Temporally controlled drug delivery systems
First Claim
1. A transdermal delivery device for the passive, temporal or periodic control of delivery of active agents, comprising:
- a) a first species, which is an active agent, to be delivered from said transdermal device or a second species to be modified in situ into said first species,b) some or all of the initial reactants of an oscillation reaction such that said oscillation reaction is not initiated until desired; and
c) means for separating at least one of said initial reactants from the remainder of said initial reactants prior to activation of said oscillation reaction within said transdermal device when all of said initial reactants are contained within said transdermal device prior to activation or means for introducing any of said initial reactants of said oscillation reaction which are not otherwise present in said transdermal device prior to activation;
whereby said oscillation reaction can be activated by bringing together all of said initial reactants or exposing said initial reactants to an activating condition and said delivery of said first species is passively controlled in response to said oscillations of said oscillation reaction.
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Accused Products
Abstract
A delivery mechanism and device for the passive periodic release of a drug or an active ingredient which avoids the need for external power sources and/or electronic controllers. By taking advantage of oscillating chemical systems, one can change the state, i.e. the pH, of a solution, a drug, enhancer or solubilizer resulting in oscillating the ability of an active ingredient to be delivered transdermally. The pH of a solution can be oscillated over a range of pH values from 2 to 10 by the reduction and oxidation (redox) reactions of salts, such as permanganates, iodates, sulfates, chlorates, or bromates. Upon activation, the delivery system conditions begin to oscillate and with it, the delivery of the active agent oscillates.
183 Citations
14 Claims
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1. A transdermal delivery device for the passive, temporal or periodic control of delivery of active agents, comprising:
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a) a first species, which is an active agent, to be delivered from said transdermal device or a second species to be modified in situ into said first species, b) some or all of the initial reactants of an oscillation reaction such that said oscillation reaction is not initiated until desired; and c) means for separating at least one of said initial reactants from the remainder of said initial reactants prior to activation of said oscillation reaction within said transdermal device when all of said initial reactants are contained within said transdermal device prior to activation or means for introducing any of said initial reactants of said oscillation reaction which are not otherwise present in said transdermal device prior to activation; whereby said oscillation reaction can be activated by bringing together all of said initial reactants or exposing said initial reactants to an activating condition and said delivery of said first species is passively controlled in response to said oscillations of said oscillation reaction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification