Electrochemical analyte measurement system
First Claim
1. An analyte measurement system, comprising:
- a fiber configured and arranged for subcutaneous implantation of a portion of the fiber in a person and for acquisition of an analyte-containing sample of fluid from the person;
an electrochemical sensor configured and arranged for disposition in fluid communication with the fiber to receive the analyte-containing sample of fluid directly from the person, the electrochemical sensor comprisinga non-corroding working electrode, anda sensing layer disposed on the non-corroding working electrode, the sensing layer comprising a non-leachable, analyte-responsive enzyme.
7 Assignments
0 Petitions
Accused Products
Abstract
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
-
Citations
44 Claims
-
1. An analyte measurement system, comprising:
-
a fiber configured and arranged for subcutaneous implantation of a portion of the fiber in a person and for acquisition of an analyte-containing sample of fluid from the person; an electrochemical sensor configured and arranged for disposition in fluid communication with the fiber to receive the analyte-containing sample of fluid directly from the person, the electrochemical sensor comprising a non-corroding working electrode, and a sensing layer disposed on the non-corroding working electrode, the sensing layer comprising a non-leachable, analyte-responsive enzyme. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. A method of measuring a concentration of an analyte in a sample, the method comprising steps of:
-
implanting a portion of a fiber into subcutaneous tissue of a person; transporting an analyte-containing fluid directly from the person to an electrochemical sensor in fluid communication with the fiber; generating an electrical signal in the electrochemical sensor, wherein the electrochemical sensor comprises a working electrode and a sensing layer disposed over the working electrode, the sensing layer comprising a non-leachable, analyte-responsive enzyme; and determining, from the electrical signal, a concentration of the analyte in the analyte-containing fluid. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
-
Specification