Method of flow measurements
First Claim
1. A method of measuring flow of a fluid flowing in a narrow channel, comprising the steps of:
- providing a sensor having a first sensitive element sensitive to pressure, and a second sensitive element sensitive to a selected chemical or physical property, both arranged at a distal end of a guide wire, for registering pressure values and values of said selected chemical or physical property;
locating said sensor at a point of measurement in said narrow channel;
injecting, into said flowing fluid, a bolus of liquid having a property distinguishable from the selected property of said flowing fluid and detectable by said second sensitive element;
registering with said first sensitive element a pressure pulse resulting from said injecting step, and taking a point in time of said pulse as a starting point for measuring elapsed time;
registering with said second sensitive element said distinguishable property of said bolus in said fluid when at least a portion of said bolus in said fluid having said distinguishable property passes said second sensitive element;
registering the elapsed time from said injecting of said bolus of liquid having said distinguishable property, up to said registering of said distinguishable property; and
calculating a flow parameter on the basis of a value of said registered pressure pulse and a value of said distinguishable property.
3 Assignments
0 Petitions
Accused Products
Abstract
A system and method for measuring flow of a fluid flowing in a narrow channel. A sensor is provided, having an element sensitive to pressure, and an element sensitive to a selected chemical or physical property, both arranged at the distal end of a guide wire, for registering pressure values and values of said selected chemical or physical property. The sensor is located at a point of measurement in the narrow channel. A bolus of liquid having a property distinguishable from the selected property of the flowing fluid and detectable by the second sensitive element is injected into the fluid, and registered with said first sensitive element is a pressure pulse resulting from said injecting step. A point in time of the pulse is taken as a starting point for measuring elapsed time. Registered with the second sensitive element is the distinguishable property of the bolus in the fluid when the bolus in the fluid passes the second sensitive element. The elapsed time from the injecting of the bolus, up to the registering of the distinguishable property is noted, and a flow parameter is calculated on the basis of a value of the registered pressure pulse and a value of the distinguishable property.
72 Citations
22 Claims
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1. A method of measuring flow of a fluid flowing in a narrow channel, comprising the steps of:
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providing a sensor having a first sensitive element sensitive to pressure, and a second sensitive element sensitive to a selected chemical or physical property, both arranged at a distal end of a guide wire, for registering pressure values and values of said selected chemical or physical property; locating said sensor at a point of measurement in said narrow channel; injecting, into said flowing fluid, a bolus of liquid having a property distinguishable from the selected property of said flowing fluid and detectable by said second sensitive element; registering with said first sensitive element a pressure pulse resulting from said injecting step, and taking a point in time of said pulse as a starting point for measuring elapsed time; registering with said second sensitive element said distinguishable property of said bolus in said fluid when at least a portion of said bolus in said fluid having said distinguishable property passes said second sensitive element; registering the elapsed time from said injecting of said bolus of liquid having said distinguishable property, up to said registering of said distinguishable property; and calculating a flow parameter on the basis of a value of said registered pressure pulse and a value of said distinguishable property.
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2. A method of measuring flow of a fluid flowing in a blood vessel, comprising the steps of:
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providing a sensor having a pressure sensitive element and a temperature sensitive element, both arranged at a distal end of a guide wire, for registering pressure values and temperature values; locating said sensor at a point of measurement in said blood vessel; injecting, into said flowing fluid, a bolus of liquid of a temperature that differs from the temperature of said flowing fluid at a point upstream of said point of measurement; registering with said pressure sensitive element a pressure pulse resulting from said injecting step, and taking a point in time of said pulse as a starting point for measuring elapsed time; registering with said temperature sensitive element a temperature change in said fluid caused by said bolus in said fluid having a different temperature, when said fluid having a different temperature passes said temperature sensitive element; registering the elapsed time from said injecting of said bolus of liquid having a different temperature, up to said registering of said temperature change; calculating a flow parameter on the basis of said registered pressure pulse value and registered temperature value. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A system for measuring a flow parameter of a fluid flowing in narrow channels, comprising:
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a guide wire having a distal end, and being provided with sensor means for selectively detecting pressure and another physical or chemical property of the flowing fluid, and for outputting signals representative of said pressure and other physical or chemical property; a control unit coupled to said sensor means; means for injecting, into said flowing fluid, a bolus amount of liquid having physical or chemical property distinguishable from a property of said flowing fluid, for creating a pressure pulse; timer means in said control unit which, is coupled so as to start to measure time in response to said pressure pulse detected by said sensor means; processing means in said control unit for processing said measured time, and said signals representative of said other physical or chemical property; and means in said control unit for calculating a flow parameter on the basis of said processed signals. - View Dependent Claims (19, 20, 21)
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22. A method of diagnosing small vessel disease, by performing measurements of flowing fluid at a site in a blood vessel distally of a suspected stricture, comprising the steps of:
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a) providing a sensor having a pressure sensitive element and a temperature sensitive element both arranged at a distal end of a guide wire for registering pressure and temperature values; b) locating said sensor at a point of measurement in said blood vessel; c) injecting a bolus of liquid of a temperature that differs from the temperature of said flowing fluid at a point upstream of said point of measurement; d) registering the pressure pulse resulting from said injecting step by said pressure sensitive element, and taking the point in time of said pulse as a starting point for measuring elapsed time; e) registering a temperature change of said fluid caused by said injecting step when said fluid passes said temperature sensitive element; f) registering the elapsed time from said injection of said bolus of liquid to said registering of said temperature change; g) calculating a flow parameter Trest on the basis of said registered pressure and temperature values, corresponding to a rest situation; h) injecting a vaso dilating drug in said vessel to simulate a work condition; i) repeating the steps a) to f); j) calculating a flow parameter Twork on the basis of said registered pressure and temperature values, corresponding to a work situation; k) calculating Coronary Fractional Reserve=Trest /Twork ; and l) comparing the calculated Coronary Fractional Reserve with a corresponding quantity representative of a healthy patient.
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Specification