Gelatin spray coating

• US 6,077,540 A
• Filed: 08/08/1997
• Issued: 06/20/2000
• Est. Priority Date: 08/08/1997
• Status: Expired due to Term

• Current Assignee: Bayer Corporation (Bayer AG)
• Original Assignee: Bayer Corporation (Bayer AG)
• Inventors: Lonesky, Steven M., Callahan, Thomas P., Daher, Lawrence J.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Seidleck, Brian K.
• Application Number:
  US08/908,703
• Time in Patent Office: 1,047 Days
• Field of Search: 424/45, 424/456, 424/460, 424/463, 424/474, 424/475, 424/466, 424/478, 424/464, 424/465
• US Class Current: 424/478
• CPC Class Codes: A61K 9/282 Organic compounds, e.g. fats
• CPC Class Codes: A61K 9/2873 Proteins, e.g. gelatin
• CPC Class Codes: A61K 9/2886 having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer of the type active core-drug layer-inactive layer A61K9/209

Abstract

This invention provides a coating composition in which the principal film former is gelatin for use in coating tablets. The gelatin coating may be used with tablets, with or without any subcoating, and may be applied using conventional equipment. For a subcoated tablet, the coating formulation contains gelatin, a surfactant and a drying agent.

Claims

1. A tablet comprising:

a. a subcoated tablet core containing active medicinal or nutritional ingredients; and

b. a continuous gelatin coating on the subcoated tablet core which coating is composed of gelatin, a surfactant; and

a drying agent wherein the drying agent is selected from the group consisting of sodium sulfate, magnesium sulfate and potassium sulfate.

2. A tablet comprising:

a. a raw tablet core containing active medicinal or nutritional ingredients; and

b. a continuous gelatin coating on the tablet core which coating is composed of gelatin, a surfactant, a drying agent and a plasticizer wherein the drying agent is selected from the group consisting of sodium sulfate, magnesium sulfate and potassium sulfate.

3. A tablet coating composition comprising:

a. gelatin;

b. a surfactant; and

c. a drying agent wherein the drying agent is selected from the group consisting of sodium sulfate, magnesium sulfate and potassium sulfate.

4. The coating composition of claim 3 in which the gelatin is selected from the group consisting of fish gelatin and mammalian gelatin.

5. The coating composition of claim 4 in which the gelatin is fish gelatin.

6. The coating composition of claim 3 in which the surfactant is a protein complexing surfactant.

7. The coating composition of claim 6 in which the protein complexing surfactant is selected from the group consisting of sodium stearoyl lactylate, calcium stearoyl lactylate and glyceryl monostearate.

8. The coating composition of claim 7 in which the protein complexing surfactant is sodium stearoyl lactylate.

9. The coating composition of claim 3 in which the drying agent is sodium sulfate.

10. The coating composition of claim 3 which additionally includes a plasticizer.

11. The coating composition of claim 10 in which the plasticizer is selected from the group consisting of propylene glycol monostearate and sodium lactate.

12. The coating composition of claim 11 in which the plasticizer is propylene glycol monostearate.

13. The coating composition of claim 10 which additionally includes a leveling agent.

14. A coating composition comprising:

a. from about 5 to about 25% by weight of gelatin;

b. a surfactant;

c. a drying agent selected from the group consisting of sodium sulfate, magnesium sulfate and potassium sulfate;

d. a plasticizer;

e. a leveling agent; and

f. water.

15. The coating composition of claim 14, which is comprised of

a. from about 8 to 12% by weight of gelatin;

b. a surfactant selected from the group consisting of sodium stearoyl lactylate, calcium stearoyl lactylate and glyceryl monostearate;

c. a drying agent selected from the group consisting of sodium sulfate, magnesium sulfate and potassium sulfate;

d. a plasticizer selected from the group consisting of a propylene glycol monostearate and sodium lactate;

e. a leveling agent; and

f. water.

16. The coating composition of claim 15 which additionally includes sodium lactate and sodium acetate.

17. A method of film coating a tablet core, comprising:

a. spray coating a tablet core with a coating composition containing gelatin, a surfactant, and a drying agent; and

b. drying the gelatin coated tablet cores wherein the drying agent is selected from the group consisting of sodium sulfate, magnesium sulfate and potassium sulfate.

18. A method of coating a tablet core, comprising the steps of:

a) forming a water based composition by mixing water, gelatin, a surfactant and a drying agent; and

b) spraying and drying the water based coating composition on a tablet core to form a continuous coating using equipment wherein the drying agent is selected from the group consisting of sodium sulfate, magnesium sulfate and potassium sulfate.

19. The method of claim 18 in which the water based coating composition is adjusted to a basic pH prior to spraying.