Peristaltic system and method for plasma separation and blood dispensation

• US 6,074,183 A
• Filed: 06/25/1998
• Issued: 06/13/2000
• Est. Priority Date: 02/09/1995
• Status: Expired due to Fees

• Current Assignee: First Medical, Inc.
• Original Assignee: First Medical, Inc.
• Inventors: Allen, Michael P., Subramanian, Kumar, Ensler, Lawrence M., Ellsworth, Stoughton L.
• Primary Examiner(s): Drodge, Joseph W.
• Application Number:
  US09/104,887
• Time in Patent Office: 719 Days
• Field of Search: 604/151, 604/153, 417/53, 417/477.1, 417/477.2, 417/477.9-477.12, 422/100, 422/102, 422/104, 436/177, 436/178, 210/416.1, 210/541, 210/542, 210/645, 210/650, 210/767, 128/214.2
• US Class Current: 417/477.2
• CPC Class Codes: B01D 35/26 Filters with built-in pumps filters provided with a pump mounted in or on the casing aquarium pumps or filters A01K63/04
• CPC Class Codes: B01D 61/14 Ultrafiltration; Microfiltration
• CPC Class Codes: B01D 61/147 Microfiltration
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

A system for separating plasma from whole blood comprises a blood separation device and a blood separation driver. The blood separation device includes a flexible tube having a needle and shield at one end and a filter member at the other end. The needle may be used to access blood in a conventional blood collection device. The separation driver applies a peristaltic force to the flexible tube of the blood separation device, thus drawing blood from the collection device through the tube and to the filter member. The driver also includes a frame having a collar and clamp mechanism for supporting the inlet end of the flexible tube, thus allowing use of the blood driver without directly exposing it to the blood. Plasma may be collected from the filter element. The present invention also provides blood dispensing systems and methods for dispensing whole and pre-filtered blood. Such blood dispensing systems comprise a blood dispensing device and a blood dispensing driver.

Claims

1. A blood dispensing driver comprising:

a frame;

a clamping assembly on the frame for removably securing a blood dispensing device comprising a flexible tube having an inlet end and an outlet end, wherein said clamping assembly comprises first and second opposed clamping elements that are translatably coupled to the frame for removably securing the flexible tube in the blood dispensing driver;

a peristaltic drive wheel mounted on the first clamping element to engage the flexible tube between the drive wheel and the second clamping element when the blood dispensing device is secured in the clamping assembly, wherein rotation of the drive wheel induces blood to flow from the inlet end to the outlet end of the flexible tube, causing blood to be dispensed;

wherein the frame comprises a collar for supporting the inlet end of the flexible tube; and

wherein the frame further comprises one or more rods which extend laterally from the collar, wherein at least one of the opposed clamping elements is translatable mounted on the rods, and wherein the dispensing driver further comprises at least one motor for translating one or both of the clamping elements to selectively secure and release the flexible tube when placed in the collar.

2. The blood dispensing driver as in claim 1, wherein the second clamping element has an arcuate surface which is aligned with the drive wheel, wherein the flexible tube is captured between the drive wheel and the arcuate surface.

3. The blood dispensing driver as in claim 1, wherein the drive wheel comprises a plurality of peripherally spaced-apart rollers.

4. A blood dispensing system comprising:

a blood dispensing device including a flexible tube having an inlet end and an outlet end and a needle structure at the inlet end of the tube;

a blood dispensing driver including a frame and a clamp mounted on the frame for removably securing the blood dispensing device, wherein said clamp comprises first and second opposed clamping elements, wherein at least one of the clamping elements is translatably coupled to the frame for translating said clamping element to selectively secure the blood dispensing device, and a peristaltic drive wheel on the frame which engages an exterior surface of the flexible tube to pass blood through a lumen thereof when the tube is secured in the clamp;

wherein the frame comprises a collar for supporting the flexible tube, and

wherein the frame further comprises one or more rods, which extend laterally from the collar, wherein at least one of the clamping elements is translatable mounted on the rods, and wherein the blood dispensing driver further comprises at least one motor for translating one or both of the clamping elements to selectively secure and release the flexible tube when placed in the collar.

5. The blood dispensing system as in claim 4, wherein the flexible tube has a length between the inlet end and the outlet end in the range from 10 mm to 100 mm and a blood flow lumen having a diameter in the range from 0.5 mm to 5 mm.

6. The blood dispensing system as in claim 4, wherein the needle structure has an axial passage which is aligned with the blood flow lumen of the flexible tube.

7. The blood dispensing system as in claim 4, wherein the blood dispensing device further comprises a receptacle shield which is attached to the inlet end of the flexible tube and which surrounds the needle structure.

8. The blood dispensing system as in claim 7, wherein the shield has a length in the range from 20 mm to 70 mm and an internal diameter in the range from 15 mm to 30 mm.

9. The blood dispensing system as in claim 4, wherein the collar is arranged for supporting the inlet end of the flexible tube.

10. The blood dispensing system as in claim 4, wherein the drive wheel is mounted on the first clamping element and the second clamping element has an arcuate surface which is aligned with the drive wheel, wherein the flexible tube is captured between the drive wheel and the arcuate surface.

11. The blood dispensing system as in claim 4, wherein the drive wheel comprises a plurality of peripherally spaced-apart rollers.

12. A blood dispensing system comprising:

a blood dispensing device including a flexible tube having an inlet end and an outlet end, wherein the inlet end of the tube has a needle structure; and

a blood dispensing driver including;

a frame, wherein the frame comprises a collar for supporting the inlet end of the flexible tube and one or more rods which extend laterally from the collar;

a clamp for removably securing the blood dispensing device, wherein said clamp comprises first and second opposed clamping elements at least one of which is translatably mounted on the rods;

a peristaltic drive wheel which is mounted on at least one of the clamping elements and engages an exterior surface of the flexible tube to pass blood through a lumen thereof when the tube is secured in the clamp; and

at least one motor for translating one or both of the clamping elements to selectively secure and release the flexible tube when placed in the collar.

13. The blood dispensing system as in claim 12, wherein one of the clamping elements has an arcuate surface which is aligned with the drive wheel, wherein the flexible tube is captured between the drive wheel and the arcuate surface.