Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object

• US 6,069,698 A
• Filed: 08/27/1998
• Issued: 05/30/2000
• Est. Priority Date: 08/28/1997
• Status: Expired due to Term

• Current Assignee: Olympus Optical Company Ltd. (Olympus Corporation)
• Original Assignee: Olympus Optical Company Ltd. (Olympus Corporation)
• Inventors: Ueno, Hitoshi, Ohno, Masahiro, Takizawa, Hironobu, Hibino, Hiroki, Kaneko, Mamoru, Horii, Akihiro, Mizuno, Hitoshi, Adachi, Hideyuki, Yoshino, Kenji, Kawai, Toshimasa, Ozawa, Takeshi, Uesugi, Takefumi, Takehana, Sakae, Hirao, Isami, Imaizumi, Katsuichi, Sangu, Hiroyuki, Yasuda, Eiji, Aoki, Hidemichi, Hiroya, Jun, Oaki, Yoshinao
• Primary Examiner(s): Kim, Robert H.
• Assistant Examiner(s): Lee, Andrew H.
• Application Number:
  US09/141,430
• Time in Patent Office: 642 Days
• Field of Search: 356/345, 356/351, 356/354, 356/357
• US Class Current: 356/511
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: G01B 2290/35 Mechanical variable delay line
• CPC Class Codes: G01B 2290/65 Spatial scanning object beam
• CPC Class Codes: G01B 9/0205 of probe head
• CPC Class Codes: G01B 9/02064 by particular adjustment of coherence gate, i.e. adjusting position of zero path difference in low coherence interferometry
• CPC Class Codes: G01B 9/02069 Synchronization of light source or manipulator and detector
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence

Abstract

A low coherence beam emitted by a low coherence light source is split into two portions. One portion is transmitted from the outward end of a first single mode fiber via a detachable connector to a beam scanning probe, and then to a biological tissue; and the other is transmitted from an optical coupler placed midway along the light path via a second single mode fiber to a light path modifier. The light path modifier includes a galvanometer mirror to modify the light path length in accordance with a scan range, and a uniaxial stage to adjust the light path length to absorb the variation in lengths of different beam scanning probes. The light path is adjusted by the uniaxial stage such that the beam interference is detected for the scan range, to ensure stable acquisition of tomographic images.

Claims

1. An optical imaging apparatus comprising:

a light source to generate a low coherence light beam;

an optical probe which incorporates a sample beam transmitter which includes a single mode fiber to transmit a sample beam containing the low coherence light beam to a test sample, and to also transmit the sample beam upon being reflected by the test sample;

a coupler which is detachably connectable to the optical probe via an optical connector and which allows the reflected sample beam and a reference beam containing the low coherence light beam to interfere with each other;

a detector which detects the interfering beams;

an image signal generator to generate image signals on the basis of signals detected by the detector;

a first transmission time altering unit which alters the transmission time of the reference beam in accordance with a scan range of the optical probe so that the interference between the reflected beam and the reference beam takes place within the scan range in the axial direction with respect to the optical light paths of the sample beam and the reference beam, and

a second transmission time altering unit to alter the transmission time of the reference beam in accordance with a light path length of the sample beam transmitter.

2. The optical imaging apparatus of claim 1, wherein

the coupler functions as a low coherence light beam splitter to split the low coherence light beam generated by the light source to form the sample beam and the reference beam;

and

the low coherence light beam splitter transmits the sample beam via the optical connector to the sample beam transmitter of the optical probe and transmit the reference beam to the first transmission time altering unit and the second transmission time altering unit.

3. The optical imaging apparatus of claim 2, wherein

the low coherence light beam splitter is optically connected to one end of each of a first through a fourth single mode fiber;

the other end of the first single mode fiber is optically connected to the light source;

the other end of the second single mode fiber is optically connected to the sample beam transmitter;

the other end of the third single mode fiber is optically connected to the first transmission time altering unit and the second transmission time altering unit; and

the other end of the fourth single mode fiber is optically connected to the detector which detects an interference between the reflected beam and the reference beam.

4. The optical imaging apparatus of claim 1, further comprising a third transmission time altering unit to alter the transmission time of the reference beam in accordance with the light path of sample beam transmitter.

5. The optical imaging apparatus of claim 4, wherein

the coupler functions as a low coherence light beam splitter to split the low coherence light beam generated by the light source into the sample beam and the reference beam;

and

the low coherence light beam splitter transmits the sample beam via the optical connector to the sample beam transmitter of the optical probe and transmits the reference beam to the first transmission time altering unit, the second transmission time altering unit, and the third transmission time altering unit.

6. The optical imaging apparatus of claim 4, wherein

the third transmission time altering units includes an optical delay section to alter the transmission time of the reference beam by switching to a particular delay time among a plurality of predetermined delay times in accordance with a given type of optical probe.

7. The optical imaging apparatus of claim 5, wherein

the third transmission time altering unit includes an optical delay section to alter the transmission time of the reference beam by switching to a particular delay time among a plurality of predetermined delay times in accordance with a given type of optical probe.

8. The optical imaging apparatus of claim 5, wherein

the low coherence light beam splitter is optically connected to one end of each of a first through a fourth single mode fibers;

the other end of the first single mode fiber is optically connected to the light source;

the other end of second single mode fiber is optically connected to the sample beam transmitter;

the other end of third single mode fiber is optically connected to the first transmission time altering unit, the second transmission time altering unit, and the third transmission time altering unit; and

the other end of fourth single mode fiber is optically connected to the detector which detects an interference fringe between the reflected beam and the reference beam.

9. The optical imaging apparatus of claim 6, wherein

the optical delay section includes a combination of optical switches and a plurality of single mode fibers having different respective lengths.

10. The optical imaging apparatus of claim 7, wherein

the optical delay section includes a combination of optical switches and a plurality of single mode fibers having different respective lengths.

11. The optical imaging apparatus of claim 1, wherein

the first and second transmission time altering units include a galvanometer moving mirror and a uniaxial moving stage, respectively.

12. The optical imaging apparatus of claim 1, wherein

the first transmission time altering unit is a combination of a piezo element and a single mode fiber;

and

the second transmission time altering unit is a uniaxial moving stage.

13. The optical imaging apparatus of claim 1, wherein

the first transmission time altering unit is a galvanometer moving mirror;

and

the second transmission time altering unit is a combination of a light reflecting member and a uniaxial moving stage.

14. The optical imaging apparatus of claim 1, wherein

the optical probe is a slender, soft and cylindrical sheath which can be inserted into a forceps channel of an endoscope.

15. The optical imaging apparatus of claim 14, further comprising:

a freely rotatable flexible shaft; and

a single mode fiber within the sheath to scan a beam by rotation in the radial direction of the sheath; and

a detachable optical connector on the proximal end of the fiber.

16. The optical imaging apparatus of claim 1, wherein

the first transmission time altering unit is capable of rapidly altering the transmission time of the reference beam in accordance with the scan range.

17. The optical imaging apparatus of claim 1, wherein

the first transmission time altering unit is capable of rapidly and periodically altering the transmission time of the reference beam in accordance with the scan range.

18. The optical imaging apparatus of claim 1, wherein

the second transmission time altering unit is so adjustable as to be capable of altering the transmission time of the reference beam within a range defined a target portion of a test object so that tomographic images of that portion may be obtained.

25. The optical imaging apparatus of claim 1, wherein

the optical probe has a sufficiently slender insert so as to be introducible into a test sample body;

the probe includes;

at least one beam scanning elements affixed to a silicone substrate inserted at the tip of the insert in order to scan the sample beam transmitted via the sample beam transmitter over the test sample; and

at least one lenses inserted at the tip of the insert in order to focus the sample beam transmitted via the sample beam transmitter onto the test sample, and to direct the sample beam upon being reflected by the test sample.

26. The optical imaging apparatus of claim 25, wherein

the at least one beam scanning elements are activated through a static electrical force or a magnetic force.

27. The optical imaging apparatus of claim 25, wherein

the at least one beam scanning elements includes two scanning elements to scan the sample beam in a two-dimensional plane tangential to the surface of the test sample.

28. The optical imaging apparatus of claim 25, wherein

the at least one lens is inserted between the sample beam transmitter and the at least one beam scanning elements.

29. The optical imaging apparatus of claim 25, wherein

the at least one lens is inserted between the at least one beam scanning elements and the test sample.

30. The optical imaging apparatus of claim 29, wherein

the at least one lens, the at least one beam scanning elements and the sample beam transmitter are integratively combined to form a beam radiating section, the beam radiating section further including:

means to change the position of the beam radiating section in order to alter the distance between the at least one lens and the test sample.

31. The optical imaging apparatus of claim 1, wherein the optical probe comprises:

a slender, soft and cylindrical sheath with a blunt tip which can be introduced into a forceps channel of an endoscope, and which has at least the lateral wall of its tip made of a material which is transmissive to light;

a lens which is fixed towards the tip of the sample beam transmitter to focus the sample beam emanating from the sample beam transmitter at a specific position;

an ultrasonic motor installed in the interior of the tip of the sheath and including a rotor;

a power source to supply electricity to the ultrasonic motor and a controller therefor;

light path modifying unit fixed to the rotor of the ultrasonic motor to alter the light path of a light beam passing through the lens through the rotation of the ultrasonic motor.

32. The optical imaging apparatus of claim 31, wherein

the sheath comprises

a soft tube which is open at both ends, and

a cap which is transmissive to light, the cap being attached to one end of the tube.

33. The optical imaging apparatus of claim 31, wherein

the material of the sheath is formed from a material selected from the group consisting of polymethyl pentane, polyamide, FEP, TPFE or PFA.

34. The optical imaging apparatus of claim 31, wherein

the sheath comprises

a soft tube which is open at both ends,

a pipe made of a material which is transmissive to light and connected to one end of the tube, and

a cap enclosed in one end of the pipe.

35. The optical imaging apparatus of claim 34, wherein

the pipe is made of fused quartz.

19. An optical imaging apparatus comprising:

a light source to generate a low coherence light beam;

an optical probe which incorporates a sample beam transmitter which includes a single mode fiber to transmit a sample beam containing the low coherence light beam to a test sample and to transmit the sample beam upon being reflected by the test sample;

a coupler which is detachably connectable to the optical probe via an optical connector and which allows the reflected sample beam and a reference beam containing the low coherence light beam to form an interference fringe;

a detector which detects the interference fringe;

an image signal generator to generate image signals on the basis of signals detected by the detector;

a first transmission time altering unit which alters the transmission time of the reference beam in accordance with a scan range of the optical probe so that the interference between the reflected beam and the reference beam takes place within the scan range in the axial direction with respect to the optical light paths of the sample beam and the reference beam; and

a second transmission time altering unit to alter the transmission time of the reference beam in accordance with a light path length of the sample beam transmitter.

20. The optical imaging apparatus of claim 19, wherein

the coupler functions as a low coherence light beam splitter to split the low coherence light beam generated by the light source into the sample beam and the reference beam;

and

the low coherence light beam splitter transmits the sample beam via the second transmission time altering unit and the optical connector to the sample beam transmitter of the optical probe and transmits the reference beam to the first transmission time altering unit.

21. The optical imaging apparatus of claim 20, wherein

the low coherence light beam splitter is optically connected to one end of each of a first through a fourth single mode fiber;

the other end of the first single mode fiber is optically connected to the light source;

the other end of the second single mode fiber is optically connected to the sample beam transmitter;

the other end of the third single mode fiber is optically connected to the first transmission time altering unit; and

the other end of the fourth single mode fiber is optically connected to the detector which detects an interference between the reflected beam and the reference beam.

22. An optical imaging apparatus comprising:

a light source to generate a low coherence light beam;

an optical probe which incorporates a sample beam transmitter which includes a single mode fiber to transmit a sample beam containing the low coherence light beam to a test sample and to transmit the sample beam upon being reflected by the test sample;

a coupler which is detachably connectable to the optical probe via an optical connector and which allows the reflected sample beam and a reference beam containing the low coherence light beam to form an interference fringe;

a detector which detects the interference fringe;

an image signal generator to generate image signals on the basis of signals detected by the detector;

a first transmission time altering unit which alters the transmission time of the reference beam in accordance with a scan range of the optical probe so that the interference between the reflected beam and the reference beam takes place within the scan range in the axial direction with respect to the optical light paths of the sample beam and the reference beam; and

a second transmission time altering unit to alter the total transmission time of the low coherence light beam and the reflected beam in accordance with a light path length of the sample beam transmitter.

23. The optical imaging apparatus of claim 22 wherein the optical probe

a rotatable prism mirror in the tip thereof to reflect the sample beam in radial directions,

fluid storing section disposed on the back side of a reflective surface of the prism mirror, and

a fluid with a low refractive index stored in the fluid storing section.

24. The optical imaging apparatus of claim 23, wherein

the fluid with a low refractive index is air.