Methods and devices for the preparation, storage and administration of calcium phosphate cements

• US 6,083,229 A
• Filed: 10/30/1998
• Issued: 07/04/2000
• Est. Priority Date: 12/13/1996
• Status: Expired due to Term

• Current Assignee: Norian Corporation (Johnson & Johnson)
• Original Assignee: Norian Corporation (Johnson & Johnson)
• Inventors: Clawson, Ben, Constantz, Brent R.
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): Woo, Julian W.
• Application Number:
  US09/183,920
• Time in Patent Office: 613 Days
• Field of Search: 606/92, 606/93, 606/94, 604/87, 604/89, 604/416, 604/410, 206/219
• US Class Current: 606/92
• CPC Class Codes: A61B 17/8822 characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum
• CPC Class Codes: A61B 17/8827 with filtering, degassing, venting or pressure relief means
• CPC Class Codes: A61B 17/8833 Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
• CPC Class Codes: A61B 2017/8838 for mixing bone cement or fluid fillers
• CPC Class Codes: A61B 2090/037 with a frangible part, e.g. by reduced diameter
• CPC Class Codes: A61J 1/2027 having frangible parts
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: B01F 31/55 the materials to be mixed being contained in a flexible bag submitted to periodical deformation
• CPC Class Codes: B01F 33/5011 portable during use, e.g. hand-held
• CPC Class Codes: B01F 35/713 comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges containers or packages per se B65D
• CPC Class Codes: B01F 35/7131 Breaking or perforating packages, containers or vials
• CPC Class Codes: B01F 35/7162 A container being placed inside the other before contacting the contents
• CPC Class Codes: B05C 17/00553 with means allowing the stock of material to consist of at least two different components
• CPC Class Codes: B05C 17/01 with manually mechanically or electrically actuated piston or the like B05C17/00533 takes precedence
• CPC Class Codes: B65D 81/3266 separated by a common rupturable seal, a clip or other removable fastening device
• CPC Class Codes: B65D 81/3272 formed by arranging one flexible container within another

Abstract

A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.

Claims

1. A mixing device for mixing a two component cement present in a storage means comprising:

(a) a first compartment comprising said liquid component;

(b) a second compartment having rounded corners and comprising said dry component;

(c) a first frangible barrier separating said first and second compartments;

(d) a third elongate compartment capable of receiving a product produced upon combination of said dry and liquid components; and

(e) a second frangible barrier separating said second and third compartments;

said device comprising;

a positioning means for holding said storage means in position;

a means for moving said liquid component from said first compartment to said second compartment through said frangible seal;

a means for thoroughly combining said liquid component with said dry component in said second compartment to produce a flowable product substantially free of uncombined dry and liquid components; and

a means for moving said flowable product from said second compartment to said third compartment through said second frangible seal.

2. The device according to claim 1, wherein said device further comprises an actuation means.

3. The device according to claim 1, wherein said means for moving said liquid component into said second compartment comprises a planar surface.

4. The device according to claim 1, wherein said means for mixing said dry and liquid components is capable of introducing shear force to the contents of said second compartment.

5. The device according to claim 1, wherein said means for mixing said dry and liquid components comprises at least two grooved rollers.

6. The device according to claim 5, wherein said device further comprises a means for randomizing the movement of said at least two grooved rollers.

7. The device according to claim 1, wherein said means for moving said flowable product from said second to said third compartments comprises a squeegee.

8. The device according to claim 1, wherein said positioning means comprises a substantially planar surface with a depressed region at one end capable of holding at least a portion of said third elongate compartment.

9. A mixing device for mixing a two component cement present in a storage means according to claim 6, said device comprising:

a positioning means for holding said storage means in position;

a means for moving said liquid component from said first compartment to said second compartment through said frangible seal;

a means for thoroughly combining said liquid component with said dry component in said second compartment to produce a flowable product;

a means for moving said flowable product from said second compartment to said third compartment through said second frangible seal; and

an actuation means.

10. The device according to claim 9, wherein said means for moving said liquid component into said second compartment comprises a planar surface.

11. The device according to claim 9, wherein said means for mixing said dry and liquid components is capable of introducing shear force to the contents of said second compartment.

12. The device according to claim 11, wherein said means for mixing said dry and liquid components comprises at least two grooved rollers.

13. The device according to claim 12, wherein said device further comprises a means for randomizing the movement of said at least two grooved rollers.

14. The device according to claim 9, wherein said means for moving said flowable product from said second to said third compartments comprises a squeegee.

15. The device according to claim 9, wherein said means for holding said storage means in position comprises a substantially planar surface with a depressed region at one end capable of holding at least a portion of said third compartment.

16. The device according to claim 9, wherein said actuation means is electronic.

17. The device according to claim 9, wherein said actuation means is pneumatic.

18. The device according to claim 9, wherein said device further comprises a power source.

19. The device according to claim 18, wherein said power source is a battery.