Atrial defibrillation methods and apparatus

• US 6,085,116 A
• Filed: 08/07/1998
• Issued: 07/04/2000
• Est. Priority Date: 08/07/1998
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated), Duke University
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated), Duke University
• Inventors: Pendekanti, Rajesh, Wolf, Patrick D.
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/130,990
• Time in Patent Office: 697 Days
• Field of Search: 607/4, 607/5, 607/14
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Methods and apparatus for achieving atrial defibrillation in a heart. Atrial pacing is first conducted from a single pacing site so as to have the desired effect of maximizing the extent of phase-locked area of atrial tissue. Next, an ADF shock is introduced, if still needed, to achieve atrial defibrillation. ADFT energy requirements have been shown to be dramatically reduced on account of using a pacing rate set proportionally to the atrial fibrillation cycle length such that large areas of atrial tissues are phase-locked, and consequently atrial defibrillation can be effected in the patient with greatly reduced energy requirements for ADFTs.

Claims

1. A method of treating a heart in need of atrial defibrillation comprising the steps of:

(a) determining an atrial fibrillation cycle length (AFCL) of a heart suffering from a fibrillating atrium; and

(b) positioning a plurality of defibrillation electrodes in said atrium;

(c) sequentially delivering a plurality of pulses of electrical current to a single atrial site being a low potential gradient region of atrial tissue at a constant pulse-to-pulse interval rate selected to be a percentage value of said AFCL effective to defibrillate said atrium;

(d) determining whether atrial defibrillation is achieved; and

(e) where atrial defibrillation is not determined in step (d), repeating steps (a), (b) and (c) one or more times until atrial defibrillation is achieved.

2. A method of treating a heart in need of atrial defibrillation comprising the steps of:

(a) determining an atrial fibrillation cycle length (AFCL) of a heart suffering from atrial fibrillation;

(b) positioning a plurality of defibrillation electrodes in said atrium;

(c) sequentially delivering a plurality of pulses of electrical current to a single atrial pacing site being a low potential gradient region of atrial tissue at a constant S1-S1 interval rate of approximately 70% to 99% of said AFCL sufficient to induce phase-lock of atrial tissues;

(d) determining whether atrial defibrillation is achieved;

(e) where atrial defibrillation is not determined in step (d), repeating steps (a), (b) and (c) a fixed plural number of times; and

(f) where atrial defibrillation is not determined upon completing step (e), delivering a defibrillation shock to said heart having phase-lock of atrial tissues at an S1-S2 interval rate of approximately 85% to 95% of said S1-S1 interval rate effective to terminate atrial fibrillation.

3. The method of claim 2, wherein said uniform S1-S1 interval is set to be 80% to 95% of said AFCL.

4. The method of claim 2, wherein the first pulse of the pulse train is delivered at a time of approximately 70% to 99% of said AFCL after the most recently sensed activation.

5. The method of claim 2, wherein the first pulse of the pulse train is delivered at a time of approximately 80% to 95% of said AFCL after the most recently sensed activation.

6. The method of claim 2, wherein said S1-S2 interval rate is set to be about 90% of said S1-S1 interval.

7. The method of claim 2, wherein said defibrillation shock is less than 1.0 joule.

8. The method of claim 2, wherein said defibrillation shock is less than 0.5 joules.

9. A cardiac therapy apparatus for treating an atrium in need of atrial defibrillation, comprising:

a sensor positioned proximate an atrial location of said atrium for generating electrogram signals;

a plurality of defibrillation electrodes capable of delivering an ADF shock to said atrium;

a single pacing electrode positioned adjacent a low potential gradient region of said atrium capable of delivering pacing pulses to said atrial low potential gradient region;

signal processing circuitry for receiving said electrogram signals from said sensor and being capable of detecting an atrial fibrillation episode based on said electrogram signals, determining an atrial fibrillation cycle length (AFCL) at said atrial location based on said electrogram signals, and generating control signals for activating said electrode such that said electrode is capable of (i) delivering pacing pulse trains to said atrium whereby the first pulse delivered of said pulse train is delivered at a time of approximately 70% to 99% of said AFCL after the most recently sensed activation and said pacing pulse trains can be thereafter delivered at an S1-S1 interval rate for said pacing site based as a 70-99% proportion of said AFCL and (ii) delivering an ADF shock at the end of the last pacing pulse train where a determination has been made that pacing pulse trains alone fail to terminate atrial fibrillation.

10. The cardiac therapy apparatus of claim 9, wherein said signal processing circuitry includes a microprocessor controller, said controller connected electrically to said sensors and said electrodes.

11. The cardiac therapy apparatus of claim 9, wherein said apparatus is an implantable cardioverter-defibrillator device.