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Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor

  • US 6,080,860 A
  • Filed: 09/29/1997
  • Issued: 06/27/2000
  • Est. Priority Date: 08/31/1992
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula:

  • ##STR79## wherein Ra is hydrogen, Rb is selected from the group consisting of hydrogen and a 2-cyano-4,5-dialkoxy phenyl group optionally substituted in the 6-position by an alkoxy group, and Rc and Rd are each hydrogen, provided Rc and Rd are not hydrogen when Ra and Rb are hydrogen, or Rc and Rd together with the nitrogen to which they are attached form a 6- or 7-membered closed ring optionally containing a second nitrogen, the closed ring being substituted on the optional second nitrogen by a member selected from the group consisting of unsubstituted or substituted furoyl, benzodioxanyl carbonyl, alkylthiooxadiazole carbonyl, hydroxy alkoxy carbonyl alkenyl and alkyroyl.

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