Controlled release tablet compositions

• US 6,077,538 A
• Filed: 06/15/1999
• Issued: 06/20/2000
• Est. Priority Date: 02/28/1997
• Status: Expired due to Term

• Current Assignee: Encinal Pharmaceutical Investments, LLC
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Hwang, Paul M., Ayer, Atul D., Kuczynski, Anthony L., Merrill, Sonya, Johnson, Deborah J., Ahlgren, Nils W.
• Primary Examiner(s): Jarvis, William R. A.
• Application Number:
  US09/333,380
• Time in Patent Office: 371 Days
• Field of Search: 424/470, 424/464, 424/468
• US Class Current: 424/470
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/2009 Inorganic compounds
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/2031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

An opiate analgesic composition and a non-opiate analgesic composition are disclosed for delivering an analgesic in either embodiment to a patient in need of relief from pain. The analgesics are present optionally with a nonionic surfactant and with an osmotic composition comprising a carbonate or bicarbonate for delivering the opiate analgesic and non-opiate analgesic from a dosage form.

Claims

1. A tablet composition comprising 111 mg of sodium carboxymethylcellulose, 57 mg of sodium bicarbonate, 10 mg of hydroxypropylmethylcellulose, 10 mg of hydroxypropylcellulose and 0.5 mg of magnesium stearate.

2. A tablet comprising 63.67% poly(ethylene oxide) of 7,000,000 molecular weight, 30 wt % sodium bicarbonate, 5 wt % hydroxypropylmethylcellulose of 11,200 molecular weight, 1 wt % ferric oxide, 0.25 wt % magnesium stearate and 0.08 wt % butylated hydroxytoluene.