Dual-chamber implantable pacemaker having negative AV/PV hysteresis and ectopic discrimination

• US 6,081,747 A
• Filed: 10/26/1998
• Issued: 06/27/2000
• Est. Priority Date: 11/23/1998
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Levine, Paul A., Valikai, Kenneth
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/197,410
• Time in Patent Office: 610 Days
• Field of Search: 607/9, 607/25, 607/14, 607/28, 607/18
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A dual-chamber implantable pacemaker is configured to operate in the DDD or DDDR mode with its AV (or PV) interval automatically set to be a small time interval less than the natural conduction time of a patient. The pacemaker shortens the AV (or PV) interval in response to a verified R-wave occurring within the AV (PV) interval, which it discriminates from an ectopic R-wave by requiring the occurrence of at least three consecutive R-waves or, alternatively, the occurrence of an R-wave having a morphology that matches the morphology of a reference R-wave stored in the pacemaker'"'"'s memory. When the AV (or PV) interval is set to a value that is less than the natural conduction time, preemptive ventricular pacing.

Claims

1. A dual-chamber programmable pacemaker for enhancing cardiac performance of a patient suffering from hypertrophic obstructive cardiomyopathy, comprising:

sensing means for sensing P-waves and R-waves, associated with natural atrial and ventricular contractions, respectively;

means for storing a morphology signal for a naturally-conducted selected reference R-wave resulting from a natural ventricular depolarization;

means for comparing the reference R-wave and a current R-wave and for verifying, based on such comparison, whether the current R-wave has the morphology of a naturally-conducted R-wave or is the result of an ectopic R-wave;

processing means for adjusting an AV/PV interval in accordance with a predetermined strategy when it is verified that a current R-wave has the morphology of a selected reference R-wave and wherein the current R-wave is considered an ectopic R-wave when the current R-wave does not have the morphology of a selected reference R-wave.

2. A dual-chamber programmable pacemaker, as defined in claim 1, wherein the comparing means includes means for calculating a correlation figure based upon the correlation of the stored selected reference R-wave morphology with a current R-wave, and wherein when the correlation figure exceeds a predetermined threshold, the current R-wave is considered a verified R-wave, and wherein when the correlation figure fails to exceed the predetermined threshold, the current R-wave is considered an ectopic R-wave.

3. The dual-chamber programmable pacemaker, as defined in claim 1, further comprising means for resetting the stored selected reference R-wave morphology to a new morphology.

4. The dual-chamber programmable pacemaker, as defined in claim 3, wherein the resetting means comprises means for telemetrically communicating with an external programmer for resetting the stored reference R-wave morphology to the new morphology.

5. The dual-chamber programmable pacemaker, as defined in claim 1, wherein the storing means includes means for storing a plurality of selected R-wave morphologies, and wherein each one of the plurality of such morphologies is selectable based upon a patient'"'"'s physiological condition.

6. The dual-chamber programmable pacemaker, as defined in claim 1, further comprising:

means for determining a natural conduction time interval between an atrial event, either a P-wave or a paced atrial event, and a verified naturally-conducted R-wave; and

wherein the processing means adjusts the AV/PV interval between the atrial event and a paced ventricular contraction to a value that is a prescribed time interval less than the natural conduction time interval.

7. The dual-chamber programmable pacemaker, as defined in claim 6, wherein the processing means, after shortening the AV/PV interval, returns the AV/PV interval to its initial value after a predetermined number of paced ventricular contractions.

8. The dual-chamber programmable pacemaker, as defined in claim 7, wherein the prescribed time interval is 5-100 ms and the predetermined number of paced ventricular contractions is between 4 and 512.

9. A method of operating a dual-chamber programmable pacemaker for enhancing cardiac performance of a patient suffering from hypertrophic obstructive cardiomyopathy, comprising the steps of:

sensing an R-wave;

storing morphology signals for a naturally-conducted selected reference R-wave;

comparing the morphology of a current sensed R-wave with the morphology of a stored reference R-wave to verify that the sensed R-wave has the morphology of a conducted ventricular contraction and is not the result of an ectopic ventricular contraction;

setting an AV/PV interval in accordance with a predetermined strategy when a sensed R-wave is verified as resulting from a conducted ventricular contraction.

10. The method of operating a dual-chamber programmable pacemaker, as defined in claim 9, the comparing step further comprising the step of:

calculating a correlation figure based upon the correlation of the morphology of the stored selected reference R-wave with the morphology of a current R-wave; and

determining if the correlation figure exceeds a predetermined threshold to indicate a verified R-wave, and if the correlation figure fails to exceed the predetermined threshold to indicate that the current R-wave is an ectopic R-wave.

11. The method of operating a dual-chamber programmable pacemaker, as defined in claim 9, further comprising the step of:

storing a plurality of R-wave morphologies; and

selecting the reference R-wave from the plurality of R-wave morphologies stored in the processor.

12. The method of operating a dual-chamber programmable pacemaker, as defined in claim 11, further comprising the steps of:

generating physiological signal representing the patient'"'"'s physiological condition; and

automatically selecting the reference R-wave based on the patient'"'"'s physiological condition.

13. The method of operating a dual-chamber programmable pacemaker, as defined in claim 9, further comprising the step of:

resetting the stored reference R-wave to a new morphology.

14. The method of operating a dual-chamber programmable pacemaker, as defined in claim 9, further comprising the steps of:

measuring the conduction time interval based upon an atrial event and a verified R-wave; and

setting an AV/PV interval between an atrial event and a paced ventricular contraction to a value that is a prescribed time interval less than the measured conduction time interval.

15. The method of operating a dual-chamber programmable pacemaker, as defined in claim 14, further comprising the step of:

decreasing the value of the AV/PV interval by a first predetermined time interval in response to at least three consecutive verified R-waves indicative of natural ventricular contractions.