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Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

  • US 6,075,025 A
  • Filed: 03/11/1998
  • Issued: 06/13/2000
  • Est. Priority Date: 10/15/1993
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula:

  • ##STR154## or a pharmaceutically acceptable salt or solvate thereof, wherein;

    one of a, b, c and d represents N or NR9 wherein R9 is O--, --CH3 or --(CH2)n CO2 H wherein n is 1 to 3, and the remaining a, b, c and d groups represent CR22 or CR24 ;

    R22 and R24 are the same or different and each independently represents H, halo, --CF3, --OR10, --COR10, --SR10, --N(R10)2, --NO2, --OC(O)R10, --CO2 R10, --OCO2 R11, benzotriazol-1-yloxy, CN, alkynyl, alkenyl or alkyl, said alkyl or alkenyl group optionally being substituted with halo, --OR10 or --CO2 R10 ;

    R26 and R28 are the same or different and each independently represents any of the substituents of R22 and R24 ;

    R5, R6, R7 and R8 each independently represents H;

    R10 represents H, alkyl, aryl, or aralkyl;

    R11 represents alkyl or aryl;

    X represents N;

    the dotted line between carbon atoms 5 and 6 represents an optional double bond, such that when a double bond is present, A and B independently represent --R10, halo --OR11, --OCO2 R11 or --OC(O)R10, and when no double bond is present between carbon atoms 5 and 6, A and B each independently represent H2, --(OR11)2 ;

    H and halo, dihalo, alkyl and H, (alkyl)2, --H and --OC(O)R10, H and --OR10, ═

    O, aryl and H, ═

    NOR10 or --O--(CH2)p --O-- wherein p is 2, 3 or 4;

    V represents --OR30 ;

    R30 represents aralkyl, aryl, or alkyl.

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