Plastic syringe with overcap

• US 6,068,614 A
• Filed: 06/23/1997
• Issued: 05/30/2000
• Est. Priority Date: 11/03/1994
• Status: Expired due to Fees

• Current Assignee: Astra Pharmaceuticals LP (Astrazeneca PLC)
• Original Assignee: Astra Pharmaceuticals LP (Astrazeneca PLC)
• Inventors: Kimber, Michael Browning, Popovsky, Frank Alexander
• Primary Examiner(s): STRIGHT, RONALD K
• Application Number:
  US08/836,079
• Time in Patent Office: 1,072 Days
• Field of Search: 604/110, 604/181, 604/187, 604/192, 604/199, 604/200, 604/236, 604/238, 604/244, 604/256, 604/263, 604/111, 215/DIG. 3, 215/211, 215/249, 215/250, 215/251, 215/253, 215/354, 215/316, 215/320, 215/325, 264/464, 264/478, 264/176.1, 264/211.12, 264/209.1
• US Class Current: 604/200
• CPC Class Codes: A61M 2005/3104 Caps for syringes without needle
• CPC Class Codes: A61M 2005/3106 Plugs for syringes without needle
• CPC Class Codes: A61M 5/178 Syringes
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms

Abstract

A plastic pre-filled syringe which includes an open ended barrel sealed at one end by a moveable stopper and sealed at the other end by a closure frangibly connected to the syringe. The syringe also includes an overcap which can be moved so to engage with the closure whereby removal of the overcap will cause the closure to be separated from the rest of the syringe and reveal the contents for injection.

Claims

1. A plastic pre-filled syringe which includes:

(a) an open ended barrel sealed at one end by a moveable stopper and sealed at the other end by a closure frangibly connected to the syringe; and

(b) an overcap which includes closure retention means able to hold and retain at least the end of the closure;

wherein said overcap is moveable from a first position, from which removal of said overcap will not cause the frangible connection of the closure to the syringe to be broken, to a second position in which the closure is held and retained by the closure retention means and from which removal of the overcap will cause the closure to be separated from the rest of the syringe so to reveal the contents for injection.

2. A plastic syringe as claimed in claim 1 wherein the closure is in the form of a stem which extends outwardly from the end of the syringe remote from the stopper.

3. A plastic syringe as claimed in claim 2 wherein the closure retention means is a hollow channel within the overcap into which the stem can be inserted.

4. A plastic syringe as claimed in claim 3 wherein the hollow channel includes a portion which is tapered internally so that it progressively narrows in diameter.

5. A plastic syringe as claimed in claim 4 wherein the stem is between 1.5 mm to 2.3 mm in maximum cross-section and the channel in the overcap includes a section which is at least 0.1 mm smaller in maximum cross section than the stem.

6. A plastic syringe as claimed in claim 5 wherein the stem is between 1.8 mm to 2.1 mm in maximum cross-section.

7. A plastic syringe as claimed in claim 1 wherein the closure end of the syringe includes a fitting suitable for accommodating a hypodermic needle.

8. A plastic syringe as claimed in claim 7 wherein the fitting is a luer-lock needle fitting which includes a hollow conical section and a peripheral outer wall.

9. A plastic syringe as claimed in claim 8 wherein the overcap includes a depending peripheral skirt which is of such diameter and thickness to fit between the hollow conical section and the peripheral outer wall of the needle fitting.

10. A plastic syringe as claimed in claim 8 wherein the overcap includes a depending peripheral skirt which is of such diameter to fit over the outside of the peripheral outer all of the needle fitting.

11. A plastic syringe as claimed in claim 1 wherein the closure is frangibly connected to the end of the syringe by a bridging portion of plastics material which extends from the inner wall of an exit orifice at the end of the syringe to the outer wall of the closure.

12. A plastic syringe as claimed in claim 11 wherein the bridging portion comprises a section of minimum cross-section and another section which increases in thickness away from the section of minimum cross section.

13. A plastic syringe as claimed in claim 1 wherein the closure comprises a plurality of longitudinal grooves each separated by a compressible fin.

14. A plastic syringe as claimed in claim 1 wherein the overcap is secured into position over the closure.

15. A plastic syringe as claimed in claim 1 wherein said syringe is made exclusively from polypropylene, polyethylene or polyethylene terephthalate.

16. A method of manufacturing a plastic pre-filled syringe which includes:

i) injection moulding in an aseptic environment an open ended barrel sealed at one end by an integral closure frangibly connected to the barrel;

ii) aseptically filling the barrel with an injectable medium in said aseptic environment;

iii) introducing into the aseptic environment a pre-sterilized stopper;

iv) fitting the pre-sterilized stopper into the open end of the barrel in the aseptic environment;

and either before, during or after the filling of the barrel separately injection moulding an overcap which includes closure retention means and fitting said overcap over the closure, and connecting it to the closure end of the barrel.

17. A method as claimed in claim 16 wherein said overcap is moulded within the same aseptic environment as that in which the open ended barrel is injection moulded and the overcap is connected to the closure end of the barrel within said aseptic environment.