Delivery of a composition to the lung
First Claim
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1. A method for delivering a composition to a lung, said method comprising the steps of:
- (a) inserting a pulmonary artery catheter into a pulmonary artery supplying said lung via a first non-surgical percutaneous route, wherein said pulmonary artery catheter comprises a deployable means for occluding said inserted pulmonary artery;
(b) inserting a pulmonary vein catheter into a pulmonary vein draining said lung via a second non-surgical percutaneous route, wherein said pulmonary vein catheter comprises a deployable means for occluding said inserted pulmonary vein; and
(c) delivering said composition to said lung via at least one of the group consisting of said pulmonary artery catheter and said pulmonary vein catheter.
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Abstract
In general, the invention features methods for delivering a composition to the lung in a non-surgical, percutaneous approach by utilizing the pulmonary vasculature (i.e., the pulmonary arteries and veins).
Also disclosed are methods allowing for the lung-specific delivery of a composition, as well as a catheter that includes a deployable arm.
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Citations
41 Claims
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1. A method for delivering a composition to a lung, said method comprising the steps of:
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(a) inserting a pulmonary artery catheter into a pulmonary artery supplying said lung via a first non-surgical percutaneous route, wherein said pulmonary artery catheter comprises a deployable means for occluding said inserted pulmonary artery; (b) inserting a pulmonary vein catheter into a pulmonary vein draining said lung via a second non-surgical percutaneous route, wherein said pulmonary vein catheter comprises a deployable means for occluding said inserted pulmonary vein; and (c) delivering said composition to said lung via at least one of the group consisting of said pulmonary artery catheter and said pulmonary vein catheter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for delivering a drug to a lung comprising more than one pulmonary vein, said method comprising the steps of:
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(a) inserting a pulmonary vein catheter into a pulmonary vein of said lung via a non-surgical percutaneous route, wherein said pulmonary vein catheter comprises (i) a deployable means for occluding the pulmonary vein into which it has been inserted, and (ii) a number of deployable arms that is equal to the number of pulmonary veins of said lung minus one; (b) inserting each of said deployable arms into a different pulmonary vein of said lung, wherein the pulmonary vein into which a deployable arm is inserted does not contain said pulmonary vein catheter; and (b) delivering said drug to said lung via said pulmonary vein catheter and said deployable arms. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for delivering a drug to a lung comprising more than one pulmonary vein, said method comprising the steps of:
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(a) inserting a pulmonary vein catheter into each pulmonary vein of said lung via a non-surgical percutaneous route, wherein each pulmonary vein catheter comprises a deployable means for occluding the pulmonary vein into which it has been inserted and not more than one catheter is inserted into a single pulmonary vein; and (b) delivering said drug to said lung via the pulmonary vein catheters. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41)
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Specification