Skin vibration method for topical targeted delivery of beneficial agents into hair follicles
First Claim
1. A method to improve delivery of an agent such that the agent is delivered to the hair follicles to hair follicles, said method comprising the steps of administering said agent to an of skin containing hair follicles, and applying vibration of from about 1 Hz to about 100 Hz with an amplitude of about 0.1 mm to about 10 mm in combination with said agent, wherein said agent is applied with an apparatus that comprises(1) a vibration means for applying vibration to the skin with a frequency of from about 1 Hz to about 100 Hz and an amplitude of about 0.1 mm to about 10 mm, and(2) a dispensing means for dispensing and applying said agent to the skin in combination with said vibration.
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Abstract
The present invention provides a methods and apparatuses for use in providing rapid, selective and effective targeted delivery of beneficial substances into hair follicles. The invention relies on the use of vibrational method of delivery of substances of different size from small molecules up to particles compatible with the diameter of hair strand into the hair bulb. The skin is subjected to the vibration of about 1 Hz to about 100 Hz frequency and 0.1 mm to about 10 mm amplitude, an amount which is sufficient to cause mechanical shifts in different directions of skin structure without damage. This results in follicle effective uptake of the tested substances such as carbon particles of different size as well as melanin. The methods and apparatuses of the present invention are particularly useful in conjunction with photosensitive agents and electromagnetic irradiation. Such a combination is used to target the delivery of the agent to within hair follicles and then subsequently activate the agent.
58 Citations
23 Claims
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1. A method to improve delivery of an agent such that the agent is delivered to the hair follicles to hair follicles, said method comprising the steps of administering said agent to an of skin containing hair follicles, and applying vibration of from about 1 Hz to about 100 Hz with an amplitude of about 0.1 mm to about 10 mm in combination with said agent, wherein said agent is applied with an apparatus that comprises
(1) a vibration means for applying vibration to the skin with a frequency of from about 1 Hz to about 100 Hz and an amplitude of about 0.1 mm to about 10 mm, and (2) a dispensing means for dispensing and applying said agent to the skin in combination with said vibration.
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12. A method to improve delivery of an agent to hair follicles, said method comprising the steps of administering said agent to an area of skin containing hair follicles, and applying vibration at about 10 Hz with an amplitude of about 1 mm such that the agent is delivered to the hair follicles, wherein said agent is applied with an apparatus that comprises
(1) a vibration means for applying vibration to the skin with a frequency of about 10 Hz to and an amplitude of about 0.1 mm, and (2) a dispensing means for dispensing and applying said agent to the skin in combination with said vibration.
- 15. An apparatus for selectively delivering an agent to a hair follicle, said apparatuses comprising a vibration means for applying vibration to the skin with a frequency of from about 1 Hz to about 100 Hz and an amplitude of about 0.1 mm to about 10 mm and a dispensing means containing a hair follicle treating agent said agent to the skin in combination with said vibration.
Specification