Intrapulmonary delivery device

• US 6,085,742 A
• Filed: 04/17/1998
• Issued: 07/11/2000
• Est. Priority Date: 04/02/1997
• Status: Expired due to Term

• Current Assignee: Aeromax Technologies Inc.
• Original Assignee: Aeromax Technologies Inc.
• Inventors: Lindsay, Stuart, Wachter, Allan
• Primary Examiner(s): Lewis, Aaron J.
• Assistant Examiner(s): MITCHELL, TEENA KAY
• Application Number:
  US09/062,033
• Time in Patent Office: 816 Days
• Field of Search: 128/200.14, 128/200.21, 128/203.12, 128/200.23, 128/204.23, 128/204.26
• US Class Current: 128/200.23
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/0088 with variable volume
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2206/10 Flow characteristics

Abstract

The invention provides an inhalation device for administering a medicament within a prescribed dosage range to avoid over or under administration. The device contains in the mouthpiece or nozzle a channel which follows the Poiseuille equation and provides a flow rate of the fluid containing the medicament at a flow rate of between 0.5 and 3.0 l/s.

Claims

1. A delivery device for administering metered doses of medicament from a medicament container for inhalation by a patient comprising:

a mouthpiece having a mouthpiece passage extending therethrough through which medicament can pass, said mouthpiece passage having a first cross sectional size;

a medicament receiving chamber into which medicament from said medicament container is dispensed,

a medicament container holder for a medicament container mounted on said medicament receiving chamber, said medicament container holder having an actuator for supplying medicament from a medicament container mounted in said medicament container holder to said medicament receiving chamber; and

an elongate, restricted tubular delivery channel connecting the mouthpiece passage with the medicament receiving chamber, said elongate, restricted delivery channel being formed with a length and a second cross sectional size smaller than said first cross sectional size of the mouthpiece passage to restrict and control the flow rate of medicament from the medicament receiving chamber to the mouthpiece passage by requiring the formation of a pressure differential to achieve a flow rate of medicament from the medicament receiving chamber through the elongate restricted delivery channel to the mouthpiece passage.

2. The delivery device of claim 1 wherein said elongate restricted tubular delivery channel is a straight channel which forms a Poiseuille gauge which delivers a flow rate within a range of from 0.5 to 3.0 l/s.

3. The delivery device of claim 1 wherein an enclosed chamber extends between said mouthpiece and said medicament receiving chamber, said enclosed chamber having a first endwall and a second endwall spaced from said first endwall, said mouthpiece extending outwardly from the first endwall with the first endwall extending over said mouthpiece passage, said elongated restricted tubular delivery channel extending through said enclosed chamber and opening at a first end through said first endwall into said mouthpiece passage and opening at a second end through said second endwall into said medicament receiving chamber.

4. The delivery device of claim 3 wherein said elongated restricted tubular delivery channel is a straight channel which forms a Poiseuille gauge.

5. The delivery device of claim 3 wherein said medicament receiving chamber is expandible and collapsible.

6. The delivery device of claim 5 wherein said medicament receiving chamber collapses over said enclosed chamber.

7. The delivery device of claim 1 wherein said elongate restricted tubular delivery channel provides a pressure drop described by the equation:

##EQU3## wherein v/t=F, the flow rate (in m³ per second), μ

is the viscosity of a containing propellant (1.8×

10^-5 m^-1 s^-1), l the length of the restricted delivery channel and a is the radius of the restricted delivery channel.

8. The delivery device of claim 7 wherein an enclosed chamber extends between said mouthpiece and said medicament receiving chamber, said enclosed chamber having a first endwall and a second endwall spaced from said first endwall, said mouthpiece extending outwardly from the first endwall with the first endwall extending over said mouthpiece passage, said elongated restricted tubular delivery channel extending through said enclosed chamber and opening at a first end through said first endwall into said mouthpiece passage and opening at a second end through said second endwall into said medicament receiving chamber.

9. The delivery device of claim 8 wherein said elongate restricted tubular delivery channel is a straight channel which forms a Poiseuille gage which delivers a flow rate within a range of from 0.5 to 3.0 l/s.

10. A delivery device for administering metered doses of propellant driven medicament for inhalation by a patient comprising:

a medicament receiving chamber for receiving metered doses of propellant driven medicament, said medicament receiving chamber being expansible and contractible,

a mouthpiece with a mouthpiece channel for passing medicament to a patient,

and an elongate delivery tube having a central conduit connecting said mouthpiece channel with said medicament receiving chamber said elongate delivery tube being formed to restrict the flow rate of medicament from the medicament receiving chamber to the mouthpiece and to provide a pressure drop described by the equation;

##EQU4## wherein v/t=F, the flow rate (in m³ per second), μ

is the viscosity of a containing propellant (1.8×

10^-5 m^-1 s^-1), l the length of the central conduit and a is the radius of the central conduit.

11. A delivery device for administering metered doses of medicament from a medicament container for inhalation by a patient comprising:

a mouthpiece;

a medicament receiving chamber into which medicament from said medicament container is dispensed,

an enclosed chamber extending between said mouthpiece and said medicament receiving chamber, said mouthpiece being mounted on said enclosed chamber, and

a straight, elongate, restricted, tubular delivery channel received within said mouthpiece and extending from within said mouthpiece through said enclosed chamber to said medicament receiving chamber to provide medicament from said medicament receiving chamber to said mouthpiece, said straight, elongate, restricted tubular delivery channel being formed to restrict and control the flow rate of medicament from the medicament receiving chamber through the mouthpiece by requiring the formation of a pressure differential to achieve such flow rate, the straight, elongate, restricted, tubular delivery channel forming a Poiseuille gauge which delivers a flow rate of from 0.5 to 3.0 l/s.