Imaging spatially varying dynamic media with diffusing correlation waves

• US 6,076,010 A
• Filed: 06/20/1996
• Issued: 06/13/2000
• Est. Priority Date: 06/20/1996
• Status: Expired due to Term

• Current Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Original Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Inventors: Yodh, Arjun G., Boas, David A.
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): YARNELL, BRYAN KEITH
• Application Number:
  US08/666,975
• Time in Patent Office: 1,454 Days
• Field of Search: 128/664, 128/665, 128/653.1, 128/633, 356/337, 356/338, 356/446, 250/341.1, 250/358.1, 600/473, 600/476, 600/407
• US Class Current: 600/477
• CPC Class Codes: G01N 2021/479 Speckle
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

Method and system for imaging media having spatially varying dynamic properties or spatially varying optical properties. The method and system utilizes a diffuse correlation wave which is a function of the properties of the medium. The correlation is constructed from photons which create a speckle pattern which falls on a detector at a known position with respect to the source of the photons after the photons have interacted with the media.

Claims

1. A method for determining properties of a medium, said method comprising the steps of:

irradiating the medium with radiation that is capable of diffusing through the medium;

receiving at a detector position streams of photons scattered from objects within the medium as said radiation diffuses through the medium;

measuring at said detector position temporal intensity fluctuations of the photon streams; and

determining spatially varying dynamic or optical properties of the medium based on one of (a) broadening of measured power spectrums and (b) decay of temporal correlation functions of the measured temporal intensity fluctuations.

2. The method of claim 1, comprising further the step of:

producing an image of the medium from the measured power spectrums or temporal correlation functions.

3. The method of claim 1, wherein the temporal correlation functions are temporal intensity autocorrelation functions.

4. The method of claim 1, wherein said determining step comprises using a correlation diffusion equation.

5. The method of claim 4, wherein the correlation diffusion equation is based on the equation

6. The method of claim 1, wherein the step of measuring the temporal intensity fluctuations comprises the step of counting photons received by the detector as a function of time.

7. The method of claim 1, wherein the step of measuring the temporal intensity fluctuations of the photon streams comprises the step of measuring the temporal intensity fluctuations of the photon streams at a plurality of detector positions.

8. The method of claim 1, wherein the radiation is light.

9. The method of claim 1, wherein the radiation is a continuous waveform.

10. The method of claim 1, wherein the radiation is unmodulated.

11. A system for producing an image of a medium, said system comprising:

a radiation source that irradiates a medium with radiation that is capable of diffusing through the medium, wherein the radiation source sets up a diffuse wave of photons which scatter through the medium;

a detector placed at a known position with respect to the radiation source, said detector detecting streams of photons scattered from objects within the medium as said radiation diffuses through the medium;

an analyzer, coupled to the detector, that measures temporal intensity fluctuations of the photon streams received by the detector;

a processor, coupled to the analyzer, that determines spatially varying dynamic or optical properties of the medium based on one of (a) broadening of measured power spectrums and (b) decay of temporal correlation functions of the measured temporal intensity fluctuations, and produces an image of the medium from the measured power spectrums or temporal correlation functions; and

a display, coupled to said processor, for displaying said image.