Chemical amplification for the synthesis of patterned arrays
First Claim
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1. An apparatus for solid phase chemical synthesis comprising:
- i) a substrate having one or more synthesis intermediates bound thereon, the one or more synthesis intermediates including a reactive group protected from reaction by a removable protecting group attached by a chemical bond to the one or more synthesis intermediates;
ii) a radiation sensitive compound or group, said radiation sensitive compound or group producing a catalyst when irradiated, andiii) an autocatalytic compound or group, said autocatalytic compound or group generating a protecting group removing product when said autocatalytic compound is activated by said catalyst,wherein the radiation sensitive compound or group and the autocatalytic compound or group are included in a polymer layer on the substrate and further wherein the radiation sensitive compound or group and the autocatalytic compound or group are nonidentical and wherein the catalyst and autocatalytic compound or group are nonidentical.
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Abstract
Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
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Citations
18 Claims
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1. An apparatus for solid phase chemical synthesis comprising:
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i) a substrate having one or more synthesis intermediates bound thereon, the one or more synthesis intermediates including a reactive group protected from reaction by a removable protecting group attached by a chemical bond to the one or more synthesis intermediates; ii) a radiation sensitive compound or group, said radiation sensitive compound or group producing a catalyst when irradiated, and iii) an autocatalytic compound or group, said autocatalytic compound or group generating a protecting group removing product when said autocatalytic compound is activated by said catalyst, wherein the radiation sensitive compound or group and the autocatalytic compound or group are included in a polymer layer on the substrate and further wherein the radiation sensitive compound or group and the autocatalytic compound or group are nonidentical and wherein the catalyst and autocatalytic compound or group are nonidentical. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A substrate for use in making a polymer array comprising:
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a) a substrate having one or more synthesis intermediates bound thereon, the one or more synthesis intermediates having a reactive group protected from reaction by a protective group attached by a chemical bond to the one or more synthesis intermediates; b) a catalyst system for catalyzing removal of the protective group, the catalyst system contacting the synthesis intermediates and wherein the catalyst system is included in a polymer layer on the substrate and further wherein the catalyst system and the protective group are nonidentical.
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18. A method of making a substrate for use in making a polymer array comprising:
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a) providing a substrate surface having one or more synthesis intermediates bound thereon, the one or more synthesis intermediates having a reactive group protected from reaction by a protective group attached by a chemical bond to the one or more synthesis intermediates; b) applying over the substrate surface a polymer layer having a catalyst system capable of catalyzing removal of the protective group.
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Specification