Reagent container for an automated analyzer

• US 6,074,615 A
• Filed: 01/28/1999
• Issued: 06/13/2000
• Est. Priority Date: 03/04/1991
• Status: Expired due to Term

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Bayer Corporation (Bayer AG)
• Inventors: Whitesel, Mary Beth, Lewis, Scott C.
• Primary Examiner(s): Le, Long V.
• Application Number:
  US09/238,309
• Time in Patent Office: 502 Days
• Field of Search: 422/63, 422/102, 422/103, 436/43, 436/807, 366/237, 366/225, 366/228, 366/213, 366/214, 206/569, 206/828, 215/393, 215/DIG. 3, 215/DIG. 8
• US Class Current: 422/547
• CPC Class Codes: B01L 2300/0854 Double walls
• CPC Class Codes: B01L 3/508 rigid containers not provided for above
• CPC Class Codes: G01N 2035/00386 using fluid heat transfer medium
• CPC Class Codes: G01N 2035/00396 where the fluid is a liquid
• CPC Class Codes: G01N 2035/00524 Mixing by agitating sample carrier
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/0441 for samples
• CPC Class Codes: G01N 2035/0443 for reagents
• CPC Class Codes: G01N 2035/0465 Loading or unloading the conveyor
• CPC Class Codes: G01N 2035/0484 Belt or chain
• CPC Class Codes: G01N 2035/0486 Gearing, cams
• CPC Class Codes: G01N 2035/1025 Fluid level sensing
• CPC Class Codes: G01N 21/76 Chemiluminescence; Bioluminescence
• CPC Class Codes: G01N 35/0098 involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation magnetic particles used in immunoassays G01N33/54326; magnetic separation in general B03C
• CPC Class Codes: G01N 35/021 having a flexible chain, e.g. "cartridge belt", conveyor for reaction cells or cuvettes
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: G01N 35/1002 Reagent dispensers
• CPC Class Codes: G01N 35/1065 Multiple transfer devices
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10S 215/01 Fins
• CPC Class Codes: Y10S 215/03 : Medical
• CPC Class Codes: Y10S 215/08 : Mixing
• CPC Class Codes: Y10T 436/11 : Automated chemical analysis
• CPC Class Codes: Y10T 436/113332 : with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 : with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/114998 : with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/119163 : with aspirator of claimed structure
• CPC Class Codes: Y10T 436/25 : including sample preparation
• CPC Class Codes: Y10T 436/2575 : Volumetric liquid transfer

Abstract

An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent aspirating and dispensing probes, a separation system for separating bound from unbound tracer or labeled reagent, a detection system and date collection/processing system. All of the sub-units of the machine are controlled by a central processing unit to coordinate the activity of all of the subunits of the analyzer. The analyzer is specificallysuited for performing heterogeneous binding assay protocols, particularly immunoassays.

Claims

1. A container for reagents, comprising:

a cylindrical body portion comprising inner and outer wall surfaces disposed substantially equidistant about a central axis and first and second open ends defined by said inner and outer wall surfaces, wherein a central axis mid-point is defined between said first and second open ends;

a floor member attached to said first open end of said cylindrical body portion, said floor member having an inner surface;

two co-planar agitating members, each attached to said inner wall surfaces of said cylindrical body portion and said floor member;

a cylindrical neck portion attached to said second open end of said cylindrical body portion; and

a skirt comprising a radial portion, extending from at least a portion of said outer wall surface of said cylindrical body portion in a direction perpendicular to said central axis, and an enclosing portion, attached to said radial portion and having walls substantially equidistant to said central axis, said enclosing portion terminating on a side of said floor member opposite said first open end of said cylindrical body portion,

wherein said two co-planar agitating members are disposed on opposite sides of said inner wall surface of said cylindrical body portion and extend, in a direction parallel to said central axis, from said floor member to a point on said inner wall surface of said cylindrical body portion between said mid-point and said second open end of said cylindrical body portion, and, in a direction perpendicular to said central axis, from said inner wall surface of said cylindrical body portion towards said central axis.

2. The container of claim 1, wherein each of said first and second open ends of said cylindrical body portion lies in a respective plane, said respective planes being mutually parallel.

3. The container of claim 2, wherein said central axis is orthogonal to each of said respective planes.

4. The container of claim 1, wherein said inner surface of said floor member is concave.

5. The container of claim 1, wherein said cylindrical neck portion comprises a threaded outer wall surface.

6. The container of claim 1, wherein said radial portion of said skirt extends from a portion of said outer wall surface of said cylindrical body portion adjacent said first open end of said cylindrical body portion.

7. The container of claim 1, wherein said radial portion of said skirt extends from a portion of said outer wall surface of said cylindrical body portion adjacent said second open end of said cylindrical body portion.

8. The container of claim 1, wherein said two co-planar agitating members are each comprised of an inner edge substantially parallel to said central axis, said inner edges being equidistant from said central axis.

9. The container of claim 1, wherein said enclosing portion is substantially cylindrical.

10. The container of claim 1,

wherein said enclosing portion further comprises first, second, third and fourth portions each having a first and second edge substantially parallel to said central axis, third edges in communication with said radial portion, and fourth edges collectively comprising a terminating edge of said enclosing portion,

wherein said first, second and third portions are substantially planar and said fourth portion is outwardly curved, and

wherein said first edge of said first portion and said second edge of said second portion are joined at a right angle, said first edge of said second portion and said second edge of said third portion are joined at a right angle, said first edge of said third portion and said second edge of said fourth portion are joined, and said first edge of said fourth portion and said second edge of said first portion are joined.