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Oral delivery composition comprising supramolecular complex

  • US 6,071,538 A
  • Filed: 09/30/1997
  • Issued: 06/06/2000
  • Est. Priority Date: 06/15/1992
  • Status: Expired due to Term
First Claim
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1. A method for preparing an orally administrable biologically active agent, said method comprising:

  • exposing a biologically active agent, which can exist in (i) a native conformational state, (ii) a denatured conformational state. and (iii) an intermediate conformational state, to acomplexing perturbant to reversibly transform said biologically active agent to said intermediate state and to form a transportable suprarnolecular complex,said intermediate conformational state being reversible to said native state and said intermediate conformational state being between said native and denatured states,said perturbant having a molecular weight ranging from about 150 to about 600 daltons, and having at least one hydrophilic moiety and at least one hydrophobic moiety,said supramolecular complex comprising said perturbant non-covalently complexed with said biologically active agent; and

    said biologically active agent not forming a microsphere with said perturbant.

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