Method and apparatus for determining airway resistance and lung compliance

• US 6,068,602 A
• Filed: 09/26/1997
• Issued: 05/30/2000
• Est. Priority Date: 09/26/1997
• Status: Expired due to Fees

• Current Assignee: Datex-Ohmeda Incorporated (GE Healthcare Technologies, Inc.)
• Original Assignee: Ohmeda, Inc. (Linde Plc)
• Inventors: Tham, Robert Q., Theisen, William M., Bathe, Duncan P. L.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US08/938,162
• Time in Patent Office: 977 Days
• Field of Search: 600/529, 600/533, 600/538
• US Class Current: 600/533
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity

Abstract

A method and apparatus is disclosed for determining airway resistance and lung compliance using an electrical circuit model wherein at least one component parameter is non-linear. The system non-intrusively obtains pressure and flow data signals from a pressure transducer and a laminar flow element without interrupting or interfering with normal breathing and gas supply to a patient. An invariant exponential is determined empirically based on physical characteristics of the airway. The non-linear airway resistance and lung compliance can then be calculated based on the sensed flow rate, gas pressure, a calculated gas volume, and the invariant exponential using linear techniques. The resulting airway resistance can be normalized to a standard reporting flow rate value. The system is particularly useful in anesthesia applications, but is also useful in any breathing system where fresh gas is supplied constantly from a gas source other than a ventilator.

Claims

1. A method of establishing the airway resistance and lung compliance of a subject using a non-linear circuit model, the subject inspiring and expiring breathing gases through an airway, said method comprising the steps of:

sensing breathing gas flow rate through the airway;

sensing breathing gas pressure in the airway;

calculating a gas volume moved through the airway from the sensed breathing gas flow rate;

determining an invariant exponential based on physical characteristics of the airway; and

calculating airway resistance and lung compliance based on the gas flow rate, the gas pressure, the gas volume, and the invariant exponential.

2. The method of claim 1 wherein the step of sensing gas flow rate and pressure are further defined as sensing the breathing gas flow rate and pressure in an airway having an endotracheal tube.

3. The method of claim 1 wherein the step of calculating gas volume further comprises the steps of:

differentiating between expiration and inspiration flow;

multiplying each sensed expiration gas flow rate by a corresponding sampling time to obtain a current gas volume sample; and

integrating a series of current gas volume samples during an expiration cycle to obtain the calculated gas volume.

4. The method of claim 1 further comprising the steps of:

acquiring at least three sets of data from the sensing steps; and

forming a matrix of the acquired data for calculating the airway resistance and lung compliance.

5. The method of claim 1 further comprising the steps of:

acquiring at least three sets of data from the sensing steps; and

regressively calculating the airway resistance and lung compliance using the acquired data.

6. The method of claim 1, wherein the airway is tubular and the invariant exponential is determined at approximately 1.7.

7. The method of claim 1 wherein the step of calculating airway resistance and lung compliance is further defined as solving the equation:

space="preserve" listing-type="equation">P.sub.aw =L+1/C.sub.L *v(t)+K.sub.P *f(t).sup.n

where P_aw is the sensed airway pressure, v(t) is the calculated airway volume, f(t) is the flow rate, n is the invariant exponential, L is a constant term, C_L is the lung compliance, and K_P is the airway resistance.

8. The method of claim 7 wherein the airway resistance is normalized to a standard flow rate given by:

space="preserve" listing-type="equation">R.sub.P =K.sub.P *F.sub.ref.sup.n-1

where F_ref^n-1 is a referenced flow rate and R_P is the normalized airway resistance.

9. The method of claim 1 wherein the step of determining an invariant exponential is dependent on a shape and size of the airway and is determined empirically.

10. An apparatus to determine the airway resistance and lung compliance of a subject using a non-linear circuit model, the subject inspiring and expiring breathing gases through an airway, said apparatus comprising:

a breathing gas flow rate sensor attachable to the airway to sense a gas flow therethrough and produce a flow rate signal therefrom;

a breathing gas pressure sensor locatable in the airway to sense a gas pressure therein and produce a pressure signal therefrom; and

a processor connected to the gas flow and pressure sensors to receive the flow and pressure signals, the processor calculating a gas volume moved through the airway and employing an invariant exponential based on the physical characteristics of the airway to calculate airway resistance and lung compliance using the gas flow rate, the gas pressure, the gas volume, and the invariant exponential.

11. The apparatus of claim 10, wherein the airway is tubular shaped and the invariant exponential is approximately 1.7.

12. The apparatus of claim 10 wherein the processor carries out the airway resistance and lung compliance calculation using the equation:

space="preserve" listing-type="equation">P.sub.aw =L+1/C.sub.L *v(t)+K.sub.P *f(t).sup.n-1

where P_aw is the sensed airway pressure, v(t) is the calculated airway volume, f(t) is the flow rate, n is the invariant exponential, L is a constant term, C_L is the lung compliance, and K_P is the airway resistance.

13. The apparatus of claim 12 wherein the airway resistance is normalized to a standard flow rate given by:

space="preserve" listing-type="equation">R.sub.P =K.sub.P * F.sub.ref.sup.n-1

where F_ref^n-1 is a referenced flow rate and R_P is the normalized airway resistance.

14. The apparatus of claim 10 further comprising:

a signal conditioner to filter errant and noise signals received from the sensors; and

an A/D converter connected to receive analog signals from the gas flow rate sensor and the gas pressure sensor and produce digital signals in response.

15. The apparatus of claim 10 wherein the processor initially calculates a gas volume from the received flow rate signals.

16. The apparatus of claim 10 wherein the processor calculates the gas volume by:

differentiating between expiration and inspiration breathing gas flow;

multiplying each sensed expiration gas flow rate by a corresponding sampling time to obtain a current gas volume sample; and

integrating a series of current gas volume samples during an expiration cycle to obtain the calculated gas volume.

17. The apparatus of claim 10 wherein the airway is an endotracheal tube.

18. The apparatus according to claim 10 wherein said processor is further defined as calculating airway resistance and lung compliance using at least three sets of data and forming a matrix of the data.

19. The apparatus of claim 10 wherein said processor is further defined as calculating airway resistance and lung compliance using at least three sets of data and regressively calculating the airway resistance and lung compliance using the data.