Apparatus for monitoring cardiac contractility

• US 6,077,236 A
• Filed: 12/05/1996
• Issued: 06/20/2000
• Est. Priority Date: 06/07/1994
• Status: Expired due to Fees

• Current Assignee: David Cunningham
• Original Assignee: David Cunningham
• Inventors: Cunningham, David
• Primary Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/750,842
• Time in Patent Office: 1,293 Days
• Field of Search: 607/19, 607/17, 607/6, 600/513, 600/587
• US Class Current: 600/587
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6882 Anchoring means
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators

Abstract

Apparatus for monitoring cardiac contractility comprises a catheter having a tip for insertion into the ventricle of the heart muscle. At or proximate the tip is an acceleration transducer responsive to the natural, multi-directional heart acceleration to provide an acceleration signal to a signal processor. The apparatus is arranged to suppress frequencies outside the range approximately 15 Hz to approximately 100 Hz.

Claims

1. Apparatus for monitoring cardiac contractility, comprising a signal processing means and a catheter having a tip for insertion into the ventricle of the heart muscle, said catheter containing at or proximate its tip a first acceleration transducer responsive to the natural heart acceleration to provide an acceleration signal via said catheter to the signal processing means (9), characterized in that one of the signal processing means and the acceleration transducer is arranged to suppress frequencies outside the range of approximately 15 Hz to approximately 100 Hz.

2. Apparatus as claimed in claim 1, wherein the signal processing means is arranged to determine the peak of the acceleration signal.

3. Apparatus according to claim 1, characterized in that the acceleration transducer is located in the catheter with the interposition of a damping means (102) which reduces to approximately 100 Hz the upper limit of the response frequency of the acceleration transducer.

4. Apparatus according to claim 3, characterized in that the damping means (102) comprises resilient conducting material disposed between the transducer and a corresponding support.

5. Apparatus according to claim 4, in which the resilient conducting material comprises adhesives which fix the acceleration transducer to the corresponding support.

6. Apparatus according to claim 3, characterized in that the damping means (102) comprises an elastic and soft material which surrounds the acceleration transducer inside the catheter.

7. Apparatus according to claim 3, characterized in that the damping means (102) comprises a fluid which surrounds the acceleration transducer inside the catheter.

8. Apparatus as claimed in claim 1, characterized in that the acceleration transducer is responsive to acceleration in any spatial direction.

9. Apparatus as claimed in claim 8, wherein the acceleration transducer comprises three uniaxial acceleration transducers arranged with respective sensing axes on which they are sensitive perpendicular to each other, and wherein the signal processing means is arranged to determine the peak-to-peak value of the acceleration signal from each uniaxial transducer and to determine one of the modulus and the mean of the three peak-to peak signals.

10. Apparatus as claimed in claim 8, wherein the acceleration signal processing means calculates the modulus of the acceleration vector to which the sensor is subjected.

11. Apparatus as claimed in claim 10, in which the transducer (2) comprises a body of piezoelectric material in the form of a spherical casing formed by two hemispherical bodies (65-165) provided on inner and outer faces with corresponding inner and outer metal coatings, the inner metal coating being connected to an external contact (357) which forms an electrode of the transducer and which is electrically isolated from the rest of the outer metal coating which forms another electrode of the transducer, and a spherical seismic mass disposed inside the casing.

12. Apparatus according to claim 11, in which at least one layer of anti-wear material is provided between the seismic mass (69) and the inner metal coating (67-167).

13. Apparatus according to claim 11, in which the casing of the transducer (2) is housed in a terminal socket (70) of a hollow metal point (59) of the tip of the catheter, and the transducer has its isolated electrode (367) gripped and retained in situ by a forked end (71-171-72) of a flat metal chassis (73) disposed longitudinally in the point and carrying an electronic circuit (75) associated with the transducer, another end of said chassis pressing on a hollow metal plug (62) fixed within the hollow point (59), and said plug including an internal grommet (63) through which passes the electrode (8) connected to the electronic circuit, said another electrode (7) being connected to the plug.

14. Apparatus according to claim 13 in which the electronic circuit (75) comprises a buffer consisting of a MOS transistor (77) and a corresponding coupling resistor (77).

15. Apparatus according to any claim 1, including means for sampling the output of the acceleration transducer periodically to provide a sampled acceleration signal;

and wherein the signal processing means includes means for reconstructing a continuous acceleration signal from the sampled acceleration signal; and

a band pass filter having a pass band of approximately 15 Hz to approximately 100 Hz for filtering the reconstructed acceleration signal.

16. Apparatus according to claim 15, characterized by mechanical damping means (102) disposed on the acceleration transducer to limit the top of the band to approximately 100 Hz.

17. Apparatus according to claim 16 characterized in that the acceleration transducer is responsive to acceleration in any spatial direction, and wherein the signal processing means (9) comprises:

means to send current pulses to activate the acceleration transducer (2), said pulses having a duration of approximately 30 microseconds at intervals of approximately 3000 microseconds; and

means (47) for determining the peak-to-peak values of the filtered signal and for processing the filtered signal to calculate the value of cardiac contractility in successive heart cycles.

18. Apparatus as claimed in claim 17, including means for detecting, for determining the end of each heart cycle, any of a ventricular electrical stimulus, a QRS wave, an electric defibrillation shock, and a programmed time interval of the order of approximately 5 seconds.

19. Apparatus according to claim 17, wherein the acceleration transducer comprises three uniaxial acceleration transducers and including a chassis (61) fixed inside a hollow metal point (59) of the tip of the catheter, the chassis including a section having at least two longitudinal walls (161-261) perpendicular to each other and an end wall (361) perpendicular to the two walls, the uniaxial acceleration transducers being fitted on respective said walls with the interposition of the damping means (102), the chassis being provided with a flat terminal section (461) disposed coaxially in the hollow point of the catheter and having a forked end pressing on a metal plug (62) fixed within the point, the metal plug carrying a grommet (63) through which passes an electrode (8) which is connected to an electronic circuit (64) associated with the acceleration transducers and fixed to the flat terminal section of the chassis (61), and another electrode (7) being electrically connected to the metal plug.

20. Apparatus according to claim 12 in which the acceleration transducer (2) comprises three uniaxial acceleration transducers (2x-2y-2z) arranged with the respective sensing axes on which they are sensitive perpendicular to each other, the transducers having respective buffers (11-111-211) connected through corresponding transducer switches (4x-4y-4z) to an input of an output buffer (5), a timing circuit (10) controlling the switches so that the signals produced by the three acceleration transducers are available in separate and successive time intervals, and said output buffer providing a supply voltage for said timing circuit.

21. Apparatus as claimed in claim 20, wherein one of the sensing axes is aligned with the axis of the tip (1) of the catheter.

22. Apparatus according to claim 20, in which means are provided to activate the timing circuit (10) when it receives from the signal processing means (9) a pulse (14) of the order of a few tens of microamperes, maintained for a total time interval (T) of the order of approximately a hundred microseconds.

23. Apparatus according to claim 20, in which the timing circuit (10) comprises a counter (15-16) having outputs (17-18-19) to control the transducer switches (4x-4y-4z), means (32) for resetting the counter on arrival of an activation signal (14) from the signal processing means (9), the timing circuit including clock means (20-21-22-23-24-25-26-27-28-29) for applying to the counter a switching clock pulse of approximately 30 microseconds, and means (29-30) to de-activate or disable said clock means when the counter reaches a predetermined count.

24. Apparatus according to claim 20, in which the input to the output buffer (5) is connectable through a load switch (34) to a load (33), the timing circuit (110) comprising a counter (15-16) having outputs which control said transducer switches and said load switch so that operation of said load switch produces a distinctive end-of-reading voltage signal at the output of the output buffer (5), the signal processing means (9) being responsive to said end-of-reading signal to interrupt the supply to the whole circuit located in the catheter.

25. Apparatus according to claim 24 wherein the signal processing means is responsive to said end-of-reading signal for generating a voltage which saturates a current generator supplying current to said circuit.

26. Apparatus according to claim 24, characterized in that the timing circuit (110) associates an end-of-reading state with each said separate and successive time interval means being provided in the signal processing means (9) to make the unit read the individual transducers in real time.

27. Apparatus according to claim 24, characterized in that the timing circuit (310) is responsive to a pulse train (40) from the signal processing means (9) to sequentially trigger the transducer switches (4x-4y-4z) and the load switch (34), said pulse train having a cyclic repetition every 3000 microseconds, and each pulse of the train lasting for approximately 30 microseconds and being separated from the next pulse by approximately 30 microseconds;

the timing circuit (310) including means (36,37) responsive to the counter reaching a full count to reset the counter after a time delay (31) of the order of a microsecond, and a capacitor (38) supplying power to the counter for keeping the counter active for at least 30 microseconds.

28. Apparatus according to claim 20, characterized in that the signal processing means (9) provides successive trains of current pulses at cyclic intervals and in which each pulse in the train is separated from the next pulse, the timing circuit comprising a counter (15-16) arranged to count the pulses in said pulse trains, and having four outputs (17-18-19-35), in which the first three outputs control the switches of the acceleration transducers (2x-2y-2z) and the fourth output (35) is connected through a delay line (37) and a logic circuit (36 to reset the counter, resetting of the counter also being provided through a suitable time constant (31) at the start of the cycle, a capacitor (38) providing power to the timing circuit to keep the counter active between pulses in the trains, and the capacitor being included within an electrical circuit providing a rate of discharge of the capacitor such that the capacitor is discharged in a time interval less than that between the pulse trains (40) from the signal processing means.

29. Apparatus according to claim 20, characterized in that the signal processing means (9) includes means (44-144-244) to reconstruct continuous acceleration signals relating to the three acceleration transducers (2x-2y-2z), and pass-band filters (46-146-246) to filter the reconstructed signals, in the pass band of approximately 15-100 Hz, the three signals thus obtained being processed by means (47) which determine their peak-to-peak value and then determines one of the modulus and the mean of the three peak-to-peak values.