contents thereof, said label configured to appear within said notch of said respective compartment when said vial is disposed therein.

8. The vial carrier of claim 1, wherein said elongate body is further comprised of a bottom surface having a respective aperture disposed beneath each compartment, each aperture providing accessibility to a bottom surface of a vial disposed in a respective compartment.