System and method for multiple site biphasic stimulation to revert ventricular arrhythmias

• US 6,067,470 A
• Filed: 03/05/1998
• Issued: 05/23/2000
• Est. Priority Date: 03/05/1998
• Status: Expired due to Term

• Current Assignee: MR3 Medical, LLC
• Original Assignee: Mower Family Chf Treatment Irrevocable Trust
• Inventors: Mower, Morton M.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/035,455
• Time in Patent Office: 810 Days
• Field of Search: 607/4, 607/5, 607/6, 607/7, 607/8, 607/9
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

An anti-reentry apparatus and method for reverting ventricular arrhythmias. Biphasic stimulation is applied at multiple ventricular sites to revert arrhythmias caused by reentry, particularly multiple random reentry. In the preferred embodiment, the first phase of biphasic stimulation is anodal, and is at a maximum subthreshold amplitude. The anodal phase preconditions the myocardium to accept the second phase (cathodal) such that less electrical energy is required to reach the threshold amplitude to produce depolarization. The anodal phase stimulation may have a shape over time that is square wave, ramped, or a series of short square wave pulses. Multiple electrodes located at multiple ventricular sites may be stimulated simultaneously, or they may be sequentially stimulated over time in a manner mimicking the normal progress pattern of cardiac depolarization. The multiple ventricular electrodes may stimulate from internal or external surfaces. One or both ventricles may receive biphasic stimulation from multiple electrodes. The invention also may be practiced with respect to atria.

Claims

1. A method for biphasic myocardial stimulation, comprising:

(a) at least two electrodes administering a first stimulation phase having a first phase polarity, a first phase amplitude, a first phase shape, and a first phase duration for preconditioning the myocardium to accept subsequent stimulation;

(b) the at least two electrodes administering a second stimulation phase having a second phase polarity, a second phase amplitude that is larder in absolute value than the first phase amplitude, a second phase shape, and a second phase duration;

(c) sensing for fibrillation; and

(d) repeating steps a), b), and c) if fibrillation is sensed.

2. The method for myocardial stimulation according to claim 1, where the first phase polarity is positive, and the second phase polarity is negative.

3. The method for myocardial stimulation according to claim 2, where the first phase amplitude is at a maximum subthreshold amplitude.

4. The method for myocardial stimulation according to claim 3, where the maximum subthreshold amplitude is about 0.5 volt to about 3.5 volts.

5. The method for myocardial stimulation according to claim 1, where the first phase shape is ramped from a baseline value to a second value.

6. The method for myocardial stimulation according to claim 5, where the second value is not more than a maximum subthreshold amplitude.

7. The method for myocardial stimulation according to claim 1, where the first phase duration is about one millisecond to about nine milliseconds.

8. The method for myocardial stimulation according to claim 1, where the second phase amplitude is about two volts to about twenty volts.

9. The method for myocardial stimulation according to claim 1, where the second phase duration is about 0.2 millisecond to about 1.5 milliseconds.

10. The method for myocardial stimulation according to claim 1, where the first stimulation phase further comprises a series of stimulating pulses of a predetermined amplitude and duration, and a series of rest periods.

11. The method for myocardial stimulation according to claim 10, where applying the first stimulation phase further comprises applying a rest period after at least one stimulating pulse.

12. The method for myocardial stimulation according to claim 10, where the predetermined duration is about 0.2 millisecond to about 1.5 milliseconds.

13. The method for myocardial stimulation according to claim 10, where the rest period is about 0.2 millisecond to about 1.2 milliseconds.

14. The method for myocardial stimulation according to claim 1, where the first phase shape is selected from the group consisting of square wave pulse, ramped pulse, and series of short duration square wave pulses.

15. The method for myocardial stimulation according to claim 1, where at least one of the electrodes is applied to an inner ventricular wall via the vena cava.

16. The method for myocardial stimulation according to claim 1, where at least one of the electrodes is applied to an exterior ventricular wall.

17. The method for myocardial stimulation according to claim 1, where the stimulation is applied to the electrodes progressively in a manner that mimics the normal flow of electrical depolarization in a heart.

18. The method for myocardial stimulation according to claim 17, where:

the electrodes closest to the A-V node are the first to be fired;

the electrodes farthest from the A-V node, following the normal intrinsic conduction paths, are the last to be fired; and

the electrodes intermediate between the electrodes closest to the A-V node and the electrodes farthest from the A-V node are fired at an intermediate time that is proportional to their intermediate position, following the normal intrinsic conduction paths.

19. The method for myocardial stimulation according to claim 18, where the electrodes are ordered by class according to their distance from the A-V node, following the normal intrinsic conduction paths.

20. The method for myocardial stimulation according to claim 19, where the number of classes is between two and about thirty.

21. The method for myocardial stimulation according to claim 1, where the second phase amplitude is larger in absolute value than the first phase amplitude.

22. A method for reverting ventricular arrhythmias with biphasic waveforms, comprising:

at least two electrodes administering a first stimulation phase having a positive polarity, a subthreshold amplitude, a duration of about one millisecond to about nine milliseconds, and a shape, wherein the shape is selected from the group consisting of square wave pulse, ramped pulse, and series of short duration square wave pulses; and

the at least two electrodes administering a second stimulation phase having a negative polarity, an amplitude of about two volts to about twenty volts that is larger in absolute value than the first stimulation chase subthreshold amplitude, and a duration of about 0.2 millisecond to about 1.5 milliseconds.