Pseudospontaneous neural stimulation system and method

• US 6,078,838 A
• Filed: 02/13/1998
• Issued: 06/20/2000
• Est. Priority Date: 02/13/1998
• Status: Expired due to Term

• Current Assignee: University of Iowa Research Foundation
• Original Assignee: University of Iowa Research Foundation
• Inventors: Rubinstein, Jay
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/023,278
• Time in Patent Office: 858 Days
• Field of Search: 607/55-57, 607/137, 623/10, 600/25
• US Class Current: 607/55
• CPC Class Codes: H04R 25/502 using analog signal processing
• CPC Class Codes: H04R 25/75 Electric tinnitus maskers providing an auditory perception

Abstract

A signal processing apparatus and method for neural stimulation is provided that can generate stochastic independent activity across an excited nerve or neural population. High rate pulse trains, for example, can produce random spike patterns in auditory nerve fibers that are statistically similar to those produced by spontaneous activity in the normal ear. This activity is called "pseudospontaneous activity". Varying rates of pseudospontaneous activity can be created by varying the intensity of a fixed amplitude, high rate pulse train stimulus, e.g., 5000 pps. The pseudospontaneous activity can eliminate a major difference between acoustic- and electrical-derived hearing percepts. The pseudospontaneous activity can further desynchronize the nerve fiber population as a treatment for tinnitus.

Claims

1. A method for generating pseudospontaneous activity in an auditory nerve, comprising:

generating a pseudospontaneous driving electrical signal; and

applying the pseudospontaneous driving electrical signal to the auditory nerve to generate pseudospontaneous activity in the auditory nerve.

2. The method of claim 1, wherein the pseudospontaneous driving electrical signal includes a high rate pulse train, and wherein the applying step generates substantially continuous pseudospontaneous activity.

3. The method of claim 1, wherein the pseudospontaneous driving electrical signal includes a broadband noise.

4. The method of claim 1, wherein the pseudospontaneous driving electrical signal includes at least fluctuations in amplitude greater than a prescribed amount at a frequency above approximately 2 kHz.

5. The method of claim 1, wherein the applying step comprises applying current to the auditory nerve, wherein the auditory nerve comprises a plurality of nerve fibers, and wherein the pseudospontaneous activity is demonstrated by statistically independent activity in the plurality of nerve fibers.

6. The method of claim 1, wherein the applying step further comprises effectively suppressing tinnitus in a patient.

7. The method of claim 1, wherein the applying step is performed by one of a middle ear implant and an inner ear implant, and wherein the generating step is performed by a signal generator.

8. The method of claim 1, wherein the auditory nerve comprises a plurality of nerve fibers, and wherein the pseudospontaneous driving electrical signal comprises one or more signals that generate a substantially maximum firing rate of the plurality of neurons.

9. A neural prosthetic apparatus for treatment of a patient with tinnitus, comprising:

a stimulation device that outputs one or more electrical signals that include transitions between first and second amplitudes occurring at a frequency greater than approximately 2 kHz;

an arrangement of at least one electrical contact adapted to be affixed within the cochlea of the patient; and

electrical coupling means for electrically coupling the at least one electrical contact to the stimulation device, and wherein the neural prosthetic apparatus effectively alleviates the tinnitus of the patient.

10. The apparatus according to claim 9, wherein the electrical signals include a high rate pulse train.

11. The apparatus according to claim 9, wherein the electrical signals cause pseudospontaneous activity in an auditory nerve.

12. The apparatus according to claim 9, wherein the neural prosthetics apparatus is at least one of an inner ear implant and a middle ear implant.

13. The apparatus according to claim 9, wherein the first and second amplitudes are positive and negative, respectively, and wherein the first and second amplitudes are equal in magnitude.

14. A method for treating a patient with tinnitus, comprising:

outputting one or more pseudospontaneous driving signals; and

delivering the one or more pseudospontaneous driving signals to an auditory nerve, wherein the one or more pseudospontaneous driving signals generate pseudospontaneous activity to effectively alleviate the tinnitus of the patient.

15. The method according to claim 14, wherein the one or more pseudospontaneous driving signals includes a high rate pulse train having a frequency above 2 kHz.

16. A neural prosthetic apparatus for treatment of a patient with tinnitus, comprising:

a pseudospontaneous signal generator that generates an electrical signal;

an arrangement of at least one electrical contact adapted to be affixed in the middle ear of the patient; and

a stimulation device coupled to the generator that applies the electrical signal to the at least one electrical contact, the electrical signal capable of generating pseudospontaneous activity in the auditory nerve, and wherein the neural prosthetic apparatus effectively alleviates the tinnitus of the patient.

17. The apparatus of claim 16, wherein the electrical signal transitions between first and second amplitudes at a frequency above 2 kHz.

18. The apparatus of claim 16, wherein the electrical contact is adapted to be affixed nearby a round window of the patient.

19. The apparatus of claim 18, wherein the electrical contact is adapted to be electrically coupled to the auditory nerve.

20. The apparatus of claim 16, wherein the electrical contact is adapted to be affixed nearby the cochlea of the patient.

21. An apparatus that generates pseudospontaneous activity in at least one auditory nerve, comprising:

a device that generates a pseudospontaneous driving signal; and

a stimulation device coupled to the device, the stimulation device capable of delivering the pseudospontaneous driving signal to the at least one auditory nerve, wherein the pseudospontaneous driving signal induces pseudospontaneous activity in the at least one auditory nerve.

22. The apparatus of claim 21, wherein the device is one of a circuit, a resonating circuit and a signal generator.

23. The apparatus of claim 21, wherein the pseudospontaneous driving signal includes at least fluctuations in amplitude greater than a prescribed amount at a frequency above approximately 2 kHz.