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Breath test for the diagnosis of Helicobacter pylori infection in the gastrointestinal tract

  • US 6,067,989 A
  • Filed: 02/26/1997
  • Issued: 05/30/2000
  • Est. Priority Date: 02/26/1997
  • Status: Expired due to Term
First Claim
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1. A method for the diagnosis of Helicobacter Pylori in the gastrointestinal tract of a subject, comprising the steps of:

  • (a) administering isotope-labeled urea to the subject, said isotope-labeled urea being cleavable by urease to form a cleavage product;

    (b) having said subject exhale repeatedly into analyzing equipment;

    (c) analyzing a plurality of exhaled breaths of the subject substantially in real time while the subject'"'"'s exhalation contains the cleavage product, if present, to determine a plurality of concentrations of said cleavage product; and

    (d) analyzing said plurality of concentrations to indicate Helicobacter Pylori activity in the gastrointestinal tract of said subject, wherein the step of analyzing said exhaled breath of the subject is repeated substantially continuously until a predetermined accuracy for analyzing said plurality of concentrations is reached.

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