Catheter system for delivery of aerosolized medicine for use with pressurized propellant canister

• US 6,079,413 A
• Filed: 12/20/1996
• Issued: 06/27/2000
• Est. Priority Date: 06/17/1994
• Status: Expired due to Term

• Current Assignee: Trudell Medical Limited
• Original Assignee: Trudell Medical Limited
• Inventors: Baran, George
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): WEISS JR, JOSEPH
• Application Number:
  US08/770,262
• Time in Patent Office: 1,285 Days
• Field of Search: 128/200.18, 128/200.21, 128/205.11, 128/203.12, 128/200.23, 128/200.26, 128/207.14, 128/207.15, 604/284
• US Class Current: 128/207.14
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 16/0404 with means for selective or partial lung respiration
• CPC Class Codes: A61M 16/0463 combined with suction tubes, catheters or the like; Outside connections
• CPC Class Codes: A61M 16/0484 at the distal end
• CPC Class Codes: A61M 16/0486 Multi-lumen tracheal tubes
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 25/0111 Aseptic insertion devices

Abstract

An improved system for delivery of an aerosolized medicine to a patient'"'"'s respiratory system. The system uses a pressurized canister that contains a mixture of a medicine and a propellant which may be in a liquid state. The canister has an outlet from which the mixture can exit. The system includes an extension catheter that connects at a proximal end to the outlet of the canister. The extension catheter has a length such that a distal end can be positioned either in an endotracheal tube or deep in the respiratory tract of the patient while the proximal end of the extension catheter is connected to the canister which is located outside the patient'"'"'s body. The extension catheter includes at least one lumen extending therethrough for conveying the medicine and liquid propellant mixture from the canister to a distal exit orifice where an aerosol can be generated as the propellant evaporates. The aerosolized medicine is carried by the patient'"'"'s inhalation and delivered to the lungs. The extension catheter may be positioned in an endotracheal tube or alternatively may be used with a patient who is not intubated.

Claims

1. An improved system for the delivery of an aerosolized medical agent to a patient'"'"'s respiratory system comprising:

a pressurized canister that contains a mixture of fine particles of a medical agent and a propellant in a liquid state and further that has an outlet from which the medicine and liquid propellant can exit the canister;

an endotracheal tube having a ventilation lumen for ventilating the patient and a secondary lumen that terminates distally in a distal opening that communicates with said main lumen;

an extension catheter having a proximal end and a distal end and a lumen extending from the proximal end to a distal orifice located at said distal end, said extension catheter located in said secondary lumen of said endotracheal tube, and extending distally of a distal end of said distal opening so that a distal portion of said extension catheter extends into said ventilation lumen of said endotracheal tube; and

a connection between said proximal end of said extension catheter and said outlet of said pressurized canister to provide a fluid connection between said canister and said lumen of said extension catheter to permit medicine and propellant to be conveyed from said canister through said lumen of said extension catheter and out said distal orifice of said extension catheter where the propellant evaporates and an aerosol of the medical agent is generated.

2. The system of claim 1 further comprising:

a centering device associated with said distal portion of said extension catheter to align said distal portion of said extension catheter with respect to said ventilation lumen of said endotracheal tube.

3. The system of claim 2 further comprising:

a second centering device associated with said distal portion of said extension catheter to align said distal end of said extension catheter with respect the patient'"'"'s air flow passage.

4. The system of claim 1 in which said extension catheter is removable with respect to said endotracheal tube.

5. The system of claim 1 in which said extension catheter is non-removable with respect to said endotracheal tube.

6. The system of claim 1 in which said distal portion of said extension catheter also extends distally of a distal end of said endotracheal tube.

7. The system of claim 1 in which said distal portion of said extension catheter aligns with a distal end of said endotracheal tube.

8. The improved system of claim 1 in which said extension catheter has a plurality of distal orifices located at the distal end.

9. An apparatus for the delivery to a patient'"'"'s respiratory tract of an aerosolized medicine from a canister that contains a mixture of a medicine and a pressurizing propellant, comprising:

a catheter having a proximal end and a distal end;

the distal end positionable in an air flow passage in the patient'"'"'s respiratory tract, the proximal end adapted to connect to a canister to permit the mixture from the canister to be transmitted into a lumen of the catheter; and

the catheter having a distal orifice communicating with the lumen, the distal orifice oriented to expel the mixture in a reverse direction back towards the proximal end.

10. A system for the delivery to a patient'"'"'s respiratory tract of an aerosolized medicine from a pressurized canister containing a medicine and a propellant and that generates a dose of the aerosolized medicine upon being expelled to ambient pressure, the system comprising:

an endotracheal tube;

a catheter, the catheter having a proximal end and a distal end;

the distal end of the catheter positionable in an air flow passage in the patient'"'"'s respiratory tract, the proximal end adapted to connect to a canister to permit the mixture from the canister to be transmitted into a lumen of the catheter; and

the catheter having a distal orifice communicating with the lumen, the distal orifice oriented to expel the mixture in a reverse direction back towards the proximal end, the catheter located in a lumen of the endotracheal tube.

11. The system of claim 10 in which the catheter is located in a side wall of the endotracheal tube.