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Near-infrared noninvasive determination of pH in pulse mode

  • US 6,073,037 A
  • Filed: 08/10/1998
  • Issued: 06/06/2000
  • Est. Priority Date: 07/06/1992
  • Status: Expired due to Term
First Claim
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1. A method of determining pH in pulsatile blood in a human utilizing spectra which contains histidine information, said method comprising steps of:

  • a) generating light at three or more different wavelengths, said wavelengths being in the range of 1000 nm to 2500 nm;

    b) irradiating blood containing tissue with said wavelengths so that there is differential attenuation of at least some intensities of said wavelengths, said wavelength dependent differential attenuation being a function of said blood containing tissue, including histidine in said blood containing tissue;

    c) measuring at least a portion of said intensities of said wavelengths emerging from said blood containing tissue;

    d) using the presence of blood pulsations in said blood containing tissue and said measured intensities to obtain blood specific spectral information; and

    e) estimating said value of said blood pH from said blood specific spectral information by utilizing wavelength dependent differential attenuation derived from said histidine.

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