Atrial defibrillation methods and apparatus

• US 6,081,746 A
• Filed: 08/07/1998
• Issued: 06/27/2000
• Est. Priority Date: 08/07/1998
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories), Duke University
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories), Duke University
• Inventors: Pendekanti, Rajesh, Wolf, Patrick D.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/130,748
• Time in Patent Office: 690 Days
• Field of Search: 607/4, 607/5, 607/14, 607/15
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Methods and apparatus for achieving atrial defibrillation in a heart. Atrial pacing is first conducted from multiple pacing sites in a synchronous manner so as to have the desired effect of maximizing the extent of phase-locked area of atrial tissue. Next, an ADF shock is introduced, if still needed, to achieve atrial defibrillation. ADFT energy requirements have been shown to be dramatically reduced on account of using pacing rates set proportionally to the sensed atrial fibrillation cycle length(s) such that large areas of atrial tissues are phase-locked, and consequently atrial defibrillation can be effected in the patient with greatly reduced energy requirements for ADFTs.

Claims

1. A method of treating a heart in need of atrial defibrillation comprising the steps of:

(a) determining an atrial fibrillation cycle length (AFCL) of a heart suffering from a fibrillating atrium;

(b) sequentially delivering a plurality of synchronous pulses of electrical current to a plurality of different atrial sites at a uniform pulse-to-pulse interval rate selected to be a common percentage value of said AFCL;

(c) determining whether atrial defibrillation is achieved; and

(d) where atrial defibrillation is not determined in step (c), repeating steps (a), (b) and (c) one or more times until atrial defibrillation is achieved.

2. A method of treating a heart in need of atrial defibrillation comprising the steps of:

(a) determining an atrial fibrillation cycle length (AFCL) of a heart suffering from atrial fibrillation;

(b) sequentially delivering a plurality of synchronous pulses of electrical current to a plurality of different atrial pacing sites at a uniform S1--S1 interval rate of approximately 70% to 99% of said AFCL sufficient to induce phase-lock of atrial tissues;

(c) determining whether atrial defibrillation is achieved;

(d) where atrial defibrillation is not determined in step (c), repeating steps (a), (b) and (c) a fixed plural number of times; and

(e) where atrial defibrillation is not achieved upon completing step (d), delivering a defibrillation shock to said heart having phase-lock of atrial tissues at an S1-S2 interval rate of approximately 85% to 95% of said S1--S1 interval rate effective to terminate atrial fibrillation.

3. The method of claim 2, wherein said AFCL is determined in step (a) by sensing a plurality of location-specific atrial fibrillation cycle lengths (AFCLs) at a plurality of different atrial locations, and identifying the minimum atrial fibrillation cycle length from among said individual atrial fibrillation cycle lengths as a basis used for determining the uniform S1--S1 interval.

4. The method of claim 3, wherein said uniform S1--S1 interval is set to be 70% to 99% of said minimum AFCL.

5. The method of claim 3, wherein said uniform S1--S1 interval is set to be 80% to 95% of said minimum AFCL.

6. The method of claim 3, wherein the first pulse of the pulse train is delivered at a time of approximately 70% to 99% of said minimum AFCL after the most recently sensed activation.

7. The method of claim 3, wherein the first pulse of the pulse train is delivered at a time of approximately 80% to 95% of said minimum AFCL after the most recently sensed activation.

8. The method of claim 3, wherein said S1-S2 interval rate is set to be about 90% of said S1--S1 interval.

9. The method of claim 3, wherein said defibrillation shock is less than 1.0 joule.

10. The method of claim 3, wherein said defibrillation shock is less than 0.5 joule.

11. The method of claim 3, wherein each respective AFCL value determined respectively at each said atrial location is determined as a median value of a sequence of individual AFCL values measured at each said atrial location over a given period of time.

12. The method of claim 3, wherein each respective AFCL value determined respectively at each said atrial location is determined as a mean value of a sequence of individual AFCL values measured at each said atrial location over a given period of time.

13. The method of claim 2, wherein said AFCL is determined as a median AFCL value of a sequence of individual AFCL values sensed at the Bachmann'"'"'s Bundle over a given period of time.

14. The method of claim 13, wherein said uniform S1--S1 interval is set to be 80% to 95% of said AFCL.

15. The method of claim 13, wherein the first pulse of the pulse train is delivered at a time of approximately 70% to 99% of said AFCL after the most recently sensed activation.

16. The method of claim 13, wherein said S1-S2 interval rate is set to be about 90% of said S1--S1 interval rate.

17. The method of claim 2, wherein said AFCL is determined as a median AFCL value of a sequence of individual AFCL values sensed at the septum over a given period of time.

18. The method of claim 2, wherein said AFCL is determined as a median AFCL value of a sequence of individual AFCL values sensed at the distal coronary sinus over a given period of time.

19. The method of claim 2, wherein said AFCL is determined as a median AFCL value of a sequence of individual AFCL values sensed at the right atrial free wall over a given period of time.

20. A cardiac therapy apparatus for treating an atrium in need of atrial defibrillation, comprising:

at least one sensor positioned proximate at least one atrial location of said atrium, respectively, for generating respective electrogram signals;

a plurality of pacing electrodes capable of delivering pacing pulses to a plurality of atrial locations, respectively;

a plurality of defibrillation electrodes capable of delivering an ADF shock to said atrium;

signal processing circuitry for receiving said electrograms from said at least one sensor and being capable of detecting an atrial fibrillation episode based on said electrogram signals, and capable of determining an atrial fibrillation cycle length (AFCL) at each of said at least one atrial location based on said electrogram signals, and identifying the minimum AFCL among these where more than one atrial location is sensed, and capable of generating control signals for activating said pacing electrodes such that said pacing electrodes are each capable of (i) delivering pacing pulse trains to said atrium whereby said pacing pulse trains can be synchronously delivered at a uniform S1--S1 interval rate for all pacing sites based as a 70-99% proportion of said minimum AFCL, and (ii) delivering an ADF shock at the end of the last pacing pulse train where said pacing pulse trains alone fail to terminate atrial fibrillation.

21. The cardiac therapy apparatus of claim 20, wherein said signal processing circuitry includes a microprocessor controller, said controller connected electrically to said sensors and said electrodes.

22. The cardiac therapy apparatus of claim 20, wherein said apparatus is an implantable cardioverter-defibrillator device.

23. The cardiac therapy apparatus of claim 20, wherein a plurality of sensors for generating electrograms are positioned proximate said plurality of pacing electrodes at a plurality of respective atrial locations.