Pharmaceutical compositions containing interdigitation-fusion liposomes and gels
First Claim
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1. An interdigitation-fusion liposome prepared by a method which comprises the steps of:
- (a) preparing sized liposomes having an average diameter of less than about 0.40 microns and comprising a symmetrical saturated phospholipid;
(b) combining the sized liposomes with an amount of an inducer effective to induce fusion of the sized liposomes and interdigitation of the saturated phospholipid at a temperature and for a period of time effective to induce fusion of the sized liposomes and interdigitation of the saturated phospholipid, so as to form an interdigitation-fusion gel from the sized liposomes; and
,(c) incubating the interdigitation-fusion gel at a temperature above the transition temperature of the saturated phospholipid in the gel for a period of time effective to form an interdigitation-fusion liposome from the gel.
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Abstract
This invention provides a composition containing a sized liposome comprising a lipid and an inducer; the sized liposome has a diameter of at most about 1 micron and the inducer is present in an amount effective to induce interdigitation-fusion of the sized liposome. Also provided herein are interdigitation-fusion liposomes and gels, and methods of making the same.
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Citations
14 Claims
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1. An interdigitation-fusion liposome prepared by a method which comprises the steps of:
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(a) preparing sized liposomes having an average diameter of less than about 0.40 microns and comprising a symmetrical saturated phospholipid; (b) combining the sized liposomes with an amount of an inducer effective to induce fusion of the sized liposomes and interdigitation of the saturated phospholipid at a temperature and for a period of time effective to induce fusion of the sized liposomes and interdigitation of the saturated phospholipid, so as to form an interdigitation-fusion gel from the sized liposomes; and
,(c) incubating the interdigitation-fusion gel at a temperature above the transition temperature of the saturated phospholipid in the gel for a period of time effective to form an interdigitation-fusion liposome from the gel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification