Methods for reducing the incidence of necrotizing enterocolitis
First Claim
1. A method for reducing the incidence of necrotizing enterocolitis in an infant, said method comprising administering to an infant which is susceptible to necrotizing enterocolitis an effective amount of a nutritional composition containing protein, carbohydrate and phospholipids to provide at least 1.0 mg of ω
- -6 polyunsaturated fatty acids per kg per day.
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Abstract
Enteral formulas that contain long-chain polyunsaturated fatty acids (PUFAs), as arachidonic acid (AA) and docosahexaenoic acid (DHA) that are essentially free of cholesterol, are described. More particularly, the invention relates to methods for reducing the incidence of necrotizing enterocolitis by administering compositions which provide ω-6 and ω-3 long chain PUFAs, phospholipids and/or choline. Compositions from egg yolk lipids are presently preferred as they contain ω-6 and ω-3 long chain PUFAs and are predominantly in a phosphtidylcholine form. This is believed to provide a synergistic effect.
82 Citations
33 Claims
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1. A method for reducing the incidence of necrotizing enterocolitis in an infant, said method comprising administering to an infant which is susceptible to necrotizing enterocolitis an effective amount of a nutritional composition containing protein, carbohydrate and phospholipids to provide at least 1.0 mg of ω
- -6 polyunsaturated fatty acids per kg per day.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for decreasing the incidence of necrotizing enterocolitis in an infant, said method comprising feeding to said infant a sufficient quantity of an enteral nutritional composition containing protein, carbohydrate and phospholipids to provide at least 2.0 mg of ω
- -6 polyunsaturated fatty acids per kg per day.
- View Dependent Claims (15, 16, 17, 18, 19, 20)
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21. A method for decreasing the incidence of necrotizing enterocolitis in an infant, said method comprising administering to an infant susceptible to necrotizing enterocolitis a sufficient quantity of a nutritional composition containing protein, carbohydrates and phospholipids to provide between about 60 and about 2400 μ
- moles of phospholipids per kg day.
- View Dependent Claims (22, 23, 24, 25, 26)
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27. A method for decreasing the incidence of necrotizing enterocolitis in an infant, said method comprising administering to an infant susceptible to necrotizing enterocolitis a sufficient quantity of a nutritional composition containing protein, carbohydrates and phospholipids to provide between about 60 and about 1800 μ
- moles of choline per kg per day.
- View Dependent Claims (28, 29, 30, 31, 32, 33)
Specification