Gastric acid binding chewing pastilles

• US 6,077,524 A
• Filed: 05/16/1997
• Issued: 06/20/2000
• Est. Priority Date: 05/06/1994
• Status: Expired due to Term

• Current Assignee: Bolder Arzneimittel GmbH
• Original Assignee: Bolder Arzneimittel GmbH
• Inventors: Imer, Faruk, Bolder, Hermann-Josef
• Primary Examiner(s): Kulkosky, Peter F.
• Application Number:
  US08/737,280
• Time in Patent Office: 1,131 Days
• Field of Search: 424/434, 424/440, 424/441, 426/573, 426/3, 426/74
• US Class Current: 424/441
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 33/10 Carbonates; Bicarbonates
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system

Abstract

The subject matter of the invention is chewing pastilles based on at least partially or complete water soluble natural and/or synthetic polymers, selected from gums, alginates, carrageen, starch, pectin, and gelatin, which will form gels or viscous solutions in aqueous system, and additional adjuvants and additives, said pastilles containing antacids as active ingredients.

Claims

1. Gum pastilles prepared by dissolving in water at least partially or completely water soluble natural and/or synthetic polymers selected from the group consisting of gums, alginates, carrageen, starch, and pectin, which polymers are hydrocolloids and form gels or viscous solutions in aqueous systems, and additional adjuvants and additives, and dissolving, emulsifying, or suspending antacids into the resulting solution such that said antacids are homogeneously distributed in the pastille, said antacids having an acid binding capacity of from 10 to 40 mval per unit dose wherein the pastilles comprise from 2 to 80% by weight of the polymers based on the total mass of the pastilles.

2. The pastilles according to claim 1 wherein the chewing pastilles are based on at least gums selected from gum arabic or tragacanth.

3. The pastilles according to claim 1 wherein the adjuvants and additives are selected from the group consisting of sugar, sugar substitutes, hydrogenated fats, stearic acid, paraffins, oligosaccharides, polysaccharides, dextran, and mixtures thereof.

4. The pastilles according to claim 3 comprising sugar substitutes selected from the group consisting of fructose, sorbitol, mannitol, xylitol, hydrogenated glucose syrup, artificial sweeteners, and mixtures thereof.

5. The pastilles according to claim 2 wherein the pastilles comprise from 10 to 60% by weight of gum arabic based on the total mass of the pastilles.

6. The pastilles according to claim 4 wherein the pastilles comprise from 20 to 50% by weight of sugar substitutes based on the total mass of the pastilles.

7. The pastilles according to claim 1 wherein the antacids have an acid binding capacity from 10 to 25 mval per unit dose.

8. The pastilles according to claim 1 wherein the antacids are selected from the group consisting of aluminum hydroxides, aluminum phosphates, magnesium hydroxide, magnesium oxide, magnesium carbonate, magnesium silicate, magnesium aluminum silicates, hydrotalcite and magaldrate, sodium carbonate, calcium carbonate, and mixtures thereof.