Self referencing photosensor

• US 6,078,833 A
• Filed: 03/25/1998
• Issued: 06/20/2000
• Est. Priority Date: 03/25/1998
• Status: Expired due to Term

• Current Assignee: ISS
• Original Assignee: ISS
• Inventors: Hueber, Dennis M.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US09/047,964
• Time in Patent Office: 818 Days
• Field of Search: 600/407, 600/473, 600/476, 600/310, 600/316, 600/322, 600/323, 356/39-41, 356/341
• US Class Current: 600/476
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A method and apparatus for determining parameters of a medium, preferably a highly scattering medium such as living tissue. At least two spaced light sources provide light through the tissue or other medium to at least two spaced detectors, with the spacing between the light sources and the detectors being constrained to certain dimensions. The combined data received by such detectors can provide data that is substantially independent of the intensity of the light sources, the sensitivity of the detectors, the coupling efficiency of light from the light sources into the medium, and the coupling efficiency of light from the medium to the detectors. The light from the two sources is of substantially identical wavelength.

Claims

1. The method of determining parameters of a medium which comprises the steps of:

passing a first portion of light from a first light source through said medium to a first detector, and passing a second portion of light from said first light source through said medium to a second detector;

passing a third portion of light from a second light source through said medium to the second detector, the distance between said first light source and said first detector and the second light source and said second detector being substantially equal, and passing a fourth portion of light from said second light source through said medium to said first detector, the distance between said first light source and the second detector and the second light source and said first detector being substantially equal; and

combining data received by said detectors in a manner that is substantially independent of;

intensity of the light sources, sensitivity of the detectors, coupling efficiency of light from the light sources into said medium, and coupling efficiency of light from said medium to said detectors; and

determining a parameter of said medium from said data, said light portions being of substantially identical wavelength.

2. The method of claim 1 in which data received by said detectors comprises the intensities of said light portions as a function of distances between detectors and light sources.

3. The method of claim 1 in which said method is repeated, sequentially using single members of a plurality of first light sources and a plurality of second light sources for improved data accuracy.

4. The method of claim 1 further comprising the step of respectively passing fifth and sixth portions of light from a third light source to said first and second detectors, said third light source being equidistantly positioned from said first and second detectors, to provide a reference light source for self-calibration of the detectors.

5. The method of claim 4 in which said method is repeated, sequentially using single members of a plurality of said third light sources for improved self-calibration accuracy.

6. The method of claim 1 in which said first and second detectors are parts of a single array detector.

7. The method of determining parameters of a highly scattering medium, which comprises the steps of sequentially:

passing a first modulated portion of light from a first light source through said highly scattering medium to a first detector, and passing a second modulated portion of light from said first light source through said highly scattering medium to a second detector;

passing a third modulated portion of light from a second light source through said highly scattering medium to said second detector, the distance between said first light source and said first detector and the second light source and said second detector being substantially equal, and passing a fourth modulated portion of light from said second light source through said highly scattering medium to said first detector, the distance between said first light source and the second detector and the second light source and said first detector being substantially equal;

said modulated portions of light being of substantially the same wavelength and each being modulated at the same frequency, said first and second light detectors being modulated at a second frequency that is different from said first frequency; and

determining data points comprising a combination of data from said first and second detectors and determining a parameter of said medium from said data points.

8. The method of claim 7 in which said combined data is indicative of at least two of phase, AC, and DC components of signals from said detectors.

9. The method of claim 7 in which the parameter determined comprises at least one of an absorption coefficient, an index of refraction, and a scattering coefficient of said medium.

10. The method of claim 9 comprising the step of determining rate of change by distance in at least two of phase shift, ln DC, and ln AC components detected from the resultant signals derived from said light beams, and determining at least one of said absorption coefficient, index of refraction, and scattering coefficient of said medium from said rates of change.

11. The method of claim 10 comprising the step of determining an absolute concentration in said medium of at least one form of hemoglobin from said absorption coefficient, using said method twice with two different wavelengths of light.

12. The method of claim 11, comprising the step of determining the ratio of two forms of hemoglobin in a tissue.

13. The method of claim 10 comprising the step of determining a relative concentration of glucose in said medium from said scattering coefficient, multiplied by the index of refraction.

14. The method of claim 7 in which the step of determining the parameter of said medium from said data comprises the steps of combining the respective data received from the first and second detectors in a manner that is substantially independent of:

intensity of the light sources, sensitivity of the first and second sensors, high frequency phase response of the light sources and sensors, coupling efficiency of light passing from the light sources to the highly scattering medium, and coupling efficiency of light passing from the highly scattering medium to the detectors, whereby calibration of the light sources and sensors is rendered unnecessary.

15. The method of claim 7 in which said method is repeated, sequentially using single members of a plurality of first light sources and sequentially using a plurality of second light sources for improved data accuracy.

16. The method of claim 7 further comprising the step of respectively passing fifth and sixth portions of light from a third light source to said first and second detectors, said third light source being equidistantly positioned from said first and second detectors, to provide a reference light source for self-calibration of the detectors.

17. The method of claim 16 in which said method is repeated, sequentially using single members of a plurality of said third light sources for improved self-calibration accuracy.

18. The method of claim 7 in which said first and second detectors are parts of a single array detector.

19. A self-referencing photosensor which comprises a probe having a face for contact with a medium for testing with a photosensing technique;

a controller electrically connected to said probe for receiving signals from said probe;

and a computer for receiving and processing signals from said controller responsive to the signals from said probe, and for converting said signals into data;

said probe having spaced first and second light sources positioned to emit light of substantially identical wavelength through apertures of said face, said probe also having spaced first and second detectors positioned to receive light from said medium passing through other apertures of said face;

said first light source having a spacing from said first detector which is equal to the spacing between said second light source and said second detector, said first light source having a spacing from said second detector which is equal to the spacing between said second light source and said first detector.

20. The self-referencing photosensor of claim 19 in which the face of said probe is adapted to be in contact with living tissue.

21. The self-referencing photosensor of claim 20 in which a plurality of said first light sources and a plurality of said second light sources are present.

22. The self-referencing photosensor of claim 19 in which a third light source is present to pass light through a third aperture in said face, said third light source being equidistantly positioned between said first and second detectors to provide a reference light source for self-calibration of the detectors.