Material to be worn on the eyeball
First Claim
1. A material to be worn on a mammalian eyeball, wherein said material has a shape of a semi-spherical surface that is compatible in shape with a mammalian eyeball, wherein said shape results from either cutting of a part of a spherical surface or cutting of a part of a spherical surface on which holes, notches, or slots are partly arranged, and wherein said material has biological and surface-physical compatibilities with ophthalmic tissues and comprises, as a main component, a substantially transparent photocured crosslinked-glycosaminoglycan obtained by allowing photoreactive groups covalently bonded to a glycosaminoglycan to crosslink with each other upon irradiation, wherein said photoreactive groups covalently bonded to the glycosaminoglycan are an acyl group of cinnamic acid or a derivative of cinnamic acid, an acyl group of 1-carboxyalkylthymine or an acyl group of 7-coumaryloxyacetic acid.
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Accused Products
Abstract
The present invention provides semi-spherical materials to be worn on the eyeball, such as contact lenses for visual acuity correction or medical treatment use, cornea protecting materials, controlled drug release contact lenses and the like, which comprise, as a main component, a glycosaminoglycan existing in the living body as an extracellular matrix component of connective tissues and satisfy various requirements such as dimentional stability, transparency, surface water wettability, tissue compatibility, oxygen permeability and the like. In other words, the material to be worn on the eyeball has a shape of semi-spherical surface compatible in shape with the mammalian eyeball and has biological and surface-physical compatibilities with ophthalmic tissues and comprises, as a main component, a substantially transparent photocured crosslinked-glycosaminoglycan obtained by allowing photoreactive groups covalently bonded to a glycosaminoglycan to crosslink mutually by photoirradiation.
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Citations
13 Claims
- 1. A material to be worn on a mammalian eyeball, wherein said material has a shape of a semi-spherical surface that is compatible in shape with a mammalian eyeball, wherein said shape results from either cutting of a part of a spherical surface or cutting of a part of a spherical surface on which holes, notches, or slots are partly arranged, and wherein said material has biological and surface-physical compatibilities with ophthalmic tissues and comprises, as a main component, a substantially transparent photocured crosslinked-glycosaminoglycan obtained by allowing photoreactive groups covalently bonded to a glycosaminoglycan to crosslink with each other upon irradiation, wherein said photoreactive groups covalently bonded to the glycosaminoglycan are an acyl group of cinnamic acid or a derivative of cinnamic acid, an acyl group of 1-carboxyalkylthymine or an acyl group of 7-coumaryloxyacetic acid.
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13. A method for manufacturing a material to be worn on a mammalian eyeball, wherein said material has a shape of a semi-spherical surface that is compatible in shape with a mammalian eyeball, wherein said shape results from either cutting of a part of a spherical surface or cutting of a part of a spherical surface on which holes, notches, or slots are partly arranged, and wherein said material has biological and surface-physical compatibilities with ophthalmic tissues,
wherein said method comprises manufacturing said material from a composition which comprises, as a main component, a substantially transparent photocured crosslinked-glycosaminoglycan obtained by allowing photoreactive groups covalently bonded to a glycosaminoglycan to crosslink with each other upon irradiation, wherein said photoreactive groups covalently bonded to the glycosaminoglycan are an acyl group of cinnamic acid or a derivative of cinnamic acid, an acyl group of 1-carboxyalkvlthymine or an acyl group of 7-coumaryloxyacetic acid.
Specification