Surfactant-based antimicrobial compositions and methods for using same

• US 6,087,400 A
• Filed: 06/11/1999
• Issued: 07/11/2000
• Est. Priority Date: 11/18/1997
• Status: Expired due to Term

• Current Assignee: Pacific World Corporation (PWC Holding Corp.)
• Original Assignee: Woodward Laboratories, Inc.
• Inventors: Gerenraich, Kenneth B., Dyer, David L.
• Primary Examiner(s): KRASS, FREDERICK F
• Application Number:
  US09/330,872
• Time in Patent Office: 396 Days
• Field of Search: 514/643, 514/975
• US Class Current: 514/643
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A61K 2800/596 Mixtures of surface active compounds
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/442 substituted by amido group(s)
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations

Abstract

Antimicrobial compositions and methods for preparing and using same are provided. The antimicrobial compositions are surfactant-based and contain certain benzalkonium chloride homologs. The compositions are useful in treating infections in animals and humans, and can be applied to areas including the skin, nails, and mouth.

Claims

1. An antimicrobial, pharmaceutical composition for topical or oral administration, comprising:

a. from about 0.05 to about 5 percent by weight benzalkonium chloride, wherein greater than 90 percent by weight of the benzalkonium chloride is selected from the group consisting of of benzalkonium chloride homologs having the formula;

##STR4## wherein R represents an alkyl side chain of from 12 to 14 carbon atoms;

b. from 0.1-20 weight percent of a surfactant system comprising at least one nonionic surfactant comprising alkanolamine, alkyldimethyl oxide, coconut monoethanolamine, cetyldimethylamine oxide, stearamine oxide, oleamine oxide, or cocamidopropylamine dimethyl oxide; and

c. at least about 60 weight percent water.

2. The antimicrobial composition of claim 1 wherein the surfactant system comprises from about 0.05 to about 8 weight percent of the nonionic surfactant.

3. The antimicrobial composition of claim 1 wherein the surfactant system comprises at least one amphoteric surfactant.

4. The antimicrobial composition of claim 3 wherein the surfactant system further comprises at least one amphoteric surfactant comprising cocamido betaine, oleyl betaine, cocamphdiacetate, cocamidopropylhydroxysultaine, or cocamidopropyldimethyl betaine.

5. The antimicrobial composition of claim 1 wherein the surfactant system further comprises at least one cationic surfactant.

6. The antimicrobial composition of claim 5 wherein the surfactant system further comprises at least one cationic surfactant comprising cetyl trimethyl ammonium chloride, trimethyl coco quaternary ammonium chloride, diquaternary polydimethylsiloxane, or trimethyl quaternary ammonium chloride.

7. The antimicrobial composition of claim 1 wherein at least 98 percent by weight of the benzalkonium chloride is selected from the group of benzalkonium chloride homologs having the formula:

##STR5## wherein R represents an alkyl side chain of from 12 to 14 carbon atoms.

8. An antimicrobial, pharmaceutical composition for topical or oral administration, comprising:

a. from about 0.05 to about 5 percent by weight benzalkonium chloride, wherein greater than 90 percent by weight of the benzalkonium chloride is selected from the group consisting of of benzalkonium chloride homologs having the formula;

##STR6## wherein R represents an alkyl side chain of from 12 to 14 carbon atoms;

b. from 0.1-20 weight percent of a surfactant system comprising at least one amphoteric surfactant comprising of cocamido betaine, oleyl betaine, cocamphdiacetate, cocamidopropylhydroxysultaine, or cocamidopropyldimethyl betaine; and

c. at least about 60 weight percent water.

9. The antimicrobial composition of claim 8 wherein the surfactant system comprises from about 0.05 to about 8 weight percent of the amphoteric surfactant.

10. The antimicrobial composition of claim 8 wherein the surfactant system further comprises at least one nonionic surfactant.

11. The antimicrobial composition of claim 8 wherein the surfactant system further comprises at least one nonionic surfactant comprising of alkanolamine, alkyldimethyl oxide, coconut monoethanolamine, cetyldimethylamine oxide, stearamine oxide, oleamine oxide, or cocamidopropylamine dimethyl oxide.

12. The antimicrobial composition of claim 8 wherein the surfactant system further comprises at least one cationic surfactant.

13. The antimicrobial composition of claim 8 wherein the surfactant system further comprises at least one cationic surfactant comprising cetyl trimethyl ammonium chloride, trimethyl coco quaternary ammonium chloride, diquaternary polydimethylsiloxane, or trimethyl quaternary ammonium chloride.

14. The antimicrobial composition of claim 8 wherein at least 98 percent by weight of the benzalkonium chloride is selected from the group consisting of of benzalkonium chloride homologs having the formula:

##STR7## wherein R represents an alkyl side chain of from 12 to 14 carbon atoms.

15. An antimicrobial, pharmaceutical composition for topical or oral administration, comprising:

a. from about 0.05 to about 5 percent by weight benzalkonium chloride, wherein greater than 90 percent by weight of the benzalkonium chloride is selected from the group consisting of of benzalkonium chloride homologs having the formula;

##STR8## wherein R represents an alkyl side chain of from 12 to 14 carbon atoms;

b. from 0.1-20 weight percent of a surfactant system comprising at least one cationic surfactant comprising cetyl trimethyl ammonium chloride, trimethyl coco quaternary ammonium chloride, diquaternary polydimethylsiloxane, or trimethyl quaternary ammonium chloride; and

c. at least about 60 weight percent water.

16. The antimicrobial composition of claim 15 wherein the surfactant system comprises from about 0.05 to about 5 weight percent of the cationic surfactant.

17. The antimicrobial composition of claim 15 wherein the surfactant system further comprises at least one amphoteric surfactant.

18. The antimicrobial composition of claim 15 wherein the surfactant system further comprises at least one amphoteric surfactant comprising cocamido betaine, oleyl betaine, cocamphdiacetate, cocamidopropylhydroxysultaine, or cocamidopropyldimethyl betaine.

19. The antimicrobial composition of claim 15 wherein the surfactant system further comprises at least one nonionic surfactant.

20. The antimicrobial composition of claim 15 wherein the surfactant system further comprises at least one nonionic surfactant comprising alkanolamine, alkyldimethyl oxide, coconut monoethanolamine, cetyldimethylamine oxide, stearamine oxide, oleamine oxide, or cocamidopropylamine dimethyl oxide.

21. The antimicrobial composition of claim 15 wherein at least 98 percent by weight of the benzalkonium chloride is selected from the group of benzalkonium chloride homologs having the formula:

##STR9## wherein R represents an alkyl side chain of from 12 to 14 carbon atoms.

22. An antimicrobial, pharmaceutical composition for topical or oral administration, comprising:

a. from about 0.05 to about 5 percent by weight benzalkonium chloride, wherein greater than 90 percent by weight of the benzalkonium chloride is selected from the group consisting of of benzalkonium chloride homologs having the formula;

##STR10## wherein R represents an alkyl side chain of from 12 to 14 carbon atoms;

b. from 0.1-20 weight percent of a surfactant system comprising;

i. at least one amphoteric surfactant comprising cocamido betaine, oleyl betaine, cocamphdiacetate, cocamidopropylhydroxysultaine, or cocamidopropyldimethyl betaine;

ii. at least one nonionic surfactant comprising alkanolamine, alkyldimethyl oxide, coconut monoethanolamine, cetyldimethylamine oxide, stearamine oxide, oleamine oxide, or cocamidopropylamine dimethyl oxide; and

iii. at least one cationic surfactant comprising cetyl trimethyl ammonium chloride, trimethyl coco quaternary ammonium chloride, diquaternary polydimethylsiloxane, or trimethyl quaternary ammonium chloride; and

c. at least about 60 weight percent water.