Estradiol and progesterone-based medicament

• US 6,077,531 A
• Filed: 09/28/1998
• Issued: 06/20/2000
• Est. Priority Date: 04/05/1996
• Status: Expired due to Term

• Current Assignee: Laboratories Besins Iscovesco
• Original Assignee: Laboratories Besins Iscovesco
• Inventors: Salin-Drouin, Dominique
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): WARE, TODD
• Application Number:
  US09/155,331
• Time in Patent Office: 631 Days
• Field of Search: 514/177, 514/182, 424/489, 424/451, 424/455, 424/457
• US Class Current: 424/451
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 9/4808 characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release capsules filled with granules or microparticles A61K9/16; filled with microcapsules or coated microparticles A61K9/50; with mixture of different granules, microcapsules, (coated) microparticles A61K9/5084

Abstract

A medicament consisting of a biological medium-soluble capsule containing a micronised progesterone suspended in oil is disclosed, characterised in that the capsule also contains estradiol enclosed in microspheres, also suspended in oil, and which consist of one or more polymers that do not dissolve in oil but that dissolve in a biological medium.

Claims

1. Medicament constituted by a capsule soluble in a biological medium, containing a progesterone in the micronized state in suspension in oil, wherein the capsule also contains estradiol enclosed in microspheres also in suspension in the oil and which are constituted by at least one polymer adapted not to dissolve in the oil but to dissolve in a biological medium.

2. Medicament according to claim 1, wherein said polymer is a hydroxypropylcellulose polymer.

3. Medicament according to claim 1, wherein said polymer is a polymethacrylate polymer.

4. Medicament according to claim 1, characterized in that the polymer is a polyvinyl pyrrolidone.

5. Medicament according to claim 1 wherein the oil is peanut oil.