Multi-component material and process for its preparation
First Claim
1. A polymerizable bone cement constituent material stored in dry, stable particulate form which is ready for use by mixing with monomer liquid to induce final polymerization into a bone cement implantation material, the bone cement constituent material comprising:
- a prepolymerization component consisting of particles selected from the group consisting of an acrylate polymer, a methacrylate polymer, a methylmethacrylate polymer, and copolymers thereof, anda filler component consisting of filler particles comprising at least one active substance;
wherein the bone cement constituent material is stored in dry, stable particulate form of particles no greater than 300 μ
m in size and having at least some of the filler particles at least partially embedded into individual particles of the prepolymerization component before the prepolymerization component reacts with the monomer liquid for final polymerization, said prepolymerization component being polymerizable by mixing the bone cement constituent material with monomer liquid into a bone cement implantation material which is biologically inert, said filler particles being accessible in the individual particles of the prepolymerization component for release from the bone cement implantation material by diffusion.
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Abstract
A multiple component material, in particular a filler particle containing implantation material is produced and used to anchor prothesis components in bones, to strengthen bones, as dowel for bone screws and as implants for anchoring screws. The polymer component of the disclosed implantation material is preferably based on an acrylate or polymethacrylate basis, or on an acrylate and methacrylate copolymer or a mixture thereof. The polymer component encloses the filler particles at least in part. Preferably, the filler particles are 5 to 15 μm in size and have at least 50% void volume. The multiple component material is stored in a dry, stable particulate form ready for use by mixing with monomer liquid.
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Citations
20 Claims
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1. A polymerizable bone cement constituent material stored in dry, stable particulate form which is ready for use by mixing with monomer liquid to induce final polymerization into a bone cement implantation material, the bone cement constituent material comprising:
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a prepolymerization component consisting of particles selected from the group consisting of an acrylate polymer, a methacrylate polymer, a methylmethacrylate polymer, and copolymers thereof, and a filler component consisting of filler particles comprising at least one active substance; wherein the bone cement constituent material is stored in dry, stable particulate form of particles no greater than 300 μ
m in size and having at least some of the filler particles at least partially embedded into individual particles of the prepolymerization component before the prepolymerization component reacts with the monomer liquid for final polymerization, said prepolymerization component being polymerizable by mixing the bone cement constituent material with monomer liquid into a bone cement implantation material which is biologically inert, said filler particles being accessible in the individual particles of the prepolymerization component for release from the bone cement implantation material by diffusion. - View Dependent Claims (2, 3, 4, 5, 6, 13)
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7. A polymerizable bone cement constituent material stored in dry, stable powder form which is ready for use by mixing with monomer liquid to induce final polymerization into a bone cement implantation material, the bone cement constituent material comprising:
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a prepolymerization component consisting of particles selected from the group consisting of an acrylate polymer, a methacrylate polymer, a methylmethacrylate polymer, and copolymers thereof; and a filler component consisting of filler particles comprising hydroxylapatite, tricalcium phosphate and/or another calcium phosphate or calcium carbonate compound, an aluminum or an aluminum oxide compound and/or a silicon compound; wherein the bone cement constituent material is stored in dry, stable powder form having individual filler particles only partially embedded into individual polymer and/or copolymer particles before the prepolymerization component reacts with the monomer liquid for final polymerization, said prepolymerization component being polymerizable by mixing the bone cement constituent material with monomer liquid into a bone cement implantation material which is biologically inert, said partially embedded filler particles providing a free surface extending from the individual polymer and/or copolymer particles, said free surface being accessible to bone after final polymerization and upon implantation. - View Dependent Claims (8, 14, 15)
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9. A material in particle form for subsequent use by combining with a liquid monomer to form a bone cement material, the material consisting essentially of:
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50 to 99% by weight of polymer beads based on a plastics material selected from the group consisting of acrylate, methacrylate, methylmethacrylate, epoxy resin and copolymers thereof; and 1 to 50% by weight of irregularly shaped granules comprising polymer particles, the polymer particles based on a plastics material selected from the group consisting of acrylate, methacrylate, methylmethacrylate, epoxy resin and copolymers thereof. - View Dependent Claims (10, 16)
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- 11. A polymerizable bone cement constituent material stored in dry, stable particulate form which is ready for use by mixing with monomer liquid to induce final polymerization into a bone cement implantation material, the bone cement constituent material comprising a prepolymerization component and a filler component, said prepolymerization component consisting of particles selected from the group consisting of an acrylate polymer, a methacrylate polymer, a methylmethacrylate polymer, and copolymers thereof, said filler component consisting of filler particles of a material different from the material of the polymer and/or copolymer particles, wherein the bone cement constituent material is stored in dry, stable particulate form having at least some of the filler particles at least partially embedded into individual polymer and/or copolymer particles before the prepolymerization component is finally polymerized, and wherein the bone cement constituent material is in a crushed form having irregularly shaped granules.
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12. A polymerizable bone cement constituent material stored in dry, stable particulate form which is ready for use by mixing with monomer liquid to induce final polymerization into a bone cement implantation material, the bone cement constituent material comprising:
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a prepolymerization component consisting of particles selected from the group consisting of an acrylate polymer, a methacrylate polymer, a methylmethacrylate polymer, and copolymers thereof, and a filler component consisting of filler particles of a radiographic contrast agent; wherein the bone cement constituent material is stored in dry, stable powder form having individual filler particles at least partially embedded into individual polymer and/or copolymer particles before the prepolymerization component reacts with the monomer liquid for final polymerization, said prepolymerization component being polymerizable by mixing the bone cement constituent material with monomer liquid into a bone cement implantation material which is biologically inert. - View Dependent Claims (19, 20)
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Specification