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Pharmaceutical compositions containing interdigitation-fusion liposomes and gels

  • US 6,086,851 A
  • Filed: 06/24/1997
  • Issued: 07/11/2000
  • Est. Priority Date: 01/12/1990
  • Status: Expired due to Term
First Claim
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1. An interdigitation-fusion liposome prepared by a method which comprises the steps of:

  • (a) preparing sized liposomes having an average diameter of less than about 0.40 microns and comprising a symmetrical saturated phospholipid;

    (b) combining the sized liposomes with an amount of an inducer effective to induce fusion of the sized liposomes and interdigitation of the saturated phospholipid at a temperature and for a period of time effective to induce fusion of the sized liposomes and interdigitation of the saturated phospholipid, so as to form an interdigitation-fusion gel from the sized liposomes; and

    ,(c) incubating the interdigitation-fusion gel at a temperature above the transition temperature of the saturated phospholipid in the gel for a period of time effective to form an interdigitation-fusion liposome from the gel.

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