Device for enhancing transdermal agent flux
First Claim
Patent Images
1. A device for use in introducing or withdrawing an agent through a body surface, comprising:
- a body surface piercing member having a plurality of microprotrusions extending from a body surface proximal portion of the member, the microprotrusions being adapted to pierce the body surface to a depth of up to about 500 μ
m,a housing containing a reservoir for the agent to be introduced or withdrawn, the housing contacting and extending across a substantial portion of a body surface distal portion of the piercing member and maintaining the reservoir in agent-transmitting relation with the pierced body surface, the housing having a compressibility, in a direction normal to the body surface, of less than about 250 μ
m, anda securing member for securing the device to the body surface.
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Accused Products
Abstract
A device (3) comprising a sheet member (6) having a plurality of microprotrusions (4) for penetrating the skin and a substantially incompressible agent reservoir housing (15) contacting and extending across the sheet member (6) for transmitting a hold-down force applied the sheet member (6) to maintain the microprotrusions (4) in skin-piercing relation to the skin, even during and after normal patient body movement.
476 Citations
29 Claims
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1. A device for use in introducing or withdrawing an agent through a body surface, comprising:
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a body surface piercing member having a plurality of microprotrusions extending from a body surface proximal portion of the member, the microprotrusions being adapted to pierce the body surface to a depth of up to about 500 μ
m,a housing containing a reservoir for the agent to be introduced or withdrawn, the housing contacting and extending across a substantial portion of a body surface distal portion of the piercing member and maintaining the reservoir in agent-transmitting relation with the pierced body surface, the housing having a compressibility, in a direction normal to the body surface, of less than about 250 μ
m, anda securing member for securing the device to the body surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification